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Review

Research Progress on the Nutritional Components, Bioactivity, Health Effects, and Food Applications of Passion Fruit Peel (PFP)

1
School of Food Science and Engineering, Guiyang University, Guiyang 550005, China
2
College of Biological and Environmental Engineering, Guiyang University, Guiyang 550005, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Foods 2025, 14(19), 3397; https://doi.org/10.3390/foods14193397
Submission received: 28 August 2025 / Revised: 26 September 2025 / Accepted: 29 September 2025 / Published: 30 September 2025
(This article belongs to the Section Food Nutrition)

Abstract

Passion fruit peel (PFP) is a common byproduct of industrial passion fruit processing, yet it serves as a valuable source of diverse bioactive compounds and nutrients. However, limited attention has been paid in the literature to the nutritional properties and practical applications of PFP. This review summarizes methods for extracting bioactive substances from PFP, examines their potential health benefits, and explores their prospects for utilization in the food industry. Recent studies have quantified various bioactive components, such as flavonoids, vitamins, and dietary fiber (DF), while reporting the corresponding extraction yields or concentrations. Furthermore, these compounds exhibit significant potential in promoting human health, including antioxidant, anti-inflammatory, and gut health-improving effects. The analysis also highlights the bioavailability of bioactive constituents in PFP. Consequently, PFP presents a promising yet underexplored area for scientific research, though substantial challenges remain in optimizing its utilization, enhancing extraction efficiency, and advancing innovative applications.

1. Introduction

Passion fruit (Passiflora edulis Sims) belongs to the Passifloraceae family of the Passiflora genus and is widely distributed in tropical America, Asia and Africa. Generally, passion fruit can be classified into purple-skinned passion fruit and yellow-skinned passion fruit based on its appearance [1]. It is the third most popular tropical fruit in the world after mangoes and pineapples [2,3,4]. Numerous reviews have documented the nutritional value, phytochemistry, and pharmacological properties of Passiflora species [5,6]. Passion fruit is rich in bioactive compounds, including polysaccharides, carotenoids, polyphenols, and flavonoids, and exhibits diverse health-promoting properties such as antioxidant, anti-inflammatory, antidiabetic, and antitumor activities [7,8,9,10]. Both the fresh fruit and its juice are consumed as dietary sources of essential nutrients and functional components [11,12].
However, as the passion fruit processing industry continues to evolve, a critical issue that warrants attention is the disposal of by-products generated during this process. Globally, approximately 40% of passion fruit is utilised for industrial processing. The peel that is produced during this process accounts for approximately 50% to 60% of the fruit’s total weight, thus representing a significant by-product. Drawing upon the example of China, it is evident that the substantial processing volume results in the generation of nearly one million tonnes of peel on an annual basis. PFP constitutes the primary by-product and retains a substantial proportion of the active components inherent in passion fruit. It is rich in bioactive compounds, including polyphenolic substances (e.g., gallic acid), acidic polysaccharides (e.g., pectin), flavonoids, and natural pigments [13,14,15]. The recovery and utilization of PFP present significant application potential within the food industry—such as in pectin extraction and functional food development—as well as in the creation of bio-based materials [16]. Of particular importance is the prospect for further utilizing PFP as part of a promising sustainable trend aimed at enhancing the value of agro-industrial by-products. Furthermore, research into the development and utilization of food processing by-products has emerged as a prominent area both domestically and internationally. Recent literature has reviewed various aspects related to such by-products—including apple pomace and banana peel—which have found extensive applications across both food and pharmaceutical industries [17,18]. Additionally, recent studies have demonstrated that certain industrial by-products, such as apple pomace and sugarcane bagasse, can be effectively utilized in producing bread, confectionery items, and extruded snacks [19].
Despite the extensive research conducted on the functional characteristics and health effects of PFP, a key research limitation remains the insufficient understanding of its bioavailability. This limitation also constrains its innovative applications in the food sector. Consequently, there is an urgent need for a comprehensive analysis of the health benefits associated with the active components found in PFP as well as their bioavailability. In summary, this paper provides an overview of extraction methods, active characteristics, bioavailability, and practical applications of nutritional components derived from PFP in food. It also discusses the limitations and challenges encountered in the development of PFP while ultimately proposing a promising strategy for future development. As a valuable resource with significant potential, the comprehensive utilization of PFP components is particularly crucial. The proposed utilization method represents a promising approach that merits further attention, research, and practical application in future endeavors.

2. Nutrients

PFP is rich in a diverse array of nutrients, particularly vitamins, DF, and minerals. These components can provide the human body with essential nutrients while serving as a cost-effective source of nutrition. The nutritional composition of PFP is presented in Table 1.

2.1. Carbohydrates and Dietary Fiber

Carbohydrates are of pivotal significance in the provision of energy to the human body. Fiber polysaccharides represent a category of complex carbohydrates that are present in plant-based foods. These polysaccharides are composed of dietary fibers that are recalcitrant to human enzymes, including cellulose, hemicellulose, pectin, and β-glucan. While these non-starch polysaccharides do not directly provide energy, they are nevertheless essential for digestive health and can also regulate blood sugar and cholesterol levels [20]. Xylitol, a widely used sugar substitute, has also been demonstrated to offer numerous health advantages [21]. Infante-Neta et al. [22] identified that PFP contains substantial amounts of cellulose, which can be utilized for xylitol production. By optimizing the production conditions, the yield of xylitol was increased to 14.97 g/L, thereby establishing it as a highly promising raw material for xylitol synthesis. Furthermore, Guimarães et al. [23] reported that PFP contains reducing sugars at a concentration of 3.06 ± 0.12 g/100 g.
DF is widely acknowledged as the seventh essential nutrient, playing a crucial role in human physiological functions through mechanisms such as the regulation of gut microbiota and the enhancement of satiety [24]. PFP serves as a raw material that is rich in DF, with studies reporting levels reaching up to 71.79 g/100 g [8]. Liu et al. [25] discovered that the SDF content in PFP amounted to 20.51%, demonstrating significant physiological benefits. In addition, Fonseca et al. [26] reported that purple passion fruit peel (PPFP) contains an exceptionally high level of DF, with concentrations reaching 577 g/kg. Presently, research on the extraction of DF from PFP is underway, and a substantial number of clinical trials have validated the efficacy of DF in addressing obesity and diabetes while promoting gut health. However, further comprehensive research is necessary to validate any potential side effects or interactions with other medications.

2.2. Vitamins

Vitamins are essential nutrients required by the human body and play a crucial role in vital bodily functions [27]. Notably, the vitamins found in passion fruit are predominantly present in the juice, with lower concentrations detected in the peel. In a study conducted by Dos Reis et al. [28], a comparison was made between the vitamin A (VA) content of yellow passion fruit peel (YPFP) and PPFP. The results indicated that PPFP exhibited the highest concentration of VA, averaging 59.69 ± 2.55 μg/100 g. Furthermore, Guimarães et al. [23] reported that PPFP contains 28.07 ± 0.77 mg of vitamin C (VC) /100 g. These findings suggest that incorporating PPFP into food formulations may aid in achieving the recommended daily intake of 45 mg as established by WHO/FAO.

2.3. Minerals, Lipids, and Proteins

In addition to common carbohydrates, DF, and lipids, PFP also contains small amounts of proteins, as well as minerals and trace elements. The protein and lipids present in passion fruit are predominantly located in the seeds, with only negligible quantities found in PFP. Gamarra-Castillo et al. [29] reported a protein content of 7.571 ± 0.232%. In contrast, do Prado Ferreira and Tarley [30] determined that PFP contained 8410 mg/100 g of total lipids. Furthermore, Dos Reis et al. [28] conducted a comprehensive analysis of the mineral composition of YPFP and PPFP, revealing that YPFP exhibited higher concentrations of phosphorus (P) and sulfur (S) compared to PPFP; conversely, PPFP demonstrated elevated levels of sodium (Na), magnesium (Mg), potassium (K), Zinc (Zn), and calcium (Ca) (see Table 1). This discrepancy may be attributed to differences in varietal composition. To date, there has been a paucity of research on the nutritional distinctions between PPFP and YPFP. Therefore, exploring the differences between PFP from various species or color variants is essential for the broader application of PFP.
Table 1. Nutrient Content in PFP.
Table 1. Nutrient Content in PFP.
NutrientOriginContentReferences
CarbohydrateYPFP85.78 ± 0.00 g/100 g[27]
PPFP80.71 ± 0.00 g/100 g[27]
PPFP76 g/kg[25]
PPFP78.267 ± 0.517%[29]
DFYPFP45.18 ± 0.83 g/100 g[13]
YPFP61.16 ± 1.02 g/100 g[27]
PPFP61.68 ± 1.31 g/100 g[27]
PPFP577 g/kg[25]
PPFP62.459 ± 2.857%[29]
YPFP69.69 ± 0.88 g/100 g[31]
VAYPFP22.71 ± 0.98 μg/100 g[27]
PPFP59.69 ± 2.55 μg/100 g[27]
VCPPFP4.58 g/kg[25]
PYPFP140 ± 1.30 mg/100 g[27]
PPFP70,00 ± 1.12 mg/100 g[27]
PFP240 ± 1.71 mg/100 g[27]
SYPFP7000 ± 0.40 mg/100 g[27]
PPFP160 ± 1.35 mg/100 g[27]
NaYPFP2.20 ± 0.02 mg/100 g[27]
PPFP7.30 ± 0.12 mg/100 g[27]
PPFP54.107 mg/kg[29]
MgYPFP120 ± 0.90 mg/100 g[27]
PPFP130 ± 0.97 mg/100 g[27]
PPFP1.60 g/kg[25]
PPFP836.964 mg/kg[29]
KYPFP2600 ± 15.7 mg/100 g[27]
PPFP2800 ± 16.3 mg/100 g[27]
PPFP31,065.357 mg/kg[29]
CaYPFP250 ± 1.98 mg/100 g[27]
PPFP310 ± 1.69 mg/100 g[27]
PPFP2833.036 mg/kg[29]
YPFP0.226 g/100 g[31]
ZnPPFP6.071 mg/kg[30]
LipidYPFP4.20 ± 0.02 g/100 g[13]
PFP3.47 ± 0.3 g/100 g[29]
PPFP6 g/kg[25]
PFP8410 mg/100 g[29]
ProteinYPFP3.14 ± 0.31 g/100 g[13]
YPFP3.40 ± 0.06 g/100 g[23]
PPFP6.47 ± 0.04 g/100 g[27]
PFP8.41 ± 0.1 g/100 g[29]
PPFP34 g/kg[25]
PPFP7.571 ± 0.232%[29]

3. Phytochemical Composition

PFP is a rich source of bioactive compounds, rendering it an excellent candidate for various applications. Understanding the functions of these compounds is crucial for optimizing their utilization across different industrial sectors. Therefore, it is essential to develop a comprehensive understanding of the mechanisms that underlie the bioactive properties of PFP. These compounds include polyphenols such as gallic acid and neochlorogenic acid, as well as flavonoids and carotenoids like β-carotene and lutein. Table 2 outlines the composition of PFP’s active components.

