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Open AccessArticle

Long-Term Effects of Dietary Olive Oil and Hydrogenated Vegetable Oil on Expression of Lipogenic Genes in Subcutaneous Adipose Tissue of Dairy Cows

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Departamento de Ciencias Animales, Facultad de Agronomía e Ingeniería Forestal, Pontificia Universidad Católica de Chile, Santiago Casilla-306, Chile
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Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Grønnegardsvej 3, C DK-1870 Frederiksberg, Denmark
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Department of Animal and Rangeland Sciences, Oregon State University, Corvallis, OR 97331, USA
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Departamento de Fomento de la Producción Animal, Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile. Av. Santa Rosa 11735, La Pintana, Santiago 8820808, Chile
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Laboratorio de Biotecnología en Alimentos, Unidad de Alimentos, Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile, Avda. El Libano 5524, Macul, Santiago, 7830490, Chile
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Milk Production, Production Systems, Natural Resources Institute Finland (Luke), 31600 Jokioinen FI, Finland
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School of Biosciences, The University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD, UK
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Department of Animal Sciences and Division of Nutritional Sciences, Mammalian NutriPhysioGenomics, University of Illinois, Urbana, IL 61801, USA
*
Authors to whom correspondence should be addressed.
Vet. Sci. 2019, 6(3), 74; https://doi.org/10.3390/vetsci6030074
Received: 8 August 2019 / Revised: 9 September 2019 / Accepted: 12 September 2019 / Published: 15 September 2019
The objective of this study was to characterize the long-term transcriptomic effects of lipogenic genes in subcutaneous adipose tissue (SAT) of dairy cows supplemented with unsaturated (olive oil; OO) and saturated (hydrogenated vegetable oil; HVO) lipids. Cows were fed a control diet with no added lipid, or diets containing OO or HVO (n = 5 cows/group) for 63 days. SAT was obtained from the tail-head area at the onset of the study and after 21, 42, and 63 days of supplementation. Treatments had minor effects on expression of measured genes. Both fat supplements reduced expression of PPARG, HVO decreased transcription of the desaturase FADS2 and lipid droplet formation PLIN2, and OO increased transcription of FABP3. Both lipid treatments decreased expression of the transcription regulator SREBF1 and its chaperone (SCAP) during the first 21 days of treatment. Our data indicated that long-term feeding of OO and HVO have a relatively mild effect on expression of lipogenic genes in SAT of mid-lactating cows. View Full-Text
Keywords: fat supplementation; transcriptomics; adipose tissue; lipid metabolism; lipogenic gene expression; dairy cows fat supplementation; transcriptomics; adipose tissue; lipid metabolism; lipogenic gene expression; dairy cows
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Vargas-Bello-Pérez, E.; Bionaz, M.; Sciarresi-Arechabala, P.; Cancino-Padilla, N.; Morales, M.S.; Romero, J.; Leskinen, H.; Garnsworthy, P.C.; Loor, J.J. Long-Term Effects of Dietary Olive Oil and Hydrogenated Vegetable Oil on Expression of Lipogenic Genes in Subcutaneous Adipose Tissue of Dairy Cows. Vet. Sci. 2019, 6, 74.

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