The Effectiveness of Commercial Vaccination against Lawsonia intracellularis in Mitigating the Reduction in ADWG, the Increased Mortality and Fecal Shedding of the Vaccinated Pigs: A Systematic Review and Meta-Analysis
Abstract
:Simple Summary
Abstract
1. Introduction
2. Methods
2.1. Search Strategy and Selection Criteria
2.2. Study Selection Process
2.3. Data Extraction
2.4. Quality Assessment
2.5. Outcome Measures
2.6. Data Analysis
3. Results
3.1. Characteristics of the Included Studies
3.2. Data Synthesis
3.2.1. ADWG
3.2.2. Fecal Shedding Rate
3.2.3. Mortality Rate
3.3. Publication Bias
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Reason | References |
---|---|
Insufficient outcome data included | Riber et al., 2011a [14], Nogueira et al., 2013 [15], Bak et al., 2009 [16], Guedes et al., 2003 [17], Jansen et al., 2019 [18], Nogueira et al., 2015 [19], Riber et al., 2011b [20], Cordes et al., 2012 [21], Roerink et al., 2018 [4] |
Studies involved with development of experimental vaccine candidates | Watson et al., 2011 [22], Watson et al., 2014 [23], Kim et al., 2017 [24], Park et al., 2019 [25], Park et al., 2018 [26], Won et al., 2018 [27], Obradovic et al., 2019 [28] |
Conference proceeding or review paper | Rathkjen et al., 2007 [29], Gaumann et al., 2005 [30], Henke et al., 2006 [31], Obradovic et al., 2020 [32], Jacobson et al., 2010 [33], Kroll et al., 2005 [34], Okones et al., 2005 [35], Klien et al., 2011 [36], Dominique et al., 2014 [37]. |
Sub-Group | No. of Trials | Point Estimate | Standard Error | Z-Value | p-Value | Heterogeneity (Total between) | |||
---|---|---|---|---|---|---|---|---|---|
Q-Value | Df (Q) | p-Value | |||||||
Production phase | Nursery | 10 | 0.256 | 0.005 | 3.580 | 0.000 | |||
Growing- finishing | 15 | 0.720 | 0.230 | 3.131 | 0.002 | ||||
3.711 | 1 | 0.054 * | |||||||
Study type | Field trial | 16 | 0.567 | 0.052 | 2.478 | 0.013 | |||
Controlled trial | 9 | 0.675 | 0.027 | 4.074 | 0.000 | ||||
0.145 | 1 | 0.703 |
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Won, G.; Chi, N.-K.; Park, Y. The Effectiveness of Commercial Vaccination against Lawsonia intracellularis in Mitigating the Reduction in ADWG, the Increased Mortality and Fecal Shedding of the Vaccinated Pigs: A Systematic Review and Meta-Analysis. Vet. Sci. 2022, 9, 536. https://doi.org/10.3390/vetsci9100536
Won G, Chi N-K, Park Y. The Effectiveness of Commercial Vaccination against Lawsonia intracellularis in Mitigating the Reduction in ADWG, the Increased Mortality and Fecal Shedding of the Vaccinated Pigs: A Systematic Review and Meta-Analysis. Veterinary Sciences. 2022; 9(10):536. https://doi.org/10.3390/vetsci9100536
Chicago/Turabian StyleWon, Gayeon, Na-Kyoung Chi, and Yebin Park. 2022. "The Effectiveness of Commercial Vaccination against Lawsonia intracellularis in Mitigating the Reduction in ADWG, the Increased Mortality and Fecal Shedding of the Vaccinated Pigs: A Systematic Review and Meta-Analysis" Veterinary Sciences 9, no. 10: 536. https://doi.org/10.3390/vetsci9100536
APA StyleWon, G., Chi, N. -K., & Park, Y. (2022). The Effectiveness of Commercial Vaccination against Lawsonia intracellularis in Mitigating the Reduction in ADWG, the Increased Mortality and Fecal Shedding of the Vaccinated Pigs: A Systematic Review and Meta-Analysis. Veterinary Sciences, 9(10), 536. https://doi.org/10.3390/vetsci9100536