3.1. Polysaccharides

Polysaccharides encompass pectin, cellulose, hemicellulose, and other compounds. Pectin is a heteropolysaccharide with diverse industrial applications in sectors such as food, agriculture, medicine, and biomedicine [32]. Galacturonic acid constitutes the primary component of pectin from PFP, representing approximately 65% of the total pectin content. It can be classified into high-methoxy pectin (HMP) and low-methoxy pectin (LMP) based on the degree of methylation. HMP undergoes conversion to LMP through deesterification—a process that is crucial for minimizing sugar usage in food applications while also influencing the physiological functions of pectin [33,34,35]. Teng et al. [36] conducted an analysis of the composition of pectic polysaccharides extracted from PPFP using two distinct methods via gas chromatography. The study revealed that the monosaccharide composition predominantly includes galacturonic acid, glucose, xylose, arabinose, galactose, and rhamnose. Moreover, the findings indicated that different extraction methods significantly affect monosaccharide composition; specifically, pectin extracted using ultrasonic-assisted techniques exhibited elevated levels of galacturonic acid along with enhanced antioxidant and anti-inflammatory activities. This phenomenon is attributed to the ultrasonic-assisted extraction method’s ability to better preserve the activity of heat-sensitive compounds. Teles et al. [37] found that the majority of pectin components extracted from YPFP were primarily composed of high galacturonic acid polysaccharides (HG), rhamnogalacturonic acid polysaccharide I (RGI), rhamnogalacturonic acid polysaccharide II (RGII), and xylogalacturonic acid polysaccharides (XG). A comparative analysis of the pectin composition in YPFP and PPFP with that reported by Teng et al. [36] indicates a significant degree of similarity. Furthermore, Teles et al. [37] quantified cellulose content at 51.99% and hemicellulose at 18.93% in PFP. Liang et al. [38] utilized ultrasound-assisted extraction techniques to extract PPFP, resulting in pectin with increased total pectin content and reduced methylation levels, thereby enhancing the stability of the extracted pectin. Concurrently, Zhao et al. [39] and Liang et al. [38] demonstrated that variations in extraction methodologies can lead to changes in both structural and physical properties of pectin within PFP, significantly influencing its practical applications. Consequently, developing appropriate extraction methodologies is essential for advancing the utilization of pectin.

3.2. Total Phenolics (TPC) and Total Flavonoid (TFC) Compounds

Vo et al. [40] demonstrated that the combination of natural deep eutectic solvents (NADES) with ultrasound-assisted extraction (UAE) or microwave-assisted extraction (MAE) technologies can effectively extract phenolic and terpenoid compounds from PFP. In comparison to their previous methods employing UAE or MAE in isolation [41], the use of NADES resulted in a significant enhancement in extraction efficiency. Under optimized UAE conditions, the yields of total terpenoids (TTC) and TPC reached 56.9 mg ursolic acid (UA)/g dry weight (dw) and 21.03 mg gallic acid equivalent (GAE)/g dw, respectively. Under optimized MAE conditions, TTC and TPC were recorded at 32.82 mg UA/g dw and 22.12 mg GAE/g dw, respectively. Huo et al. [42] further employed NADES to optimize both UAE and MAE processes, successfully isolating various phenolic compounds from YPFP, including gallocatechin, epicatechin, and myricetin. Among these compounds, gallic acid was identified as the most abundant, with a concentration of 26.29 μg/g. Notably, the TPC of PPFP was found to be significantly higher than that of other parts of the fruit, highlighting its potential as a valuable source for phenolic enrichment. Furthermore, Siniawska and Wojdyło [43] isolated 51 polyphenolic compounds from PPFP using LC-QTOF/ESI-MS. The identified compounds primarily included flavonoids (25 compounds, accounting for 52%), flavanols (8 compounds, accounting for 16%), flavan-3-ols (6 compounds, accounting for 7%), phenolic acids (4 compounds, accounting for 3%), and anthocyanins (7 types, accounting for 21%). Da Costa et al. [44] further observed that PPFP exhibits the highest polyphenol content during its mature stage, with chlorogenic acid levels reaching 45.04 ± 6.49 mg/100 g and catechin at 11.39 mg/100 g. These concentrations surpass those found in seeds and pulp, thereby confirming that PPFP serves as a significant reservoir of phenolic compounds. This conclusion was further supported by Fonseca et al. [26], who detected TPC levels ranging from 225.6 to 255.3 mg GAE/100 g in PPFP, a level significantly higher than that observed in other parts, accompanied by high antioxidant activity. Additionally, a substantial body of research has corroborated the diversity and functionality of phenolic compounds present in passion fruit. Dominguez-Rodriguez et al. [45] employed a pressurized hot water extraction method to identify a total of 57 phenolic compounds across four varieties of passion fruit, with TPC values ranging from 5.08 to 30.19 mg GAE/g. Carmona-Hernandez et al. [46] identified 16 major compounds in their study, including phenolic acids, flavonoids, catechins, and anthocyanins (notably catechin, epicatechin, and ferulic acid). They confirmed that these extracts can mitigate intestinal damage by inhibiting inflammation. Furthermore, Guimarães et al. [23] demonstrated that the phenolic content in passion fruit peel reaches 19.94 mg GAE/100 g and exhibits an impressive antioxidant capacity of 87.07%, thereby underscoring its significant physiological functional value. In summary, passion fruit peel can be regarded as an excellent source of phenolic compounds with beneficial physiological functions for human health.

3.3. Natural Pigments

The natural pigment content in PFP is significantly higher than in the fruit pulp, with cyanidin-3-glucoside (C3G) being the primary anthocyanin component. Research evidence indicates that Gamarra-Castillo et al. [29] found that the anthocyanin content of dried passion fruit peel (0.156 mg C3G/g) was significantly lower than that of fresh peel (0.535 mg C3G/g), suggesting that thermal drying significantly degrades anthocyanins. This aligns with the instability of anthocyanins at high temperatures—high temperatures can disrupt their molecular structure, leading to the loss of antioxidant activity. Ghada et al. [47] optimized the extraction process using ethanol as a solvent, achieving an anthocyanin yield of 9 ± 1 mg C3G/g from PPFP. Additionally, Kawasoe et al. [48] further identified the core pigments in PPFP as including: C3G (9.8 μg/10 mg freeze-dried sample), delphinidin-3-glucoside, and cyanidin derivatives (such as cyanidin-3-rhamnoside). The aforementioned study confirmed that pigments extracted from passion fruit peel exhibit excellent stability under light and heat treatment, making them suitable for use in jelly coloring. The coloring effect achieved through this method is comparable to that of synthetic pigments, while also contributing to the reduction of food waste (such as peels) and lowering production costs. Dos Reis et al. [28] conducted a comparative analysis of three distinct types of passion fruit, revealing that those with an orange hue exhibited the highest total carotenoid content, with β-carotene levels reaching 21,274 ± 676 μg/100 g—significantly higher than those observed in yellow and purple varieties (p < 0.05). Furthermore, components such as lutein and zeaxanthin demonstrated accumulation patterns specific to each variety. In summary, passion fruit peel has been identified as a sustainable source of C3G—a natural pigment with considerable commercial value due to its high color intensity combined with notable biological activity, including antioxidant properties. This characteristic positions it as a promising natural alternative to synthetic dyes while highlighting the significant potential for high-value utilization of agricultural byproducts.
Table 2. Content of bioactive components in PFP.
Table 2. Content of bioactive components in PFP.
Bioactive IngredientsOriginExtractionContentReferences
PectinYPFPAcid extraction37.67 ± 0.97 g/100 g[28]
PPFPAcid extraction32.85 ± 1.20 g/100 g[28]
PPFPUltrasound-assisted conventional extraction12.67%[28]
PFPHigh-pressure heating and conventional heating14.34%[49]
PFPEnzymatic extraction26 g/100 g[50]
PFPSubcritical water and pressurized natural deep eutectic solvents15.70%[51]
PFPMagnetic induction electric field treatment to assist three-phase distribution6.58%[52]
TPCPPFPOrganic solvent extraction24 ± 1 mg GAE/g[26]
PFPUltrasound-assisted pressurized liquid extraction2.07 ±0.05 mg GAE/g[53]
Gallic acidPPFPL-Proline: Citric Acid (Pro-CA) Extract8.22 ± 0.15 μg/g[42]
EpicatechinPPFPL-Proline: Citric Acid (Pro-CA) Extract2.74 ± 0.08 μg/g[42]
QuercetinYPFPAcid extraction760.21 ± 32.07 mg/100 g[28]
PPFPL-Proline: Citric Acid (Pro-CA) Extract1.57 ±0.14 μg/g[42]
RutinPPFPL-Proline: Citric Acid (Pro-CA) Extract6.66 ± 0.73 μg/g[42]
CarotenoidPFPUltrasound-assisted extraction of vegetable oils1176.195 μg/100 g[54]
YPFPOrganic solvent extraction918.41 ± 36.81 μg/100 g[28]
PPFPOrganic solvent extraction1244 ± 52.5 μg/100 g[28]
AnthocyaninPPFPAcid extraction103,686.48 ± 542.11 μg/100 g[28]
PPFPMicrowave-assisted extraction0.156 ± 0.0024 mg C3G/g[29]
PPFPSolvent extraction577.59 mg C3G 100/g[55]
Cellulose nanocrystalsPFPAcid extraction58.1 ± 1.7%[56]

4. Biological Effects

Plants have been shown to be rich in various bioactive substances, including phenolic compounds, carotenoids, and polysaccharides. These substances have been demonstrated to possess a variety of significant physiological regulatory functions in the human body, including substantial antioxidant activity, anti-inflammatory effects, and the capacity to enhance intestinal health. The biological effects of PFP are shown in Table 3.

