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J. Fungi 2018, 4(4), 130; https://doi.org/10.3390/jof4040130

Chemical Diversity and Biological Activities of Phaeosphaeria Fungi Genus: A Systematic Review

1
Sorbonne Universités, Muséum National d’Histoire Naturelle, Molécules de Communication et Adaptation des Micro-organismes, UMR 7245 CNRS/MNHN, 75005 Paris, France
2
Chemistry Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt
Received: 17 November 2018 / Revised: 3 December 2018 / Accepted: 4 December 2018 / Published: 5 December 2018
(This article belongs to the Special Issue Fungal Polyketides and Other Secondary Metabolites)
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Abstract

Microbial natural products (MNPs) have been identified as important hotspots and effective sources for drug lead discovery. The genus Phaeosphaeria (family: Phaeosphaeriaceae, order: Pleosporales), in particular, has produced divergent chemical structures, including pyrazine alkaloids, isocoumarins, perylenequinones, anthraquinones, diterpenes, and cyclic peptides, which display a wide scope of biological potentialities. This contribution comprehensively highlights, over the period 1974–2018, the chemistry and biology of the isolated natural products from the micro-filamentous Phaeosphaeria fungi genus. A list of 71 compounds, with structural and biological diversities, were gathered into 5 main groups. View Full-Text
Keywords: Phaeosphaeria; pyrazine alkaloids; polyketides; isocoumarins; perylenequinones; anthraquinones; cyclic peptides; bioactivities Phaeosphaeria; pyrazine alkaloids; polyketides; isocoumarins; perylenequinones; anthraquinones; cyclic peptides; bioactivities
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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El-Demerdash, A. Chemical Diversity and Biological Activities of Phaeosphaeria Fungi Genus: A Systematic Review. J. Fungi 2018, 4, 130.

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