Agaricus brasiliensis KA21 May Prevent Diet-Induced Nash Through Its Antioxidant, Anti-Inflammatory, and Anti-Fibrotic Activities in the Liver
by
Anna Nakamura 1,2, Qi Zhu 2,3, Yoko Yokoyama 1,2, Naho Kitamura 1,2, Sena Uchida 1,2, Kayo Kumadaki 1,2, Kazuo Tsubota 2,4,*
and Mitsuhiro Watanabe 1,2,3,*
Anna Nakamura 1,2, Qi Zhu 2,3, Yoko Yokoyama 1,2, Naho Kitamura 1,2, Sena Uchida 1,2, Kayo Kumadaki 1,2, Kazuo Tsubota 2,4,* and Mitsuhiro Watanabe 1,2,3,*
1
Systems Biology Program, Graduate School of Media and Governance, Keio University, Kanagawa 252-0882, Japan
2
Health Science Laboratory, Keio Research Institute at SFC, Kanagawa 252-0882, Japan
3
Department of Environment and Information Studies, Keio University, Kanagawa 252-0882, Japan
4
Department of Ophthalmology, Keio University School of Medicine, Tokyo 160-8582, Japan
*
Authors to whom correspondence should be addressed.
Foods 2019, 8(11), 546; https://doi.org/10.3390/foods8110546
Received: 12 September 2019 / Revised: 18 October 2019 / Accepted: 28 October 2019 / Published: 4 November 2019
(This article belongs to the Section Food Nutrition)
Non-alcoholic steatohepatitis (NASH) is a progressive disease that occurs in the liver. As the number of people with NASH has increased, effective prevention and treatment strategies are needed. Agaricus brasiliensis KA21 (AGA) is a mushroom native to Brazil and is considered a healthy food because of its purported health benefits, including its antioxidant properties. In this study, we focused on the oxidative stress that accompanies the onset of NASH and examined whether AGA can prevent NASH development through its antioxidant activity. We used a mouse model of NASH in which pathogenesis was promoted by dietary induction. Supplementation with AGA attenuated the development of hepatic fibrosis, which is a characteristic feature of late-stage NASH. This effect appeared to be mechanistically linked to an AGA-promoted reduction in hepatic oxidative stress. These results demonstrate a novel role for AGA in NASH prevention.
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Keywords:
non-alcoholic steatohepatitis; non-alcoholic fatty liver disease; Agaricus brasiliensis KA21; anti-oxidant; anti-inflammation
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MDPI and ACS Style
Nakamura, A.; Zhu, Q.; Yokoyama, Y.; Kitamura, N.; Uchida, S.; Kumadaki, K.; Tsubota, K.; Watanabe, M. Agaricus brasiliensis KA21 May Prevent Diet-Induced Nash Through Its Antioxidant, Anti-Inflammatory, and Anti-Fibrotic Activities in the Liver. Foods 2019, 8, 546.
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