4.1. Antioxidant

During the processes of growth and development, ROS are frequently generated. These ROS have the potential to damage cells, thereby accelerating cellular aging and contributing to oxidative stress. Excessive levels of ROS have been shown to have detrimental effects on human health, including the onset of cancer and cardiovascular diseases [57,58]. Consequently, the scavenging of ROS is a critical factor in maintaining human health. PFP contains a diverse array of phenolic compounds and flavonoids that exhibit significant antioxidant capacity. Da Costa et al. [44] identified that PFP comprises catechins, chlorogenic acid, gallic acid, resveratrol, caffeic acid, ferulic acid, among other polyphenols and flavonoids capable of effectively scavenging reactive oxygen species [59]. In addition to phenolic compounds and flavonoids, certain pectin polysaccharides have demonstrated remarkable antioxidant properties. Teng et al. [36] reported that two novel pectin polysaccharides, PFSP60 and UPFSP60, extracted from PPFP significantly enhanced the scavenging capacity for DPPH, ABTS, and superoxide anion radicals. Notably, the antioxidant activity increased with rising concentrations of these polysaccharides. Furthermore, the monosaccharide composition and glycosidic bonds of these two distinct polysaccharides were found to differ. In summary, UPFSP60 exhibited a higher galacturonic acid content and lower molecular weight compared to PFSP60, resulting in stronger antioxidant and anti-inflammatory activities. Outama et al. [60] conducted a study investigating the effects of PFP on the immune system and antioxidant activity in Nile tilapia. Following administration of PSPP20 at a dosage of 20 g/kg over periods of 4 and 8 weeks, significant differences were observed in the expression levels of immune- and antioxidant-related genes such as lbp, gst-α, and gpx. Notably, PSPP20 displayed the highest expression levels among all tested samples. Dos Reis et al. [28] evaluated the antioxidant capacity of PFP of various colors using methods such as ABTS and DPPH, revealing that YPFP exhibited a significantly higher antioxidant capacity compared to orange PFP and PPFP. Dominguez-Rodriguez et al. [45] identified 57 phenolic compounds, among which flavonoids, chalcones, and phenolic acids may be critical determinants of the antioxidant capacity of PFP, demonstrating substantial antioxidant activity. Figure 1 illustrates the antioxidant mechanisms of polyphenols in PFP. In summary, PFP possesses remarkable antioxidant capacity and high free radical scavenging rates, rendering it an appropriate raw material for pharmaceuticals or functional foods.

4.2. Anti-Inflammatory

Recent studies have shed light on the anti-inflammatory properties of PFP. Belmonte-Herrera et al. [61] demonstrated that PFP treatment (8 mg/mL in drinking water) effectively reduced colitis-induced damage in female C57BL/6J mice. Their biochemical and molecular analyses revealed that PFP not only suppressed pro-inflammatory cytokine expression but also strengthened the intestinal protective barrier. Interestingly, the treatment also boosted short-chain fatty acid production—these metabolites are known to play a crucial role in maintaining colonic homeostasis. Since microbial imbalance can trigger immune responses leading to mucosal damage and intestinal inflammation, these findings strongly support PFP’s prebiotic potential (Figure 2). Building on this, Teng et al. [36] identified two novel pectic polysaccharides (PFSP60 and UPFSP60) in PFP that exhibited both antioxidant and anti-inflammatory activities by downregulating pro-inflammatory factors. Meanwhile, Siniawska & Wojdyło [43] took the research further by isolating 51 bioactive compounds from PFP extracts, confirming through in vitro studies their significant anti-inflammatory and antioxidant effects. While the collective evidence clearly positions PFP as a potent anti-inflammatory agent due to its rich bioactive profile, we still don’t fully understand how it modulates human inflammatory factors. This knowledge gap presents an exciting avenue for future research.

4.3. Improvement of Intestinal Health

In the study conducted by Yu, Wu et al. [14], pectic polysaccharides (PFP-T and PFP-UM) were extracted from YPFP using three-phase partitioning and ultrasonic–microwave synergistic three-phase partitioning, respectively. The in vitro simulated digestion experiment revealed an increase in the total relative abundance of the intestinal flora in the phylum of thick-walled bacteria and Bacteroidetes. Compared to PFP-UM, PFP-T exhibited a superior capacity to promote the proliferation of beneficial bacteria, including Prevotella, Eubacterium, and Ruminococcus. Simultaneously, it inhibited the growth of potentially harmful bacteria such as Escherichia coli and Shigella while enhancing short-chain fatty acid production. In addition, Lubis et al. [62] investigated the effects of adding pectin to feed on the intestinal health of Nile tilapia (Oreochromis niloticus) and found that the addition of pectin not only had positive effects on the growth performance, enhancement of innate immunity, up-regulation of antioxidants and expression of immune-related genes, but also included positive changes in intestinal morphology and intestinal microbiota (Figure 3).
Jiang et al. [63] also found the same finding that passion fruit improves gut health from multiple perspectives. Ju et al. [64] showed better results relative to PFP by adding 3% enzymatically PFP (EFP) contrast to PFP in the feed of triple-yellow chickens, which, by ameliorating inflammation, could improve the health of broiler chickens by increasing the diversity of microorganisms in the cecum. Furthermore, both PFP and EPF supplementation promoted serum antioxidant status and anti-inflammatory activity to varying degrees. This finding was confirmed after analysis of the gut microbiota and metabolites, where antioxidant-related metabolites (ganoderic acid, γ-CEHC, S-adenosylmethionine), anti-inflammatory-related metabolites (OEA), and anti-inflammatory-associated bacteria (Butyricaceae) were found to be increased with EPF supplementation. Moreover, the addition of 3% EPF to the diet had a positive effect on the biosynthesis of phenylpropanes, which is strongly associated with antioxidant and anti-inflammatory properties. This was also confirmed by Pimisa, Prasongsuk et al. [65] through in vitro experiments on the potential of PFPEP and the combination of PFP/probiotics in modulating the intestinal microbiota and its metabolic activity in healthy adults, when added to PFP and PFP/probiotics.
In their analysis of the reparative effects of SDF extracted from PFP, da Silva et al. [66] found that SDF could combine with 5-FU to have a therapeutic effect on intestinal mucositis. They conducted mouse experiments to ascertain whether SDF preserved 5-FU-induced colonic length and histological damage. The results of these experiments demonstrated that SDF significantly restored 5-FU-induced intestinal oxidative stress and inflammation, as well as the enlargement and swelling of the spleen. In contrast, da Silveira et al. [67] conducted experimental research on mice, in which the animals were orally fed pectin fibres extracted from YPFP. The results of this study indicated that this led to an effect on the intestinal barrier and a worsening of sepsis in mice. In this study, despite the capacity of YPF to modulate inflammation (by increasing PELF IL-6 and small intestinal IL-10 and decreasing small intestinal TNF-α production and leukocyte accumulation in the peritoneum) and oxidative stress (by attenuating PELF LPO and TAC levels), the fibres were unable to prevent sepsis-induced mortality and hypothermia. Instead, they accelerated mortality and hypothermia in mice with infectious disease. This paradoxical result may be due to a slower disruption of the intestinal barrier [68].
Xu et al. [69] selected PFP fermentation extract, which increased gastrointestinal transport capacity and fecal water content, protected the structural integrity of colonic tissues, and reduced inflammatory infiltration. They demonstrated that its active ingredient, Kae, had preventive and relieving effects on constipation and hemorrhoids. The precise mechanisms by which PFP and its active ingredient Kae regulate the ESR1 and PI3K/Akt pathways to ameliorate constipation and hemorrhoids remain to be elucidated. Further exploration into the mechanisms of other active ingredients is warranted to ascertain their potential to improve constipation.

4.4. Additional Biological Effects

Fonseca et al. [5] identified gamma-aminobutyric acid (GABA) in PPF methanol extracts, which is associated with antihypertensive activity, with concentrations ranging from 2.40 to 4.40 mg/g. Diabetes is a chronic endocrine disorder that disrupts normal metabolic processes and bodily functions. For many years, it has been hypothesized that plant-based products rich in bioactive compounds (such as phenolic compounds, coumarins, and terpenoids) have the potential to lower blood glucose levels [70,71]. Siniawska & Wojdyło [43] demonstrated that a mixture of PPFP compounds exhibited inhibitory effects on enzyme activity by inhibiting α-amylase, α-glucosidase, and lipase; this plays a significant role in the prevention and treatment of obesity. Similarly, Vuolo et al. [72] reported that PFP can decrease inflammatory cytokines in serum, mitigate oxidative stress, and alleviate chronic inflammatory responses as well as fat deposition. Cabral et al. [73] employed liquid chromatography-triple quadrupole mass spectrometry (LC-QqQ-MS/MS) to identify five C-glycosylated flavonoids—visenin-2, kaempferol, isokaempferol, quercetin, and isoquercetin—in extracts derived from PFP. When compared to insulin monotherapy, the combination of the extract with insulin as an adjunctive therapy exhibited a significant improvement in glycemic control within a 60-day period (p < 0.05). Furthermore, this combination was found to prevent renal and cardiac complications in rats with type 1 diabetes. De Oliveira Balthar et al. [74] also reported that pectin and fiber extracted from PFP can be effective in treating type 2 diabetes. PFP contains soluble fibers such as pectin, which enhance DF intake and contribute to reductions in glucose levels and circulating lipids among diabetic patients. Hu et al. [75] investigated the anti-fatigue properties of anthocyanins purified from PPFP in mice. Their results indicated that PFE significantly extended the duration of forced swimming under load while simultaneously reducing levels of lactate dehydrogenase (LDH), blood lactate (BLA), and blood urea nitrogen (BUN). Additionally, it was observed that liver glycogen (LG) content increased following treatment with PPFP. Moreover, PPFP has been shown to mitigate fluctuations in oxidative stress biomarkers such as malondialdehyde (MDA), antioxidant enzymes including superoxide dismutase (SOD), and inflammatory cytokines like TNF-α, IL-1β, and IL-6. Furthermore, PFEA has been shown to upregulate the mRNA expression of PGC-1α and PPARα in skeletal muscle. In summary, the findings of this study indicate that supplementation with PFEA can mitigate fatigue effects. Nerdy and Ritarwan [76] reported that the hepatoprotective and nephroprotective activities of PPFP extract were superior to those observed with red passion fruit peel extract and YPFP extract. The study also demonstrated that the hepatoprotective effects of PFP are linked to its phytochemical constituents, including flavonoids and polyphenols. Additionally, PFP has been found to exhibit a range of physiological activities, such as anti-aging properties, memory enhancement, antibacterial effects, and acceleration of wound healing [77,78,79,80].
Table 3. Biological Effects in PFP.
Table 3. Biological Effects in PFP.
Physiological FunctionResearch MaterialResearch TypeMechanism of ActionReferences
AntioxidantPFPIn vitro studyEliminate ROS, such as DPPH, ABTS, and superoxide anion radicals[44]
PFSP60, UPFSP60In vitro studyEnhance the ability to scavenge free radicals[36]
PFPAnimal experimentUp-regulate the expression of antioxidant genes[60]
Anti-inflammatoryPFPFAnimal experimentInhibit pro-inflammatory cytokines, enhance the intestinal barrier, and increase short-chain fatty acids[61]
PFSP60, UPFSP60In vitro studyDown-regulate the expression of pro-inflammatory factors[36]
PFPIn vitro studyIt has anti-inflammatory and antioxidant activities[43]
Improve intestinal healthYPFPIn vitro digestion simulationPromote beneficial bacteria (Prevosiella, Megalococcus) and inhibit harmful bacteria (Escherichia, Shigella)[14]
YPFPAnimal experimentImprove intestinal morphology and microbiota, and enhance immunity[62]
PFPFAnimal experimentIncrease the diversity of cecal microorganisms and enhance antioxidant and anti-inflammatory metabolic properties[64]
PFPAnimal experimentRelieve intestinal mucositis caused by 5-FU, reduce oxidative stress and inflammation[66]
PFPAnimal experimentImprove constipation, protect colon structure, and reduce inflammatory infiltration[69]
Lower blood sugarPFPIn vitro studyInhibit α-amylase, α-glucosidase and pancreatic lipase[43]
PFPAnimal experimentImprove blood sugar control and protect heart and kidney functions[73]
PFPAnimal experimentLower blood sugar and circulating lipids[74]
Anti-fatiguePPFPAnimal experimentReduce lactic acid and urea nitrogen, increase liver glycogen, and improve oxidative stress and inflammation[75]
Liver protection and kidney protectionPPFPAnimal experimentIt is superior to other colors of PFP and is related to the content of polyphenols and flavonoids[76]
Other functionsPFPA variety of studiesAnti-aging, improve memory, antibacterial and so on[77,78,79]

