Next Article in Journal
“Never Trust to General Impressions, My Boy, but Concentrate Yourself upon Details”: An Unusual and Challenging Presentation of Pheochromocytoma
Next Article in Special Issue
New Insights into the Development and Morphogenesis of the Cardiac Purkinje Fiber Network: Linking Architecture and Function
Previous Article in Journal
Comparison of Left Atrial Appendage Occlusion versus Non-Vitamin-K Antagonist Oral Anticoagulation in High-Risk Atrial Fibrillation: An Update
Previous Article in Special Issue
Regulation of Cardiac Conduction and Arrhythmias by Ankyrin/Spectrin-Based Macromolecular Complexes
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
JCDD
Volume 8
Issue 6
10.3390/jcdd8060070
jcdd-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

How Cardiac Embryology Translates into Clinical Arrhythmias

by
Mathilde R. Rivaud
1,
Michiel Blok
2,
Monique R. M. Jongbloed
2,3 and
Bastiaan J. Boukens
1,4,*
1
Department of Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Amsterdam Cardiovascular Sciences, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
2
Department of Anatomy & Embryology, Leiden University Medical Center, Einthovenweg 20, 2300 RC Leiden, The Netherlands
3
Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
4
Department of Medical Biology, Amsterdam UMC, University of Amsterdam, Amsterdam Cardiovascular Sciences, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
*
Author to whom correspondence should be addressed.
J. Cardiovasc. Dev. Dis. 2021, 8(6), 70; https://doi.org/10.3390/jcdd8060070
Submission received: 30 April 2021 / Revised: 31 May 2021 / Accepted: 1 June 2021 / Published: 13 June 2021
(This article belongs to the Special Issue Molecular Control of Development and Function of the Cardiac Conduction System)
Browse Figures
Versions Notes

Abstract

The electrophysiological signatures of the myocardium in cardiac structures, such as the atrioventricular node, pulmonary veins or the right ventricular outflow tract, are established during development by the spatial and temporal expression of transcription factors that guide expression of specific ion channels. Genome-wide association studies have shown that small variations in genetic regions are key to the expression of these transcription factors and thereby modulate the electrical function of the heart. Moreover, mutations in these factors are found in arrhythmogenic pathologies such as congenital atrioventricular block, as well as in specific forms of atrial fibrillation and ventricular tachycardia. In this review, we discuss the developmental origin of distinct electrophysiological structures in the heart and their involvement in cardiac arrhythmias.
Keywords: cardiac development; arrhythmias; re-entry; transcription factors cardiac development; arrhythmias; re-entry; transcription factors

Share and Cite

MDPI and ACS Style

Rivaud, M.R.; Blok, M.; Jongbloed, M.R.M.; Boukens, B.J. How Cardiac Embryology Translates into Clinical Arrhythmias. J. Cardiovasc. Dev. Dis. 2021, 8, 70. https://doi.org/10.3390/jcdd8060070

AMA Style

Rivaud MR, Blok M, Jongbloed MRM, Boukens BJ. How Cardiac Embryology Translates into Clinical Arrhythmias. Journal of Cardiovascular Development and Disease. 2021; 8(6):70. https://doi.org/10.3390/jcdd8060070

Chicago/Turabian Style

Rivaud, Mathilde R., Michiel Blok, Monique R. M. Jongbloed, and Bastiaan J. Boukens. 2021. "How Cardiac Embryology Translates into Clinical Arrhythmias" Journal of Cardiovascular Development and Disease 8, no. 6: 70. https://doi.org/10.3390/jcdd8060070

APA Style

Rivaud, M. R., Blok, M., Jongbloed, M. R. M., & Boukens, B. J. (2021). How Cardiac Embryology Translates into Clinical Arrhythmias. Journal of Cardiovascular Development and Disease, 8(6), 70. https://doi.org/10.3390/jcdd8060070

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop