Next Article in Journal / Special Issue
A Solvent-Free Approach for Converting Cellulose Waste into Volatile Organic Compounds with Endophytic Fungi
Previous Article in Journal
Immunity and Treatment of Sporotrichosis
Previous Article in Special Issue
Endophytic Fungi: A Source of Potential Antifungal Compounds
Article Menu
Issue 3 (September) cover image

Export Article

Open AccessReview
J. Fungi 2018, 4(3), 101;

Mangrove-Associated Fungi: A Novel Source of Potential Anticancer Compounds

TERI-Deakin Nano Biotechnology Centre, The Energy and Resources Institute (TERI), Darbari Seth Block, IHC Complex, Lodhi Road, New Delhi 110003, India
Department of Biotechnology, Motilal Nehru National Institute of Technology, Allahabad 211004, India
Department of Biotechnology, Thapar Institute of Engineering & Technology, Patiala, Punjab 147004, India
Author to whom correspondence should be addressed.
Received: 16 July 2018 / Revised: 14 August 2018 / Accepted: 21 August 2018 / Published: 24 August 2018
(This article belongs to the Special Issue Fungal Endophytes in Plants)
Full-Text   |   PDF [2194 KB, uploaded 27 August 2018]   |  


Cancer is the second leading cause of death worldwide, and the number of cases is increasing alarmingly every year. Current research focuses on the development of novel chemotherapeutic drugs derived from natural as well as synthetic sources. The abundance and diversity in natural resources offer tremendous potential for the discovery of novel molecules with unique mechanisms for cancer therapy. Mangrove-derived fungi are rich source of novel metabolites, comprising novel structure classes with diverse biological activities. Across the globe, coastal areas are primarily dominated by mangrove forests, which offer an intensely complex environment and species that mostly remain unexplored. In recent years, many structurally diverse compounds with unique skeletons have been identified from mangrove fungi and evaluated for their antiproliferative properties. These compounds may serve as lead molecules for the development of new anticancer drugs. Mangrove endophytes can be modulated using epigenetic means or culture optimization methods to improve the yield or to produce various similar analogs. The present review provides an insight into the bioactive metabolites from mangrove endophytes reported during the period from 2012 to 2018 (up to April, 2018) along with their cytotoxic properties, focusing on their chemical structures and mode of action, as indicated in the literature. View Full-Text
Keywords: endophytic fungi; anticancer compounds; mangroves; co-culture; epigenetic modification endophytic fungi; anticancer compounds; mangroves; co-culture; epigenetic modification

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Deshmukh, S.K.; Gupta, M.K.; Prakash, V.; Reddy, M.S. Mangrove-Associated Fungi: A Novel Source of Potential Anticancer Compounds. J. Fungi 2018, 4, 101.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
J. Fungi EISSN 2309-608X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top