5. Bioavailability/Bioaccessibility

In the field of pharmacology, bioavailability represents a multifaceted concept that encompasses both the rate of gastrointestinal transport and the extent to which a substance is absorbed into systemic circulation. The U.S. Food and Drug Administration (FDA) provides a detailed definition of bioavailability: “Bioavailability refers to the rate and extent to which the active ingredient or active portion of a drug is absorbed and reaches the site of action” [81]. It is essential to recognize that assessments of bioavailability can be performed in vitro using specialized cell lines or in vivo utilizing animal models and human biological fluids [82].
Cao et al. [83] conducted an in vitro gastrointestinal simulation digestion study to assess the residual content of phenolic compounds in PPFP extracts. The results indicated a significant reduction in TPC, TFC, and anthocyanin content following simulated digestion. Notably, the levels of TPC and flavonoids that were retained and reached the colon after digestion were substantially higher than those absorbed in the small intestine; specifically, the BI value (the amount absorbed in the small intestine) was less than 20%, while the RID value (the amount reaching the colon post-digestion) exceeded four times that of the BI value. Although the bioavailability of phenolic compounds entering the dialysis bag is low, their antioxidant capacity may offer protective effects on damaged pancreatic cells. PFP extracts have demonstrated considerable antioxidant capacity as well as α-glucosidase inhibitory activity. Furthermore, research has shown that fermentation enhances the bioavailability of peel components. Nguyen et al. [84] measured the phenolic content of PFP extracts and found that after fermentation with Aspergillus niger, their TPC was four times greater than that of unfermented extracts. Subsequent in vitro simulated digestion tests revealed increased phenolic content and bioavailability for fermented peel compared to its unfermented counterpart, suggesting that fermented PFP holds promise as a novel functional food. De Souza et al. [85] investigated the in vitro digestibility of PFP and found that, compared to other samples, PFP exhibited a capacity to delay glucose absorption in the body. Do Prado Ferreira and Tarley [33] analyzed the bioavailability of PFP during saliva, gastric, and gastrointestinal phases through in vitro simulated digestion experiments. They also examined the bioavailability of minerals (Mn, Zn, Cu, Fe, Ca, and Mg) present in flour post-digestion. The bioavailability of various elements differs significantly; this variation may be attributed to chemical bonds and specific chemical reactions involved. Following gastrointestinal digestion, Mg, Mn, and Fe were identified as contributing most substantially to bioavailable concentrations at 14%, 52%, and 12%, respectively.

6. The Application in the Food Industry

The various bioactive properties of PFP establish its potential as a functional food ingredient. The addition of precise quantities of PFP to foodstuffs has been demonstrated to effect alterations in their characteristics. Consequently, this section offers a synopsis of the potential of PFP in food-related applications. The utilization of PFP in the domain of food is delineated in Table 4.

6.1. Wheat Flour Foods

Passion fruit peel powder, which is rich in dietary fibre and polyphenolic compounds, demonstrates significant potential as a high-performance nutritional fortifier and natural functional ingredient in flour-based foods. A plethora of studies have not only corroborated its feasibility for addition, but have also delved deeper into its mechanisms of action and unique advantages.
In the domain of baked goods, Macedo et al. [86] proposed a methodologically innovative approach. Yellow passion fruit peel powder was incorporated into flour, and cookies and cakes made from this mixture exhibited high DPPH radical scavenging activity, with a total phenolic content of 645.54 mg GAE/100 g. A significant advancement was the employment of paper spray mass spectrometry, a method that facilitated the systematic identification of 22 organic compounds in the fortified flour. This study provides a comprehensive chemical analysis of the bioactive compounds present in passion fruit peel, thereby offering substantial scientific evidence for enhancing the nutritional value of baked goods. In a similar vein, Sampaio et al. [87] incorporated varying amounts of PFP (8.5–17%) into cookies to assess its impact on sensory quality, enhancing the nutritional value of the product and yielding higher sensory quality compared to conventional cookies. The albedo-rich regions, which correspond to white portions of the fruit, respectively, have been identified as promising low-cost DF additives due to their versatility in various applications. Beyond the realm of nutritional enhancement, the functional properties of PFP merit equal consideration. Ning et al. [88] conducted a study to ascertain the effects of purple passion fruit peel powder on the characteristics of biscuit digestion. The findings of the study indicated that the augmentation of PPFP addition exhibited a substantial inhibitory effect on starch hydrolysis in biscuits. This observation suggests the possibility of delaying the elevation of postprandial blood glucose levels. Concurrently, the content of biscuit polyphenols and antioxidant capacity exhibited a linear increase with the addition of PFP, thus elevating its application beyond the scope of dietary fibre supplementation to that of functional food development.
Moreover, PFP incorporation has been demonstrated to enhance the technical properties of products. As demonstrated in the studies conducted by Garcia et al. [89] and Nascimento et al. [90], a significant increase in dietary fibre content was observed in dough and finished products when conventional flour was partially replaced with PFP (up to 30%). Concurrently, these studies indicated that there was an effective reduction in both lipid content and total calories. This development not only fulfils market demands for healthy, low-calorie foods, but also offers novel approaches to addressing dietary needs for individuals with gluten sensitivity or those requiring high-fibre diets. Nasution et al. [91] utilised passion fruit peel extract as a natural antioxidant and antimicrobial agent, combining it with tilapia bone collagen to prepare pancakes. This development led to the successful expansion of PFP’s application boundaries into the domain of food preservation and safety. Its inhibitory effects on Escherichia coli and Staphylococcus aureus demonstrate its potential as a synthetic preservative alternative.

6.2. Dairy Products

In the dairy industry, passion fruit peel, notable for its substantial pectin content, functions as a multifunctional additive and fat substitute. It has been demonstrated to enhance texture and flavour in low-fat products, thereby addressing deficiencies in these areas.
As demonstrated by Liu et al. [92], PFP has been shown to enhance both the sensory and nutritional qualities of yoghurt. It was established that the incorporation of passion fruit peel powder into goat milk yogurt resulted in a substantial augmentation of the total phenolic content, total flavonoids, and anthocyanins present within the product. This increase directly led to a notable enhancement in the antioxidant activity of the yogurt. Moreover, optimal addition levels (1%) enhanced the yogurt’s taste and flavour profile, addressing the common issue of negative sensory impacts from functional ingredient additions and providing a reference for developing highly acceptable functional dairy products.
However, more in-depth mechanistic research is provided by the work of Yu et al. [93]. A novel study was conducted in which the effects of passion fruit peel pectin and commercial citrus pectin in low-fat yoghurt were systematically compared for the first time. The findings demonstrated that, even at low addition levels (0.025%), passion fruit peel pectin achieved or surpassed the effects of 0.05% citrus pectin, significantly increasing lactic acid bacteria counts, titratable acidity, and improving yogurt rheology and textural properties. The primary significance of this study is the revelation of its mechanism of action, which is as follows: the pectin from passion fruit peel forms stronger complexes with casein through electrostatic interactions, thereby constructing a more stable protein gel network. This theoretical framework not only elucidates the superior synergistic performance of the solution but also substantiates its technical feasibility as an efficient and economical fat replacement solution. The solution has been shown to maintain excellent product stability throughout a 21-day storage period. Yang et al. [35] further expanded the application prospects of the subject through the modification of pectin. The production of low-methoxyl pectin was achieved through the utilisation of plasma-assisted enzymatic methods, incorporating dielectric barrier discharge plasma. The resulting product exhibited enhanced apparent viscosity, thermal stability, and gelling properties. This modification specifically optimised pectin’s functional characteristics, rendering it particularly suitable for gel-based low-fat dairy products and indicating the potential for developing a new generation of customized food ingredients.

6.3. Other Products

Moreover, due to its elevated pectin content, PFP is frequently utilized as a thickening and gelling agent, making it particularly suitable for jelly production [94]. Caroline et al. [95] employed pectin extracted from PFP in the formulation of goji berry jelly, incorporating goji berries as a primary ingredient. Following an extensive sensory evaluation, the overall ratings consistently surpassed 80%, indicating that the product is considered appropriate for both production and consumption. Garrido et al. [96] conducted a series of physicochemical and microbiological analyses on the final product, determining that a combination of 1% PFP and 4% insulin yielded optimal results while remaining within national regulatory limits. Furthermore, Pimisa, Bankeeree et al. [97] discovered that passion fruit sourced from Thailand exhibits a higher degree of esterification, which enhances its suitability for probiotic growth and positively influences sensory quality. Additionally, PFP was found to improve TPC, antioxidant capacity (AOC), and the survival rate of probiotics throughout the storage process in synbiotic ice cream (SIC) products. These findings highlight the potential of PFP as a promising functional ingredient for SIC applications with prospective uses in the food industry or related sectors. Gamarra-Castillo et al. [29] also incorporated PPFP into beverage production to enhance their nutritional value. Their research supports the development of new products characterized by high antioxidant capacity and associated health benefits through the use of PPFP.

6.4. Food Packaging

Converting the by-products of passion fruit peels into edible or biodegradable packaging materials is a cutting-edge direction for achieving their high-value utilization and reducing plastic pollution.
The early research by Munhoz et al. [98] affirmed the environmental advantages of using yellow passion fruit by-products to produce films, but also pointed out the challenge of short shelf life due to their high biodegradability. The significance of this work lies in clarifying the core issue that must be addressed in developing such materials: the balance between durability and functionality. Nguyen et al. [99]’s research represents a significant advancement in this direction. They developed cross-linked passion fruit peel pectin/chitosan/pepper leaf composite films for the biodegradable preservation of eggplants. These films not only exhibit satisfactory mechanical properties but, more importantly, demonstrate significant antibacterial activity. The breakthrough of this technology lies in the ingenious integration of the film-forming property of pectin, the antibacterial property of chitosan, and the functionality of plant extracts through multi-component composites and cross-linking techniques, successfully preparing an intelligent packaging material that combines physical protection and biological antibacterial activity, providing a green solution for post-harvest preservation of fruits and vegetables. Currently, the application of PFP in the preservation of fruits and vegetables remains limited; nevertheless, it holds substantial market potential.

