Absorption of N-acetylcysteine in Healthy and Mycoplasma gallisepticum-Infected Chickens
Abstract
:1. Introduction
2. Materials and Methods
2.1. Drugs
2.2. Experimental Design
2.3. Determination of Plasma Concentrations by LC-MS/MS Analysis
2.4. Pharmacokinetic Analysis
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Parameters | Units | Geometric Mean ± SD |
---|---|---|
kab | h−1 | 0.67 ± 0.34 |
kel | h−1 | 0.21 ± 0.09 |
t1/2ab | h | 1.04 ± 0.53 |
t1/2el | h | 3.30 ± 1.43 |
Tmax | h | 2.47 ± 0.45 |
Cmax | µg mL−1 | 2.26 ± 0.91 |
AUC0-∞ | µg h mL−1 | 19.24 ± 4.25 |
Parameters | Estimates | Units | SE | CV % | 2.5% CI | 97.5% CI | |
---|---|---|---|---|---|---|---|
Groups treated solely with NAC | |||||||
Thetas (typical value) | tvka | 0.26 | 1 h−1 | 0.04 | 15.61 | 0.18 | 0.34 |
tvV | 6.65 | L kg−1 | 1.82 | 27.36 | 3.01 | 10.29 | |
tvk | 0.51 | 1 h−1 | 0.10 | 19.28 | 0.32 | 0.71 | |
stdev0 | 0.47 | µg/mL | 0.04 | 8.71 | 0.39 | 0.56 | |
All four groups | |||||||
Thetas (typical value) | tvka | 0.142 | 1 h−1 | 0.025 | 17.65 | 0.093 | 0.192 |
tvV | 1.75 | L kg−1 | 0.571 | 32.62 | 0.624 | 2.877 | |
tvk | 1.219 | 1 h−1 | 0.306 | 25.10 | 0.615 | 1.823 | |
stdev0 | 0.349 | µg/mL | 0.025 | 7.13 | 0.301 | 0.399 |
Omega | Variance | SE | BSV (CV %) | Shrinkage |
---|---|---|---|---|
Groups treated solely with NAC | ||||
ηka | 0.023 | 0.002 | 15.09 | 0.155 |
ηk | 0.057 | 0.013 | 24.15 | 0.176 |
ηV | 0.371 | 0.066 | 67.05 | 0.156 |
All four groups | ||||
ηka | 0.593 | 0.177 | 60.66 | 0.351 |
ηk | 0.576 | 0.327 | 88.21 | 0.356 |
ηV | 1.14 | 0.572 | 145.78 | 0.252 |
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Petkova, T.; Milanova, A. Absorption of N-acetylcysteine in Healthy and Mycoplasma gallisepticum-Infected Chickens. Vet. Sci. 2021, 8, 244. https://doi.org/10.3390/vetsci8110244
Petkova T, Milanova A. Absorption of N-acetylcysteine in Healthy and Mycoplasma gallisepticum-Infected Chickens. Veterinary Sciences. 2021; 8(11):244. https://doi.org/10.3390/vetsci8110244
Chicago/Turabian StylePetkova, Tsvetelina, and Aneliya Milanova. 2021. "Absorption of N-acetylcysteine in Healthy and Mycoplasma gallisepticum-Infected Chickens" Veterinary Sciences 8, no. 11: 244. https://doi.org/10.3390/vetsci8110244