Insights on Health and Food Applications of Equus asinus (Donkey) Milk Bioactive Proteins and Peptides—An Overview
Abstract
:1. Introduction
2. Global Composition of Donkey Milk Compared to Other Types of Milk
3. Bioactive Proteins and Peptides in Donkey Milk Compared to Other Types of Milk
3.1. Caseins
3.2. β-Lactoglobulin
3.3. α-Lactalbumin
3.4. Lysozyme
3.5. Lactoferrin
3.6. Lactoperoxidase
4. Comparison between Donkey Colostrum and Donkey Milk
5. Anti-Microbial Activity of Donkey Milk
6. Antioxidant Activity of Donkey Milk
7. Anti-Inflammatory and Anti-Tumoral Activity of Donkey Milk
8. Anti-Diabetic and Anti-Obesity Activity of Donkey Milk
9. Food and Other Applications of Donkey Milk
10. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Milk Characteristics | Donkey (%) | Goat (%) | Cow (%) | Camel (%) | Human (%) |
---|---|---|---|---|---|
Proteins | 1.74 | 3.41 | 3.43 | 1.80 | 1.64 |
Fat | 1.21 | 4.62 | 3.46 | 1.80 | 3.38 |
Lactose | 6.23 | 4.47 | 4.71 | 2.91 | 6.69 |
Dry Matter | 9.61 | 13.23 | 12.38 | 11.30 | 12.43 |
Ashes | 0.43 | 0.73 | 0.78 | 0.85 | 0.22 |
Water | 90.39 | 86.77 | 87.62 | 90.60 | 87.57 |
Energy (KJ/Kg) | 1939.40 | 3399.50 | 2983.00 | 2745.80 | 2855.60 |
Cow (g/L) | Donkey (g/L) | Goat (g/L) | Camel (g/L) | Human (g/L) | |
---|---|---|---|---|---|
Total protein content | 31–38 | 13–28 | 25–39 | 25–45 | 9–17 |
Total casein | 27.2 | 6.6 | 25 | 26.4 | 5.6 |
Total whey protein | 4.5 | 7.5 | 6 | 6.6 | 8 |
αS1-casein | 10–15 | 0.2–1 | 0–7 | 5 | 0.3–0.8 |
αS2-casein | 3–4 | 0.2 | 4.2 | 2.2 | n.d. |
β-casein | 9–11 | 3.9 | 11–18 | 12.8 | 1.8–4 |
κ-casein | 3–4 | n.d. | 4–4.6 | 0.8 | 0.6–1 |
α-lactalbumin | 1–1.5 | 1.8–3 | 1.2 | 3.5 | 1.9–2.6 |
β-lactoglobulin | 3.3–4 | 3.2–3.7 | 2.1 | n.d. | n.d. |
Lysozyme | 0.00007 | 1 | Trace | 0.00015 | 0.04–0.2 |
Lactoferrin | 0.1 | 0.08 | 0.02–0.2 | 0.22 | 1.7–2 |
Immunoglobulins | 1 | n.d. | 1 | 1.54 | 1.1 |
Albumin | 0.4 | n.d. | 0.5 | 0.4 | 0.4 |
Types of Milk | |
---|---|
Donkey Colostrum | Donkey’s Mature Milk |
Zinc-alpha-2-glycoprotein | Histone H3 |
Immmunoglobulin lambda light chain variable region | Myristoylateda lanine-rich C-kinase substrate |
Thrombospondin 4 | Histone H4 |
Peptidoglycan recognition protein 1 | Multiple coagulation factor deficiency 2 |
Cartilage acidic protein 1 | C-C motif chemokine |
Peptidyl-prolyl cis-trans isomerase | Transcription factor adipocyte enhancer binding protein 1 (AEBP1) |
L receptor related protein 1 | Follistatin-like 1 |
Insulin like growth factor binding protein 7 | ST6 beta-galactoside alpha-2,6-sialyltransferase 1 |
Major histocompatibility complex (MHC) class II associated invariant chain | Uncharacterized protein |
DNA J-like protein subfamily B member 11-like protein | Multiple coagulation factor deficiency protein-like protein |
Cathepsin Z | Uncharacterized protein |
Uncharacterized protein | Glutathione peroxidase (Fragment) |
Amino peptidase |
Milk Type | Lysozyme (g/L) | Lactoperoxidase (g/L) | Lactoferrin (g/L) |
---|---|---|---|
Donkey | 1.0 | 0.11 | 0.08 |
Human | 0.12 | 0.77 | 0.3–4.2 |
Goat | Trace | Trace | 0.02–2 |
Camel | 0.00015 | n.d. | 0.22 |
Cow | 0.00007 | 30–100 | 0.10 |
Proteins/Peptide | Biological Activity | Reference |
---|---|---|
αS1- and β-casein | Antihypertensive | [73] |
Inhibitor activity of Angiotensin converting enzyme (ACE) and antioxidant activity. | [5] | |
αS1- casein | Transport calcium phosphate | UniProtKB—P86272 |
αS2- casein | Transport calcium phosphate | UniProtKB—B7VGF9 |
Lysozyme | Anti-inflammatory properties | [63] |
Anti-tumoral properties | [77] | |
Reduced incidence of diarrhea | [83] | |
Anti-microbial properties | [32] | |
Lactoferrin | Antmicrobial properties | [57] |
Antitumor | [73] | |
Antithrombotic | [74] | |
Lactoperoxidase | Antioxydant properties | [61] |
Anti-microbial properties | [57] | |
α-lactalbumine | Anti-diabetic properties | [76] |
Antihypertensive | [74] | |
β-lactoglobuline | Antihypertensive | [74] |
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Derdak, R.; Sakoui, S.; Pop, O.L.; Muresan, C.I.; Vodnar, D.C.; Addoum, B.; Vulturar, R.; Chis, A.; Suharoschi, R.; Soukri, A.; et al. Insights on Health and Food Applications of Equus asinus (Donkey) Milk Bioactive Proteins and Peptides—An Overview. Foods 2020, 9, 1302. https://doi.org/10.3390/foods9091302
Derdak R, Sakoui S, Pop OL, Muresan CI, Vodnar DC, Addoum B, Vulturar R, Chis A, Suharoschi R, Soukri A, et al. Insights on Health and Food Applications of Equus asinus (Donkey) Milk Bioactive Proteins and Peptides—An Overview. Foods. 2020; 9(9):1302. https://doi.org/10.3390/foods9091302
Chicago/Turabian StyleDerdak, Reda, Souraya Sakoui, Oana Lelia Pop, Carmen Ioana Muresan, Dan Cristian Vodnar, Boutaina Addoum, Romana Vulturar, Adina Chis, Ramona Suharoschi, Abdelaziz Soukri, and et al. 2020. "Insights on Health and Food Applications of Equus asinus (Donkey) Milk Bioactive Proteins and Peptides—An Overview" Foods 9, no. 9: 1302. https://doi.org/10.3390/foods9091302