6.5. Application of High-Value-Added Products

PFP has a dual application: it is utilized in both food production and industrial diesel production. Tarigan et al. [100] demonstrated that PFP can serve as a catalyst for producing diesel at room temperature, thereby reducing the cost of diesel production. Furthermore, PFP has been successfully employed as a heterogeneous catalyst in the synthesis of palm oil biodiesel. Barros et al. [101] reported that calcined PFP possesses a high concentration of potassium (>69%), primarily in the forms of KCl and K2CO3. A comparative analysis between traditional catalysts and PFP highlights the latter’s significant potential to lower biodiesel production costs, attributed to its derivation from waste materials and its recyclability. Silva et al. [102] assessed the cellulase production by Aspergillus oryzae URM5620 and explored its application as an enzymatic pretreatment for PFP to enhance anaerobic biogas production. The PFase activity of the enzyme produced with 3% substrate and 1% glucose was measured at 1.2 U/mL and 1.7 U/mL CMCase, respectively. The biogas production potential of two hydrolyzates was compared; hydrolyzate 1 yielded 97.02 mL, which is approximately 60% higher than hydrolyzate 2’s yield of 59.9 mL. This finding suggests that optimizing biogas production represents a more achievable goal. These results indicate that fermentation pretreatment utilizing Aspergillus oryzae holds promise for enhancing and accelerating the biological digestion process of lignocellulosic organic waste.
Table 4. Applications of PFP in food.
Table 4. Applications of PFP in food.
FoodsAddition AmountKey FindingsReferences
Flour100%DPPH↑, TPC↑, color↓[86]
Biscuits 8.5–17%protein↑, ash content↑, DF↑, sensory quality↑[87]
30%DF↑, microbial content↓[88]
0–9%DPPH↑, TPC↑, DF↑, color↓[89]
10–30%vitamins↑, minerals↑, DF↑[90]
Wrap1–3 mLAntioxidant content↑, antibacterial properties↑[91]
Noodles0–9%DPPH↑, TPC↑, DF↑[11]
Yogurt0–2.5%TPC↑, TFC↑, flavonoid glycoside↑, flavor↑[92]
0.025%, 0.05%lactic acid bacteria↑, WHC↑, texture↑, apparent viscosity↑, dynamic viscoelasticity↑, flavor↑[14]
0–0.4%stability↑, lipid↓[35]
Jelly1, 3, 5%Escherichia coli↓, yeast↓, mold↓[96]
Ice cream0.4, 0.8%TPC↑, Antioxidant capacity↑, Probiotic survival rate↑[97]
Beverage0.025%anthocyanin↑[29]
73.2 gDF↑, Antioxidant capacity↑[103]
Note: In the table, the arrow “↑” indicates an increase (upward adjustment), while “↓” indicates a decrease (downward adjustment).

7. Challenges and Future Perspectives

Despite the promising potential of PFP, several significant challenges hinder its full-scale application and necessitate further research. A summary of the main challenges and the required research focus is presented in Figure 4. Firstly, the instability and low bioavailability of its bioactive compounds present a major obstacle to their effective use. There is an urgent need for more research to elucidate the bioavailability, cellular uptake mechanisms, and precise modes of action of these active ingredients within the host organism. In particular, additional evidence is necessary to clarify the mechanisms by which phenolic compounds, such as flavonoids and chlorogenic acid, exert their health-promoting effects.
Furthermore, current research on the biological effects of PFP remains constrained by numerous limitations. Investigations have predominantly focused on phenotypic changes and gene expression, leaving a significant gap in our understanding of the molecular mechanisms through which these compounds modulate intracellular signaling pathways. Moreover, research on the separation and extraction methods for these substances from PFP remains limited and underdeveloped, indicating a need for more efficient and scalable techniques.
From an application standpoint, there is a scarcity of high-value-added PFP-derived products with well-defined health benefits in the market, coupled with an underdeveloped supply chain. Addressing these issues—by deepening the mechanistic understanding, improving extraction technologies, and developing viable products and supply chains—will be a focal point for future research. Overcoming these challenges is essential to fully unlock the application potential and added value of PFP in the food industry.

8. Conclusions

PFP is characterized by a high content of bioactive compounds, including pectin, polyphenols, dietary fiber, and essential minerals. The enhanced utilization of PFP has the potential to contribute significantly to the reduction of agricultural waste and environmental pollution. This paper has reviewed recent advancements in the extraction of active components from PFP, their documented biological effects, and their emerging applications in the food sector. Evidence indicates that PFP serves as a valuable source of nutrients and bioactives for future diets, with the extracted components demonstrating various beneficial properties for human health, such as antioxidant, anti-diabetic, anti-cancer, anti-inflammatory, and antibacterial effects. Consequently, the utilization of PFP holds considerable promise within the food industry, with potential applications in functional beverages, nutritional products, plant-based meat alternatives, and as a source of natural pigments. In summary, PFP is regarded as a promising functional food raw material due to the multifunctional properties inherent in its bioactive components.

Author Contributions

L.B.: Writing—original draft, Project administration; C.L.: Methodology, Writing—review & editing; X.L.: Formal analysis; S.C.: Supervision; D.L.: Investigation, Conceptualization. All authors have read and agreed to the published version of the manuscript.

Funding

This research was funded by Guizhou Province Science and Technology Support Program Project {Qian Ke He Zhi Cheng (No. [2021] General 119)}, the Guizhou Key Laboratory of Agricultural Biosecurity [Qian Ke He ZSYS (2025) 024], the sixth batch of “Thousand” level innovative talent projects in Guizhou Province (Zhu Ke He Tong GCC [2022]008).

Institutional Review Board Statement

Not applicable.

Informed Consent Statement

Not applicable.

Data Availability Statement

No new data were created or analyzed in this study.

Conflicts of Interest

The authors declare no conflict of interest.

Abbreviations

The following abbreviations are used in this manuscript:
AbbreviationFull Term
PFPPassion fruit peel
DFDietary Fiber
PPFPPurple Passion Fruit Peel
VAVitamin A
YPFPYellow Passion Fruit Peel
VCVitamin C
PPhosphorus
SSulfur
NaSodium
MgMagnesium
KPotassium
ZnZinc
CaCalcium
HMPHigh-Methoxy Pectin
LMPLow-Methoxy Pectin
HGHigh Galacturonic Acid Polysaccharides
RGIRhamnogalacturonic Acid Polysaccharide I
RGIIRhamnogalacturonic Acid Polysaccharide II
XGXylogalacturonic Acid Polysaccharides
TPCTotal Phenolics
TFCTotal Flavonoid
NADESNatural Deep Eutectic Solvents
UAEUltrasound-assisted Extraction
TTCTotal Terpenoids
UAUrsolic Acid
dwDry Weight
GAEGallic Acid Equivalent
C3GCyanidin-3-Glucoside
EFPEnzymatically PFP
OEAAnti-Inflammatory-Related Metabolites
SDFSoluble Dietary Fiber
GABAGamma-Aminobutyric Acid
CPCitrus Pectin
SICSynbiotic Ice Cream

