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Article

Modifications of Gut Microbiota after Grape Pomace Supplementation in Subjects at Cardiometabolic Risk: A Randomized Cross-Over Controlled Clinical Trial

1
Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), Jordi Girona 18-26, 08034 Barcelona, Spain
2
Department of Cell Biology, Physiology & Immunology, Faculty of Biology, University of Barcelona, Avinguda Diagonal 643, 08028 Barcelona, Spain
3
Department of Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition (ICTAN-CSIC), José Antonio Novais 10, 28040 Madrid, Spain
4
Departament d’Enginyeria Química i Química Analítica, Institut de Biomedicina (IBUB), Universitat de Barcelona, Carrer de Martí i Franquès, 1-11, 08028 Barcelona, Spain
*
Author to whom correspondence should be addressed.
Current affiliation: Department of Agrifood Research, Madrid Institute for Rural, Agricultural and Food Research and Development (IMIDRA), A-2 Km. 38.2, 28805 Alcalá de Henares (Madrid), Spain.
Foods 2020, 9(9), 1279; https://doi.org/10.3390/foods9091279
Received: 30 July 2020 / Revised: 1 September 2020 / Accepted: 7 September 2020 / Published: 11 September 2020
(This article belongs to the Special Issue The Health Benefits of the Bioactive Compounds in Foods)
Polyphenols are dietary bioactive compounds able to induce modifications in the gut microbiota profile, although more clinical studies are needed. With this aim, a randomized cross-over clinical trial was conducted, where 49 subjects at cardiometabolic risk (exhibiting at least two metabolic syndrome factors) were supplemented with a daily dose of 8 g of grape pomace (GP) for 6 weeks, with an equivalent control (CTL) period. The levels of total bacteria and Bacteroidetes, Firmicutes, Lactobacilliales, Bacteroides and Prevotella were estimated in fecal DNA by quantitative real-time PCR (qPCR), while fecal short-chain fatty acids (SCFAs) were assessed by gas chromatography. Several cardiometabolic markers were evaluated in blood samples. GP reduced insulin levels only in half of the participants (responders). GP supplementation did not cause significant modifications in the microbiota profile of the whole group, except for a tendency (p = 0.059) towards a decrease in the proportion of Lactobacilliales, while it increased the proportion of Bacteroides in non-responder subjects. The reduction of insulin levels in subjects at cardiometabolic risk upon GP supplementation appears not to be induced by changes in the major subgroups of gut microbiota. Further studies at the species level may help to elucidate the possible role of microbiota in GP-induced insulinemic status. View Full-Text
Keywords: metabolic syndrome; microbiota; insulin sensitivity; polyphenols; grape pomace metabolic syndrome; microbiota; insulin sensitivity; polyphenols; grape pomace
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MDPI and ACS Style

Ramos-Romero, S.; Martínez-Maqueda, D.; Hereu, M.; Amézqueta, S.; Torres, J.L.; Pérez-Jiménez, J. Modifications of Gut Microbiota after Grape Pomace Supplementation in Subjects at Cardiometabolic Risk: A Randomized Cross-Over Controlled Clinical Trial. Foods 2020, 9, 1279. https://doi.org/10.3390/foods9091279

AMA Style

Ramos-Romero S, Martínez-Maqueda D, Hereu M, Amézqueta S, Torres JL, Pérez-Jiménez J. Modifications of Gut Microbiota after Grape Pomace Supplementation in Subjects at Cardiometabolic Risk: A Randomized Cross-Over Controlled Clinical Trial. Foods. 2020; 9(9):1279. https://doi.org/10.3390/foods9091279

Chicago/Turabian Style

Ramos-Romero, Sara, Daniel Martínez-Maqueda, Mercè Hereu, Susana Amézqueta, Josep L. Torres, and Jara Pérez-Jiménez. 2020. "Modifications of Gut Microbiota after Grape Pomace Supplementation in Subjects at Cardiometabolic Risk: A Randomized Cross-Over Controlled Clinical Trial" Foods 9, no. 9: 1279. https://doi.org/10.3390/foods9091279

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