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Open AccessArticle

A Comparative Pharmacokinetic Analysis of Oral and Subcutaneous Meloxicam Administered to Postpartum Dairy Cows

1
ACER Consulting, Guelph, ON N1G 5L3, Canada
2
Alberta Veterinary Laboratories, Calgary, AB T2E 6J7, Canada
*
Author to whom correspondence should be addressed.
Vet. Sci. 2019, 6(3), 73; https://doi.org/10.3390/vetsci6030073
Received: 9 July 2019 / Revised: 29 August 2019 / Accepted: 31 August 2019 / Published: 5 September 2019
(This article belongs to the Section Physiology and Nutrition)
The dairy industry needs evidence-based solutions to mitigate painful procedures and conditions in dairy cattle. The objective of this study was to compare the pharmacokinetic properties of orally versus subcutaneously administered meloxicam in early-lactation dairy cattle. The study was conducted at a commercial dairy herd in southwestern Ontario, Canada. Twelve postpartum cows were enrolled in the study, receiving either subcutaneous meloxicam (MET) at 0.5 mg/kg body weight (n = 6) or oral meloxicam (MOS) at a higher dose of 1.0 mg/kg body weight (n = 6) immediately following parturition. The predicted half-life (12.5 ± 2.0 vs. 28.5 ± 2.0 h), Cmax (1.59 ± 0.15 vs. 1.95 ± 0.16 μg/mL), Tmax (5.33 vs. 11.7 h), and AUC0→∞ (39.6 ± 7.4 vs. 115.6 ± 19 h * µg/mL) differed significantly between MET and MOS cows, respectively. After controlling for the treatment group, first lactation cows had a significantly higher half-life (4.1 ± 2.1 h), Cmax (0.56 ± 0.2 µg/mL), and AUC0→∞ (21.6 ± h * µg/mL) relative to second lactation or greater cows, respectively. Administration of meloxicam through the subcutaneous or oral route results in appreciable, dose-dependent systemic levels. View Full-Text
Keywords: dairy cow; meloxicam; pharmacokinetics; non-steroidal anti-inflammatory; early lactation dairy cow; meloxicam; pharmacokinetics; non-steroidal anti-inflammatory; early lactation
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Shock, D.; Roche, S.; Olson, M. A Comparative Pharmacokinetic Analysis of Oral and Subcutaneous Meloxicam Administered to Postpartum Dairy Cows. Vet. Sci. 2019, 6, 73.

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