References

  1. Cubillo, Q.M.; Díaz, V.S.; Quirós, O.J.; Valverde, A.V.; León, S.R. Antioxidant and Antibacterial Potential of Passiflora edulis (Passion fruit) at Three Ripening Stages for Waste Valorization. Molecules 2025, 30, 3454. [Google Scholar] [CrossRef]
  2. Ma, D.N.; Dong, S.S.; Zhang, S.C.; Wei, X.Q.; Xie, Q.J.; Ding, Q.S.; Xia, R.; Zhang, X.T. Chromosome-level reference genome assembly provides insights into aroma biosynthesis in passion fruit (Passiflora edulis). Mol. Ecol. Resour. 2021, 21, 955–968. [Google Scholar] [CrossRef]
  3. Anderson, J.D.; Vidal, R.F.; Brym, M.; Stafne, E.T.; Resende, M.F.R.; Viana, A.P.; Chambers, A.H. Genotyping-by-sequencing of passion fruit (Passiflora spp.) generates genomic resources for breeding and systematics. Genet. Resour. Crop Evol. 2022, 69, 2769–2786. [Google Scholar] [CrossRef]
  4. Pereira, Z.C.; dos Anjos Cruz, J.M.; Corrêa, R.F.; Sanches, E.A.; Campelo, P.H.; de Araújo Bezerra, J. Passion fruit (Passiflora spp.) pulp: A review on bioactive properties, health benefits and technological potential. Food Res. Int. 2023, 166, 112626. [Google Scholar] [CrossRef]
  5. Fonseca, A.M.A.; Geraldi, M.V.; Junior, M.R.M.; Silvestre, A.J.D.; Rocha, S.M. Purple passion fruit (Passiflora edulis f. edulis): A comprehensive review on the nutritional value, phytochemical profile and associated health effects. Food Res. Int. 2022, 160, 111665. [Google Scholar] [CrossRef] [PubMed]
  6. Zhang, J.; Tao, S.Y.; Hou, G.G.; Zhao, F.L.; Meng, Q.G.; Tan, S.P. Phytochemistry, nutritional composition, health benefits and future prospects of Passiflora: A review. Food Chem. 2023, 428, 136825. [Google Scholar] [CrossRef] [PubMed]
  7. Rai, S.; Nagar, J.C.; Mukim, M. Pharmacological and medicinal importance of Passiflora edulis: A review. Int. J. Res. Rev. 2022, 9, 114–124. [Google Scholar] [CrossRef]
  8. Weyya, G.; Belay, A.; Tadesse, E. Passion fruit (Passiflora edulis Sims) by-products as a source of bioactive compounds for non-communicable disease prevention: Extraction methods and mechanisms of action: A systematic review. Front. Nutr. 2024, 11, 1340511. [Google Scholar] [CrossRef]
  9. de Isabella, D.A.E.; Dragan, M.; Karla, B.T.; de Oliveira, L.D.L.; Maria, C.A. Brazilian passion fruit as a new healthy food: From its composition to health properties and mechanisms of action. Food Funct. 2021, 12, 10498–10514. [Google Scholar] [CrossRef]
  10. Reguengo, L.M.; do Nascimento, R.D.P.; de Faria Machado, A.P.; Junior, M.R.M. Signaling pathways and the potential anticarcinogenic effect of native Brazilian fruits on breast cancer. Food Res. Int. 2022, 155, 111117. [Google Scholar] [CrossRef]
  11. Ning, X.; Zhou, Y.H.; Wang, Z.; Zheng, X.D.; Pan, X.L.; Chen, Z.L.; Liu, Q.P.; Du, W.; Cao, X.H.; Wang, L. Evaluation of passion fruit mesocarp flour on the paste, dough, and quality characteristics of dried noodles. Food Sci. Nutr. 2022, 10, 3247–3258. [Google Scholar] [CrossRef] [PubMed]
  12. Sun, Y.; Shuai, L.; Luo, D.; Ba, L. The inhibitory mechanism of eugenol on Lasiodiplodia theobromae and its induced disease resistance of passion fruit. Agronomy 2023, 13, 1408. [Google Scholar] [CrossRef]
  13. Lopez-Martinez, L.X.; Villegas-Ochoa, M.A.; Dominguez-Avila, J.A.; Yahia, E.M.; Gonzalez, G.A. Techno-Functional and bioactive properties and chemical composition of guava, mamey sapote, and passion fruit peels. Pol. J. Food Nutr. Sci. 2023, 73, 173–218. [Google Scholar] [CrossRef]
  14. Yu, Y.H.; Wu, L.B.; Liu, X.Z.; Zhao, L.C.; Li, L.Q.; Jin, M.Y.; Yu, X.Y.; Liu, F.Y.; Li, Y.T.; Li, L.; et al. In vitro simulated digestion and fermentation characteristics of pectic polysaccharides from fresh passion fruit (Passiflora edulis f. flavicarpa L.) peel. Food Chem. 2024, 452, 139606. [Google Scholar] [CrossRef]
  15. Alim, M.A.; Mondal, S.; Khan, M.F.; Mamia, M.M.; Shohan, M.A.R.; Miah, M.P.; Khan, T.; Kabir, M.H.; Rahman, M.N.; Akther, F. Comparative analyses of proximate composition, bioactive compound and antioxidant activity in different parts of green and ripe passion fruit. Carpathian J. Food Sci. Technol. 2023, 15, 42–52. [Google Scholar] [CrossRef]
  16. Viera, W.; Shinohara, T.; Samaniego, I.; Sanada, A.; Terada, N.; Ron, L.; Suárez-Tapia, A.; Koshio, K. Phytochemical composition and antioxidant activity of Passiflora spp. germplasm grown in Ecuador. Plants 2022, 11, 328. [Google Scholar] [CrossRef]
  17. Zhang, F.; Wang, X.; Wang, T.; Lu, X. Apple pomace as a potential valuable resource for full-components utilization: A review. J. Clean. Prod. 2021, 329, 129676. [Google Scholar] [CrossRef]
  18. Choudhury, N.; Nickhil, C.; Deka, S.C. Comprehensive review on the nutritional and therapeutic value of banana by-products and their applications in food and non-food sectors. Food Biosci. 2023, 56, 103416. [Google Scholar] [CrossRef]
  19. Raczkowska, E.; Serek, P. Health-Promoting properties and the use of fruit pomace in the food industry—A review. Nutrients 2024, 16, 2757. [Google Scholar] [CrossRef]
  20. Clemente-Suárez, V.J.; Mielgo-Ayuso, J.; Martín-Rodríguez, A.; Ramos-Campo, D.J.; Redondo-Flórez, L.; Tornero-Aguilera, J.F. The burden of carbohydrates in health and disease. Nutrients 2022, 14, 3809. [Google Scholar] [CrossRef]
  21. Wlnerhanssen, B.K.; Meyer-Gerspach, A.C.; Beglinger, C.; Islam, M.S. Metabolic effects of the natural sweeteners xylitol and erythritol: A comprehensive review. Crit. Rev. Food Sci. Nutr. 2020, 60, 1986–1998. [Google Scholar] [CrossRef]
  22. Infante-Neta, A.A.; de Carvalho, Á.A.O.; D’Almeida, A.P.; Gonçalves, L.R.B.; de Albuquerque, T.L. Xylitol production from passion fruit peel hydrolysate: Optimization of hydrolysis and fermentation processes. Bioresour. Technol. 2024, 414, 131628. [Google Scholar] [CrossRef] [PubMed]
  23. Guimarães, M.L.L.; Viana, E.B.M.; da Silva, L.E.; Zanuto, M.E.; de Souza, C.C.E. Coprodutos agroindustriais de maracujá do mato (Passiflora cincinnata Mast): Qualidade nutricional e funcional. Res. Soc. Dev. 2023, 12, e1281242788. [Google Scholar] [CrossRef]
  24. Kaspari, M. The seventh macronutrient: How sodium shortfall ramifies through populations, food webs and ecosystems. Ecol. Lett. 2020, 23, 1153–1168. [Google Scholar] [CrossRef] [PubMed]
  25. Liu, Z.; Wang, X.; Li, Q.; Kang, X.; Li, Y.; Gong, C.; Liu, Y.; Chen, H. Physiological functions of the by-products of passion fruit: Processing, characteristics and their applications in food product development. Foods 2025, 14, 1643. [Google Scholar] [CrossRef]
  26. Fonseca, A.M.A.; Silvestre, A.J.D.; Rocha, S.M. From physicochemical characteristics variability to purple passion fruit (Passiflora edulis f. edulis) powders nutritional value: On the path of zero-waste. J. Sci. Food Agric. 2025, 105, 1234–1245. [Google Scholar] [CrossRef]
  27. Barker, T. Vitamins and Human Health: Editorial. Nutrients 2025, 17, 1534. [Google Scholar] [CrossRef]
  28. Dos Reis, L.C.R.; Facco, E.M.P.; Salvador, M.; Flôres, S.H.; de Oliveira, R.A. Antioxidant potential and physicochemical characterization of yellow, purple and orange passion fruit. J. Food Sci. Technol. 2018, 55, 2679–2691. [Google Scholar] [CrossRef]
  29. Gamarra-Castillo, O.; Hernández-Carrión, M.; Sánchez-Camargo, A.D.P. Revalorization of purple passion fruit peel: Compositional analysis, anthocyanin microwave-assisted extraction, and beverage application. Future Foods. 2025, 11, 100536. [Google Scholar] [CrossRef]
  30. Ferreira, M.D.P.; Tarley, C.R.T. Bioaccessibility estimation of metallic macro and micronutrients Ca, Mg, Zn, Fe, Cu and Mn in flours of oat and passion fruit peel. LWT Food Sci. Technol. 2021, 150, 111880. [Google Scholar] [CrossRef]
  31. Cibele, F.D.O.; Giordani, D.; Lutckemier, R.; Gurak, P.D.; Cladera-Olivera, F.; Marczak, L.D.F. Extraction of pectin from passion fruit peel assisted by ultrasound. LWT Food Sci. Technol. 2016, 71, 110–115. [Google Scholar] [CrossRef]
  32. Freitas, C.M.P.; Coimbra, J.S.R.; Souza, V.G.L.; Sousa, R.C.S. Structure and applications of pectin in food, biomedical, and pharmaceutical industry: A review. Coatings 2021, 11, 922. [Google Scholar] [CrossRef]
  33. Freitas, C.M.P.; Sousa, R.C.S.; Dias, M.M.S.; Coimbra, J.S.R. Extraction of pectin from passion fruit peel. Food Eng. Rev. 2020, 12, 293–306. [Google Scholar] [CrossRef]
  34. Santos, E.E.; Amaro, R.C.; Bustamante, C.C.C.; Guerra, M.H.A.; Soares, L.C.; Froes, R.E.S. Extraction of pectin from agroindustrial residue with an ecofriendly solvent: Use of FTIR and chemometrics to differentiate pectins according to degree of methyl esterification. Food Hydrocoll. 2020, 107, 105921. [Google Scholar] [CrossRef]
  35. Yang, Y.; Zhang, W.X.; Ai, B.L.; Zheng, L.L.; Zheng, X.Y.; Xiao, D.; Sheng, Z.W.; Yang, J.S.; Wang, S.W. Passion fruit peel-derived low-methoxyl pectin: De-esterification methods and application as a fat substitute in set yogurt. Carbohydr. Polym. 2025, 347, 122664. [Google Scholar] [CrossRef]
  36. Teng, H.; He, Z.G.; Li, X.Y.; Shen, W.D.; Wang, J.H.; Zhao, D.; Sun, H.; Xu, X.L.; Li, C.L.; Zha, X.Q. Chemical structure, antioxidant and anti-inflammatory activities of two novel pectin polysaccharides from purple passion fruit (Passiflora edulia Sims) peel. J. Mol. Struct. 2022, 1264, 133309. [Google Scholar] [CrossRef]
  37. Teles, G.H.; dos Santos, E.C.; da Silva, G.B.; da Silva, M.G.L.; da Silva, J.M.; Rocha, G.J.D.M.; Pita, W.D.B.; Ribeiro, E. Full utilization of the yellow passion fruit peel: Chemical characterization and valorization to reduce biomass waste. Ind. Crops Prod. 2023, 206, 117593. [Google Scholar] [CrossRef]
