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J. Cardiovasc. Dev. Dis. 2018, 5(4), 55; https://doi.org/10.3390/jcdd5040055

The Memory of the Heart

Heart Failure Surgery Unit, Cardiac Surgery Unit, Cardiovascular Department, Poliambulanza Foundation Hospital, Via Leonida Bissolati 57, 25125 Brescia, Italy
Received: 2 October 2018 / Revised: 1 November 2018 / Accepted: 8 November 2018 / Published: 11 November 2018
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Abstract

The embryological development of the heart is one of the most fascinating phenomena in nature and so is its final structure and function. The various ontogenetic passages form the evolutive basis of the final configuration of the heart. Each key step can be recognized in the final features, as the heart maintains a kind of “memory” of these passages. We can identify the major lines of development of the heart and trace these lines up to the mature organ. The aim of this review is to identify these key parameters of cardiac structure and function as essential elements of the heart’s proper functioning and bases for its treatment. We aim to track key steps of heart development to identify what it “remembers” and maintains in its final form as positively selected. A new vision based on the whole acquired knowledge must guide an in-depth scientific approach in future papers and guidelines on the topic and a complete, farsighted therapeutic conduct able to ensure the physiological correction of cardiac pathologies. The application of this modern, functional vision of the heart could improve the clinical treatment of heart disease, filling the gaps still present. View Full-Text
Keywords: heart embryology; myocardial structure; interlaced myocardial fibers; cardiomyopathy; left ventricular reconstruction; heart failure; valve disease; mitral regurgitation; guidelines; cardiac resynchronization heart embryology; myocardial structure; interlaced myocardial fibers; cardiomyopathy; left ventricular reconstruction; heart failure; valve disease; mitral regurgitation; guidelines; cardiac resynchronization
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Cirillo, M. The Memory of the Heart. J. Cardiovasc. Dev. Dis. 2018, 5, 55.

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