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Reply to the Comment on: Marco Cirillo The Memory of the Heart. J. Cardiovasc. Dev. Dis. 2018, 5, 55
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Coronary Vasculature in Cardiac Development and Regeneration
Reply published on 20 December 2018, see J. Cardiovasc. Dev. Dis. 2019, 6(1), 1.
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Comment on “The Memory of the Heart”, J. Cardiovasc. Dev. Dis. 2018, 5, 55

Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne NE1 4EP, UK
J. Cardiovasc. Dev. Dis. 2018, 5(4), 60; https://doi.org/10.3390/jcdd5040060
Received: 15 November 2018 / Accepted: 8 December 2018 / Published: 19 December 2018
In his recent review for the Journal of Cardiovascular Development and Disease, Cirillo offers a concept for “cardiac memory” based on the notion that the ventricular cone can be unwrapped to show a myocardial band extending from the pulmonary to the aortic root. The concept of the myocardial band was itself developed by Torrent Guasp, and has subsequently been championed by Buckberg. Neither Torrent Guasp, when formulating his initial concept, nor Buckberg in his subsequent endorsements, have validated the results of dissection using histological or other techniques that would reveal the boundaries of the alleged band. In contrast, there is a wealth of evidence showing that such boundaries do not exist and that the cardiomyocytes are packed together within the walls of the ventricular cone in the form of a three-dimensional mesh. The evidence demonstrating the manner of packing of the cardiomyocytes within the ventricular walls was summarised in another recent review published in the journal. It is disappointing that Cirillo chose to ignore the wealth of evidence disproving the concept on which he bases his entire review. Only by recognising the existence of this evidence can we truly understand ventricular function correctly, as envisaged by Cirillo. View Full-Text
Keywords: anatomy; development; helical heart; three-dimensional mesh; ventricular mural architecture anatomy; development; helical heart; three-dimensional mesh; ventricular mural architecture
MDPI and ACS Style

Anderson, R.H. Comment on “The Memory of the Heart”, J. Cardiovasc. Dev. Dis. 2018, 5, 55. J. Cardiovasc. Dev. Dis. 2018, 5, 60.

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