  38. Liang, Y.L.; Yang, Y.; Zheng, L.L.; Zheng, X.Y.; Xiao, D.; Wang, S.W.; Ai, B.L.; Sheng, Z.W. Extraction of pectin from passion fruit peel: Composition, structural characterization and emulsion stability. Foods 2022, 11, 3995. [Google Scholar] [CrossRef]
  39. Zhao, L.C.; Wu, L.B.; Li, L.Q.; Zhu, J.; Chen, X.; Zhang, S.Y.; Li, L.; Yan, J.K. Physicochemical, structural, and rheological characteristics of pectic polysaccharides from fresh passion fruit (Passiflora edulis f. flavicarpa L.) peel. Food Hydrocoll. 2023, 136, 108301. [Google Scholar] [CrossRef]
  40. Vo, T.P.; Phan, T.H.; Nguyen, T.H.P.; Nguyen, V.K.; Dang, T.C.T.; Nguyen, L.G.K.; Chung, T.Q.; Nguyen, H.Q.; Chau, P.T.T.; Thinh, L.D.A.; et al. Green extraction of phenolics and terpenoids from passion fruit peels using natural deep eutectic solvents. J. Food Process. Eng. 2024, 47, e14503. [Google Scholar] [CrossRef]
  41. Vo, T.P.; Nguyen, N.T.U.; Le, V.H.; Phan, T.H.; Nguyen, T.H.Y.; Nguyen, D.Q. Optimizing ultrasonic-assisted and microwave-assisted extraction processes to recover phenolics and flavonoids from passion fruit peels. ACS Omega 2023, 8, 37226–37239. [Google Scholar] [CrossRef]
  42. Huo, D.X.; Dai, J.C.; Yuan, S.Y.; Cheng, X.Q.; Pan, Y.G.; Wang, L.; Wang, R.M. Eco-friendly simultaneous extraction of pectins and phenolics from passion fruit (Passiflora edulis Sims) peel: Process optimization, physicochemical properties, and antioxidant activity. Int. J. Biol. Macromol. 2023, 243, 125229. [Google Scholar] [CrossRef]
  43. Siniawska, M.; Wojdyło, A. Polyphenol profiling by LC QTOF/ESI-MS and biological activity of purple passion fruit epicarp extract. Molecules 2023, 28, 6711. [Google Scholar] [CrossRef] [PubMed]
  44. Costa, C.A.R.D.; Machado, G.G.L.; Rodrigues, L.J.; Barros, H.E.A.D.; Natarelli, C.V.L.; Boas, E.V.D.B.V. Phenolic compounds profile and antioxidant activity of purple passion fruit’s pulp, peel and seed at different maturation stages. Sci. Hortic. 2023, 321, 112244. [Google Scholar] [CrossRef]
  45. Dominguez-Rodriguez, G.; Garcia, M.C.; Plaza, M.; Marina, M.L. Revalorization of Passiflora species peels as a sustainable source of antioxidant phenolic compounds. Sci. Total Environ. 2019, 696, 134030. [Google Scholar] [CrossRef]
  46. Carmona-Hernandez, J.C.; Taborda-Ocampo, G.; Valdez, J.C.; Bolling, B.W.; González-Correa, C.H. Polyphenol extracts from three Colombian passifloras (Passion fruits) prevent inflammation-induced barrier dysfunction of Caco-2 cells. Molecules 2019, 24, 4614. [Google Scholar] [CrossRef]
  47. Ghada, B.; Pereira, E.; Pinela, J.; Prieto, M.A.; Pereira, C.; Calhelha, R.C.; Stojković, D.; Sokóvić, M.; Zaghdoudi, K.; Barros, L.; et al. Recovery of anthocyanins from passion fruit epicarp for food colorants: Extraction process optimization and evaluation of bioactive properties. Molecules 2020, 25, 3203. [Google Scholar] [CrossRef]
  48. Kawasoe, H.; Wakamatsu, M.; Hamada, S.; Arata, Y.; Nagayoshi, K.; Uchida, R.; Yamashita, R.; Kishita, T.; Yamanouchi, H.; Minami, Y.; et al. Analysis of natural colourant extracted from the pericarp of passion fruit. LWT Food Sci. Technol. 2021, 136, 110412. [Google Scholar] [CrossRef]
  49. Oliveira, C.F.D.; Gurak, P.D.; Cladera-Olivera, F.; Marczak, L.D.F.; Karwe, M. Combined effect of high-pressure and conventional heating on pectin extraction from passion fruit peel. Food Bioprod. Process. 2016, 9, 1021–1030. [Google Scholar] [CrossRef]
  50. Vasco-Correa, J.; Zapata, A.D.Z. Enzymatic extraction of pectin from passion fruit peel (Passiflora edulis f. flavicarpa) at laboratory and bench scale. LWT Food Sci. Technol. 2017, 80, 280–285. [Google Scholar] [CrossRef]
  51. Pereira, D.T.V.; Méndez-Albiana, P.; Mendiola, J.A.; Villamiel, M.; Cifuentes, A.; Martínez, J.; Ibáñez, E. An eco-friendly extraction method to obtain pectin from passion fruit rinds (Passiflora edulis sp.) using subcritical water and pressurized natural deep eutectic solvents. Carbohydr. Polym. 2024, 326, 121578. [Google Scholar] [CrossRef] [PubMed]
  52. Yu, S.Y.; Yan, J.K.; Jin, M.Y.; Li, L.Q.; Yu, Y.H.; Xu, L. Preparation, physicochemical and functional characterization of pectic polysaccharides from fresh passion fruit peel by magnetic-induced electric field-assisted three-phase partitioning. Food Hydrocoll. 2024, 156, 110292. [Google Scholar] [CrossRef]
  53. Pereira, D.T.V.; Barrales, F.M.; Pereira, E.; Viganó, J.; Iglesias, A.H.; Reyes, F.G.R.; Martínez, J. Phenolic compounds from passion fruit rinds using ultrasound-assisted pressurized liquid extraction and nanofiltration. J. Food Eng. 2022, 325, 110977. [Google Scholar] [CrossRef]
  54. Chutia, H.; Mahanta, C.L. Green ultrasound and microwave extraction of carotenoids from passion fruit peel using vegetable oils as a solvent: Optimization, comparison, kinetics, and thermodynamic studies. Innov. Food Sci. Emerg. Technol. 2021, 67, 102547. [Google Scholar] [CrossRef]
  55. Herrera-Ramirez, J.; Meneses-Marente, N.; Díaz, M.P.T. Optimizing the extraction of anthocyanins from purple passion fruit peel using response surface methodology. J. Food Meas. Charact. 2020, 14, 1430–1441. [Google Scholar] [CrossRef]
  56. Wijaya, C.J.; Saputra, S.N.; Soetaredjo, F.E.; Putro, J.N.; Lin, C.X.; Kurniawan, A.; Ju, Y.H.; Ismadji, S. Cellulose nanocrystals from passion fruit peels waste as antibiotic drug carrier. Carbohydr. Polym. 2017, 175, 370–376. [Google Scholar] [CrossRef]
  57. Habtemariam, S. Modulation of reactive oxygen species in health and disease. Antioxidants 2019, 8, 513. [Google Scholar] [CrossRef]
  58. Malhotra, K.; Malik, A.; Almalki, W.H.; Sahebkar, A.; Kesharwani, P. Reactive oxygen species and its manipulation strategies in cancer treatment. Curr. Med. Chem. 2023, 32, 55–73. [Google Scholar] [CrossRef]
  59. Shahani, M.Y.; Bano, U.; Shahani, S.B.; Shaikh, P.; Memon, S.G.; Memon, S. Possible prevention of reactive oxygen species induced human trabecular meshwork cell damage by resveratrol and ascorbic acid. Prof. Med. J. 2019, 26, 1210–1215. [Google Scholar] [CrossRef]
  60. Outama, P.; Linh, N.V.; Xuan, C.L.; Wannaviji, S.; Tongsiri, S.; Chitmanat, C.; Montha, N.; Doan, H.V. Passionfruit (Passiflora edulis) peel powder stimulates the immune and antioxidant defense system in nile tilapia, Oreochromis niloticus, cultivated in a biofloc system. Fishes 2022, 7, 233. [Google Scholar] [CrossRef]
  61. Belmonte-Herrera, B.H.; Domínguez-Avila, J.A.; Wall-Medrano, A.; Ayala-Zavala, J.F.; Preciado-Saldaña, A.M.; Salazar-López, N.J.; López-Martínez, L.X.; Yahia, E.M.; Robles-Sánchez, R.M.; González-Aguilar, G.A. Lesser-consumed tropical fruits and their by-products: Phytochemical content and their antioxidant and anti-inflammatory potential. Nutrients 2022, 14, 3663. [Google Scholar] [CrossRef]
  62. Lubis, A.R.; Linh, N.V.; Srinual, O.; Fontana, C.M.; Tayyamath, K.; Wannavijit, S.; Ninyamasiri, P.; Uttarotai, T.; Tapingka, W.; Phimolsiripol, Y.; et al. Effects of passion fruit peel (Passiflora edulis) pectin and red yeast (Sporodiobolus pararoseus) cells on growth, immunity, intestinal morphology, gene expression, and gut microbiota in Nile tilapia (Oreochromis niloticus). Sci. Rep. 2024, 14, 73194. [Google Scholar] [CrossRef]
  63. Jiang, Q.; Charoensiddhi, S.; Xue, X.F.; Sun, B.Q.; Liu, Y.; El-Seedi, H.R.; Wang, K. A review on the gastrointestinal protective effects of tropical fruit polyphenols. Crit. Rev. Food Sci. Nutr. 2023, 63, 7130–7149. [Google Scholar] [CrossRef] [PubMed]
  64. Ju, Y.; Huang, L.L.; Luo, H.L.; Huang, Y.C.; Huang, X.Y.; Chen, G.; Gui, J.; Liu, Z.L.; Yang, L.; Liu, X.Z. Passion fruit peel and its zymolyte enhance gut function in Sanhuang broilers by improving antioxidation and short-chain fatty acids and decreasing inflammatory cytokines. Poult. Sci. 2023, 102, 102672. [Google Scholar] [CrossRef] [PubMed]
  65. Pimisa, R.; Prasongsuk, S.; Bankeeree, W.; Pongcharoen, P.; Arboleya, S.; Nogacka, A.M.; de los Reyes-Gavilán, C.G.; Hwanhlem, N.; Gueimonde, M. In vitro assessment of the impact of passion fruit peel—extracted pectin added with probiotic strains on the human intestinal microbiota and metabolic activity. LWT Food Sci. Technol. 2024, 213, 117082. [Google Scholar] [CrossRef]
  66. Silva, K.S.D.; Abboud, K.Y.; Schiebel, C.S.; de Oliveira, N.M.T.; Bueno, L.R.; Braga, L.L.V.D.M.; Silveira, B.C.D.; dos Santos, I.W.F.; Gomes, E.D.S.; Gois, M.B.; et al. Polysaccharides from Passion Fruit Peels: From an Agroindustrial By-Product to a Viable Option for 5-FU-Induced Intestinal Damage. Pharmaceuticals 2023, 16, 912. [Google Scholar] [CrossRef]
  67. Silveira, B.C.D.; Platner, F.D.S.; Rosa, L.B.D.; Silva, M.L.C.; Silva, K.S.D.; Oliveira, N.M.T.D.; Moffa, E.B.; Silva, K.F.; Lima-Neto, L.G.; Maria-Ferreira, D.; et al. Oral treatment with the pectin fibre obtained from yellow passion fruit peels worsens sepsis outcome in mice by affecting the intestinal barrier. Pharmaceuticals 2024, 17, 863. [Google Scholar] [CrossRef]
  68. Bueno, L.R.; Soley, B.D.S.; Abboud, K.Y.; França, I.W.; Silva, K.S.D.; Oliveira, N.M.T.D.; Barros, J.S.; Gois, M.B.; Cordeiro, L.M.C.; Maria-Ferreira, D. Protective effect of dietary polysaccharides from yellow passion fruit peel on DSS-induced colitis in mice. Oxid. Med. Cell. Longev. 2022, 2022, 6298662. [Google Scholar] [CrossRef]
  69. Xu, X.T.; Li, X.H.; Wei, X.S.; Duan, X.Q.; Wang, Y.H. Passion fruit peel fermentation extract and its active component kaempferol alleviate constipation and hemorrhoids in mice by downregulating ESR1 and PI3K/Akt pathways. J. Funct. Foods 2024, 115, 106112. [Google Scholar] [CrossRef]
