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Coronary Vasculature in Cardiac Development and Regeneration

by Subir Kapuria 1,*, Tyler Yoshida 1,2 and Ching-Ling Lien 1,3,4,*
1
The Saban Research Institute of Children’s Hospital Los Angeles, Los Angeles, CA 90027, USA
2
Department of Biological Sciences, Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, CA 90007, USA
3
Department of Surgery, University of Southern California, Los Angeles, CA 90033, USA
4
Department of Biochemistry & Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
*
Authors to whom correspondence should be addressed.
J. Cardiovasc. Dev. Dis. 2018, 5(4), 59; https://doi.org/10.3390/jcdd5040059
Received: 1 November 2018 / Revised: 27 November 2018 / Accepted: 30 November 2018 / Published: 17 December 2018
(This article belongs to the Special Issue Cardiac Regeneration in Non-Mammalian Vertebrates)
Functional coronary circulation is essential for a healthy heart in warm-blooded vertebrates, and coronary diseases can have a fatal consequence. Despite the growing interest, the knowledge about the coronary vessel development and the roles of new coronary vessel formation during heart regeneration is still limited. It is demonstrated that early revascularization is required for efficient heart regeneration. In this comprehensive review, we first describe the coronary vessel formation from an evolutionary perspective. We further discuss the cell origins of coronary endothelial cells and perivascular cells and summarize the critical signaling pathways regulating coronary vessel development. Lastly, we focus on the current knowledge about the molecular mechanisms regulating heart regeneration in zebrafish, a genetically tractable vertebrate model with a regenerative adult heart and well-developed coronary system. View Full-Text
Keywords: heart regeneration; coronary vessels; endothelial cells; perivascular cells heart regeneration; coronary vessels; endothelial cells; perivascular cells
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Kapuria, S.; Yoshida, T.; Lien, C.-L. Coronary Vasculature in Cardiac Development and Regeneration. J. Cardiovasc. Dev. Dis. 2018, 5, 59.

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