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Intracoronary Gene Delivery of the Cytoprotective Factor Vascular Endothelial Growth Factor-B167 in Canine Patients with Dilated Cardiomyopathy: A Short-Term Feasibility Study

1
Department of Emergency and Organ Transplantation, Section of Veterinary Clinics and Animal Production; University of Bari, 70010 Bari; Italy
2
Institute of Life Sciences, Scuola Superiore Sant’Anna, 56100 Pisa, Italy
3
Heart Center, Dresden at the Technical University of Dresden, 01067 Dresden, Germany
4
Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), 34149 Trieste, Italy
5
CNR, Institute of Clinical Physiology, Area della Ricerca, 56121 Pisa, Italy
*
Author to whom correspondence should be addressed.
Vet. Sci. 2019, 6(1), 23; https://doi.org/10.3390/vetsci6010023
Received: 14 December 2018 / Revised: 17 February 2019 / Accepted: 28 February 2019 / Published: 6 March 2019
(This article belongs to the Special Issue Italian Society of the Veterinary Sciences SISVet 2018)
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Abstract

Dilated cardiomyopathy (DCM) is a myocardial disease of dogs and humans characterized by progressive ventricular dilation and depressed contractility and it is a frequent cause of heart failure. Conventional pharmacological therapy cannot reverse the progression of the disease and, in humans, cardiac transplantation remains the only option during the final stages of heart failure. Cytoprotective gene therapy with vascular endothelial growth factor-B167 (VEGF-B167) has proved an effective alternative therapy, halting the progression of the disease in experimental studies on dogs. The aim of this work was to test the tolerability and feasibility of intracoronary administration, under fluoroscopic guidance, of VEGF-B167 carried by adeno-associated viral vectors in canine DCM patients. Ten patients underwent the gene delivery procedure. The intraoperative phase was well tolerated by all dogs. Clinical and echocardiographic assessments at 7- and 30-days post-procedure showed stable conditions compared to the pre-procedure phase. The results of this work indicate that intracoronary VEGF-B167 gene delivery is feasible and tolerated in dogs with DCM. Further monitoring/investigations are ongoing to evaluate the effects of this therapy on disease progression. View Full-Text
Keywords: clinical study; intracoronary cytoprotective gene therapy; dogs clinical study; intracoronary cytoprotective gene therapy; dogs
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Paradies, P.; Carlucci, L.; Woitek, F.; Staffieri, F.; Lacitignola, L.; Ceci, L.; Romano, D.; Sasanelli, M.; Zentilin, L.; Giacca, M.; Salvadori, S.; Crovace, A.; Recchia, F.A. Intracoronary Gene Delivery of the Cytoprotective Factor Vascular Endothelial Growth Factor-B167 in Canine Patients with Dilated Cardiomyopathy: A Short-Term Feasibility Study. Vet. Sci. 2019, 6, 23.

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