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J. Fungi 2018, 4(3), 101; https://doi.org/10.3390/jof4030101

Mangrove-Associated Fungi: A Novel Source of Potential Anticancer Compounds

1
TERI-Deakin Nano Biotechnology Centre, The Energy and Resources Institute (TERI), Darbari Seth Block, IHC Complex, Lodhi Road, New Delhi 110003, India
2
Department of Biotechnology, Motilal Nehru National Institute of Technology, Allahabad 211004, India
3
Department of Biotechnology, Thapar Institute of Engineering & Technology, Patiala, Punjab 147004, India
*
Author to whom correspondence should be addressed.
Received: 16 July 2018 / Revised: 14 August 2018 / Accepted: 21 August 2018 / Published: 24 August 2018
(This article belongs to the Special Issue Fungal Endophytes in Plants)
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Abstract

Cancer is the second leading cause of death worldwide, and the number of cases is increasing alarmingly every year. Current research focuses on the development of novel chemotherapeutic drugs derived from natural as well as synthetic sources. The abundance and diversity in natural resources offer tremendous potential for the discovery of novel molecules with unique mechanisms for cancer therapy. Mangrove-derived fungi are rich source of novel metabolites, comprising novel structure classes with diverse biological activities. Across the globe, coastal areas are primarily dominated by mangrove forests, which offer an intensely complex environment and species that mostly remain unexplored. In recent years, many structurally diverse compounds with unique skeletons have been identified from mangrove fungi and evaluated for their antiproliferative properties. These compounds may serve as lead molecules for the development of new anticancer drugs. Mangrove endophytes can be modulated using epigenetic means or culture optimization methods to improve the yield or to produce various similar analogs. The present review provides an insight into the bioactive metabolites from mangrove endophytes reported during the period from 2012 to 2018 (up to April, 2018) along with their cytotoxic properties, focusing on their chemical structures and mode of action, as indicated in the literature. View Full-Text
Keywords: endophytic fungi; anticancer compounds; mangroves; co-culture; epigenetic modification endophytic fungi; anticancer compounds; mangroves; co-culture; epigenetic modification
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Deshmukh, S.K.; Gupta, M.K.; Prakash, V.; Reddy, M.S. Mangrove-Associated Fungi: A Novel Source of Potential Anticancer Compounds. J. Fungi 2018, 4, 101.

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