Vet-OncoNet: Malignancy Analysis of Neoplasms in Dogs and Cats
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Data Origin and Structure
2.2. Malignancy Classification
2.3. Statistical Analysis
2.4. Generalized Linear Mixed Effect Models
3. Results
Mixed Effect Logistic Regression
4. Discussion
4.1. Species
4.2. Age
4.3. Topography
4.4. Breed
4.5. Sex
4.6. Geographical Distribution
4.7. Limitations of the Study
4.8. Important Notes
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Diagnosis | Malignancy Category |
---|---|
Canine cutaneous MCT [25,26] all grades | Malignant |
Feline cutaneous MCT [27] Without malignancy description With some malignancy description | Benign Malignant |
Subcutaneous MCT [26,28] all pattern descriptions | Benign |
Meibomian gland epithelioma | Malignant [29] |
All other /1 morphologies Without malignancy description With some malignancy description | Benign Malignant |
Morphologies undefined (M800) # | Not included in the analysis |
Total Tumors | Malignant Tumors | ||||
---|---|---|---|---|---|
Variable | Category | N | % | N | MP % 1 |
Total | 16,272 | 100 | 8578 | 52.7 | |
Species | |||||
Canine | 13,006 | 80.0 | 6008 | 46.2 | |
Feline | 3266 | 20.0 | 2570 | 78.7 ** | |
Sex 2 | 16,105 | 100 | 8475 | 52.6 | |
Male | 6285 | 39.0 | 3123 | 49.7 | |
Female | 9820 | 61.0 | 5352 | 54.5 ** | |
Dog | |||||
Male | 5275 | 41.0 | 2384 | 45.2 | |
Female | 7605 | 59.0 | 3552 | 46.7 ** | |
Cat | |||||
Male | 1010 | 31.3 | 739 | 73.2 | |
Female | 2215 | 68.7 | 1800 | 81.3 ** |
Variable | Category | Model 0 | Model 1 | |||
---|---|---|---|---|---|---|
OR | 95%CI | OR | 95%CI | p-Value | ||
Dogs and cats | ||||||
Species | ||||||
Canine | - | - | Ref | |||
Feline | - | - | 3.96 | (3.57, 4.39) | <0.001 | |
Age (3y) | 1.18 | (1.14, 1.23) | <0.001 | |||
Sex | ||||||
Male | - | - | Ref | |||
Female | - | - | 1.19 | (1.09, 1.30) | <0.001 | |
Random Effect | MOR | Variance | MOR | Variance | ||
Topography | 4.26 | 2.314 | 4.10 | 2.188 | ||
District | 1.09 | 0.009 | 1.14 | 0.019 | ||
Dogs | ||||||
Age (3y) | - | - | 1.24 | (1.19, 1.29) | <0.001 | |
Sex | ||||||
Male | - | - | Ref | |||
Female | - | - | 1.19 | (1.08, 1.31) | <0.001 | |
Random Effect | MOR | Variance | MOR | Variance | ||
Topography | 4.33 | 2.364 | 4.25 | 2.301 | ||
Breed | 1.53 | 0.198 | 1.56 | 0.221 | ||
District | 1.09 | 0.009 | 1.11 | 0.013 | ||
Cats | ||||||
Age (3y) | - | - | 1.23 | 1.13, 1.34 | <0.001 | |
Sex | - | - | ||||
Male | - | - | Ref | |||
Female | - | - | 0.98 | 0.77, 1.23 | 0.872 | |
Random Effect | MOR | Variance | MOR | Variance | ||
Topography | 6.44 | 3.811 | 6.05 | 3.563 | ||
Breed | 1.38 | 0.117 | 1.43 | 0.140 | ||
District | 1.19 | 0.034 | 1.19 | 0.035 |
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Pinello, K.; Amorim, I.; Pires, I.; Canadas-Sousa, A.; Catarino, J.; Faísca, P.; Branco, S.; Peleteiro, M.C.; Silva, D.; Severo, M.; et al. Vet-OncoNet: Malignancy Analysis of Neoplasms in Dogs and Cats. Vet. Sci. 2022, 9, 535. https://doi.org/10.3390/vetsci9100535
Pinello K, Amorim I, Pires I, Canadas-Sousa A, Catarino J, Faísca P, Branco S, Peleteiro MC, Silva D, Severo M, et al. Vet-OncoNet: Malignancy Analysis of Neoplasms in Dogs and Cats. Veterinary Sciences. 2022; 9(10):535. https://doi.org/10.3390/vetsci9100535
Chicago/Turabian StylePinello, Katia, Irina Amorim, Isabel Pires, Ana Canadas-Sousa, José Catarino, Pedro Faísca, Sandra Branco, Maria C. Peleteiro, Daniela Silva, Milton Severo, and et al. 2022. "Vet-OncoNet: Malignancy Analysis of Neoplasms in Dogs and Cats" Veterinary Sciences 9, no. 10: 535. https://doi.org/10.3390/vetsci9100535