  70. Sebastian, J.; Jose, S. Antidiabetic and antioxidant profile of three varieties of passion fruit. FoodSci Indian. J. Res. Food Sci. Nutr. 2018, 5, 16. [Google Scholar] [CrossRef]
  71. Nie, T.; Cooper, G.J.S. Mechanisms underlying the antidiabetic activities of polyphenolic compounds: A review. Front. Pharmacol. 2021, 12, 798329. [Google Scholar] [CrossRef] [PubMed]
  72. Vuolo, M.M.; Lima, G.C.; Batista, N.G.; Carazin, C.B.B.; Cintra, D.E.; Prado, M.A.; Júnior, M.R.M. Passion fruit peel intake decreases inflammatory response and reverts lipid peroxidation and adiposity in diet-induced obese rats. Nutr. Res. 2020, 76, 90–104. [Google Scholar] [CrossRef] [PubMed]
  73. Cabral, B.; Galdino, O.A.; Gomes, I.D.S.; Alves, J.S.F.; Marques, J.I.; de Souza, K.S.C.; da Silva, R.M.; Abreu, B.J.; Lopes, N.P.; Zucolotto, S.M.; et al. Bioactive extracts from the industrial byproduct of passion fruit promote better glycemic control in an adjuvant treatment with insulin and prevent kidney and heart damage in rats with type 1 Diabetes mellitus. J. Funct. Foods 2025, 124, 106638. [Google Scholar] [CrossRef]
  74. Balthar, R.D.O.; Maciel, A.P.O.A.; Ferreira, C.C.D. Benefícios da farinha do maracujá amarelo (Passiflora edulis F. Flavicarpa Deg.) no tratamento do Diabetes mellitus tipo 2: Uma revisão narrativa. Res. Soc. Dev. 2021, 10, e1091018404. [Google Scholar] [CrossRef]
  75. Hu, M.; Du, J.; Du, L.D.; Luo, Q.S.; Xiong, J.H. Anti-fatigue activity of purified anthocyanins prepared from purple passion fruit (P. edulis Sim) epicarp in mice. J. Funct. Foods 2020, 65, 103725. [Google Scholar] [CrossRef]
  76. Nerdy, N.; Ritarwan, K. Hepatoprotective activity and nephroprotective activity of peel extract from three varieties of the passion fruit (Passiflora sp.) in the albino rat. Open Access Maced. J. Med. Sci. 2019, 7, 3176–3181. [Google Scholar] [CrossRef]
  77. Nazliniwaty, N.; Harun, F.R.; Putra, E.D.L.; Nerdy, N. Antiaging activity of gel preparation containing three varieties of passion fruit peel ethanolic extract. Open Access Maced. J. Med. Sci. 2020, 8, 3462–3467. [Google Scholar] [CrossRef]
  78. Sie, Y.Y.; Chen, L.C.; Li, C.W.; Wang, C.C.; Li, C.J.; Liu, D.Z.; Lee, M.H.; Chen, L.G.; Hou, W.C. Extracts and scirpusin B from recycled seeds and rinds of passion fruits (Passiflora edulis var. Tainung No. 1) exhibit improved functions in scopolamine-induced impaired-memory ICR mice. Antioxidants 2023, 12, 2058. [Google Scholar] [CrossRef]
  79. Rizwana, H.; Otibi, F.A.; Al-malki, N. Chemical composition, FTIR studies and antibacterial activity of Passiflora edulis f. edulis (Fruit). J. Pure Appl. Microbiol. 2019, 13, 2247–2256. [Google Scholar] [CrossRef]
  80. Nguyen, T.T.T.; Tran, N.T.K.; Le, T.Q.; Nguyen, T.T.A.; Nguyen, L.T.M.; Tran, T.V. Passion fruit peel pectin/chitosan based antibacterial films incorporated with biosynthesized silver nanoparticles for wound healing application. Alexandria Eng. J. 2023, 69, 599–612. [Google Scholar] [CrossRef]
  81. U.S. Food and Drug Administration. Guidance for Industry Bioavailability and Bioequivalence, Studies Submitted in NDAs or INDs- General Considerations. 2024. Available online: https://www.fda.gov/media/88254/download (accessed on 8 May 2025).
  82. Nikou, T.; Sakavitsi, M.E.; Kalampokis, E.; Halabalaki, M. Metabolism and bioavailability of olive bioactive constituents based on in vitro, in vivo and human studies. Nutrients 2022, 14, 3773. [Google Scholar] [CrossRef] [PubMed]
  83. Cao, Q.Q.; Teng, J.W.; Wei, B.Y.; Huang, L.; Xia, N. Phenolic compounds, bioactivity, and bioaccessibility of ethanol extracts from passion fruit peel based on simulated gastrointestinal digestion. Food Chem. 2021, 356, 129682. [Google Scholar] [CrossRef] [PubMed]
  84. Nguyen, H.N.; Huynh, A.T.; Barcenas, M.; Le, T.M.; Vu, H.T.K.; Vu, N.T. Biochemical conversion of passion fruit waste into highly bioaccessible, stable, and selectively functional products. Waste Biomass Valor. 2025, 16, 1234–1245. [Google Scholar] [CrossRef]
  85. Souza, C.B.D.; Jonathan, M.; Saad, S.M.I.; Schols, H.A.; Venema, K. Characterization and in vitro digestibility of by-products from Brazilian food industry: Cassava bagasse, orange bagasse and passion fruit peel. Bioact. Carbohydr. Diet. Fibre 2018, 16, 35–44. [Google Scholar] [CrossRef]
  86. Macedo, M.C.C.; Correia, V.T.D.V.; Silva, V.D.M.; Pereira, D.T.V.; Augusti, R.; Melo, J.O.F.; Pires, C.V.; de Paula, A.C.C.F.F.; Fante, C.A. Development and characterization of yellow passion fruit peel flour (Passiflora edulis f. flavicarpa). Metabolites 2023, 13, 684. [Google Scholar] [CrossRef]
  87. Sampaio, R.F.; Lima, V.D.C.; Bungart, G.A.M.; Correia, L.D.B.; Tobal, T.M. Flour of winged-stem passion fruit peel: Nutritional composition, incorporation in cookies, and sensory acceptability. Braz. Arch. Biol. Technol. 2022, 65, e2200776. [Google Scholar] [CrossRef]
  88. Ning, X.; Wu, J.J.; Luo, Z.H.; Chen, Y.; Mo, Z.M.; Luo, R.H.; Bai, C.J.; Du, W.; Wang, L. Cookies fortified with purple passion fruit epicarp flour: Impact on physical properties, nutrition, in vitro starch digestibility, and antioxidant activity. Cereal Chem. 2021, 98, 1120–1133. [Google Scholar] [CrossRef]
  89. Garcia, M.V.; Milani, M.S.; Ries, E.F. Production optimization of passion fruit peel flour and its incorporation into dietary food. Food Sci. Technol. Int. 2020, 26, 108–120. [Google Scholar] [CrossRef]
  90. Nascimento, N.C.; de Medeiros, H.I.R.; Pereira, I.C.; de Oliveira, R.E.D.S.; de Medeiros, I.L.; Junior, F.C.D.M. Elaboração de biscoito com a farinha da casca do maracujá (Passiflora edulis). Res. Soc. Dev. 2020, 9, e9734333. [Google Scholar] [CrossRef]
  91. Nasution, H.; Harahap, H.; Iriany; Yustira, A.; Julianti, E.; Jaafar, M. Innovative edible food wraps from tilapia fish bone gelatin and passion fruit peel extract. Case Stud. Chem. Environ. Eng. 2024, 10, 100990. [Google Scholar] [CrossRef]
  92. Liu, Z.H.; Yang, T.X.; Chen, J.L.; Yang, C.Z.; Niu, J.Q.; Duan, X.; Ren, G.Y.; Li, L.L. The impact of passion fruit peel powder on the physicochemical, sensory properties, and antioxidant activity of goat milk yoghurt. Int. J. Food Sci. Technol. 2024, 59, 4567–4578. [Google Scholar] [CrossRef]
  93. Yu, Y.H.; Wu, L.B.; Li, L.Q.; Jin, M.Y.; Liu, X.Z.; Yu, X.Y.; Liu, F.Y.; Li, Y.T.; Li, L.; Yan, J.K. Effect of pectic polysaccharides from fresh passion fruit (Passiflora edulis f. flavicarpa L.) peel on physicochemical, texture and sensory properties of low-fat yoghurt. Food Chem. 2025, 479, 143801. [Google Scholar] [CrossRef]
  94. Silva, J.R.G.; Resende, E.D.D. Potential of the passion fruit mesocarp flour as a source of pectin and its application as thickener and gelling agent. Int. J. Food Sci. Technol. 2023, 58, 5678–5690. [Google Scholar] [CrossRef]
  95. Araujo, A.C.E.S.D.; Araujo, J.M.E.S.D.; Rezende, A.J.D.; Claro, P.S.; Araújo, R.L.D.O. Elaboração de geleia de goji berry, produzida de maneira artesanal, com adição de pectina da casca do maracujá. Res. Soc. Dev. 2020, 9, e963454. [Google Scholar] [CrossRef]
  96. Garrido, I.P.C.; Morais, S.K.O.; Coutinho, E.B.; de Oliveira, E.A.; Gouveia, D.S.; Vieira, P.P.F.; Mota, M.M.D.A.; Martins, J.J.A. Avaliação da estabilidade de geleia de maracujá adicionada da farinha da casca do maracujá e inulina por meio de indicadores físicos, físico-químicos e microbiológicos. Res. Soc. Dev. 2022, 11, e11111133902. [Google Scholar] [CrossRef]
  97. Pimisa, R.; Bankeeree, W.; Maneerat, S.; Pongcharoen, P.; Prasongsuk, S.; Hwanhlem, N. Extraction and characterization of pectin from passion fruit peel, and its application in synbiotic ice cream: A study from Phetchabun, Thailand. Fut. Foods 2024, 10, 100510. [Google Scholar] [CrossRef]
  98. Munhoz, D.R.; Moreira, F.K.V.; Bresolin, J.D.; Bernardo, M.P.; de Sousa, C.P.; Mattoso, L.H.C. Sustainable production and in vitro biodegradability of edible films from yellow passion fruit coproducts via continuous casting. ACS Sustain. Chem. Eng. 2018, 6, 15563–15575. [Google Scholar] [CrossRef]
  99. Nguyen, T.T.T.; Le, T.Q.; Nguyen, T.T.A.; Nguyen, L.T.M.; Nguyen, D.T.C.; Tran, T.V. Characterizations and antibacterial activities of passion fruit peel pectin/chitosan composite films incorporated Piper betle L. leaf extract for preservation of purple eggplants. Heliyon 2022, 8, e10096. [Google Scholar] [CrossRef]
  100. Tarigan, J.B.; Singh, K.; Sinuraya, J.S.; Supeno, M.; Sembiring, H.; Tarigan, K.; Rambe, S.M.; Karo-karo, J.A.; Sitepu, E.K. Waste passion fruit peel as a heterogeneous catalyst for room-temperature biodiesel production. ACS Omega 2022, 7, 7885–7894. [Google Scholar] [CrossRef]
  101. Barros, S.D.S.; Nobre, F.X.; Lobo, W.V.; Duvoisin, S.; Souza, C.A.S.D.; Herminio, V.L.D.Q.; Pereira, I.H.; Silva, E.P.; Iglauer, S.; Freitas, F.A.D. Eco-friendly biodiesel production using passion fruit peels and cupuaçu seeds: Catalyst development and process optimization. Biofuels, Bioprod. Bioref. 2024, 18, 567–580. [Google Scholar] [CrossRef]
  102. Silva, A.F.V.; Santos, L.A.; Valença, R.B.; Porto, T.S.; Sobrinho, M.A.D.M.; Gomes, G.J.C.; Jucá, J.F.T.; Santos, A.F.M.S. Cellulase production to obtain biogas from passion fruit (Passiflora edulis) peel waste hydrolysate. J. Environ. Chem. Eng. 2019, 7, 103510. [Google Scholar] [CrossRef]
  103. Betancur-Ancona, D.; Pérez-Navarrete, C.; Chel-Guerrero, L.; Sosa-Crespo, I.; Sandoval-Peraza, V. Functional, bioactive, and sensory properties of nutraceutical beverages enriched with passion fruit (Passiflora edulis) peel fiber. Food Chem. Adv. 2025, 7, 101005. [Google Scholar] [CrossRef]
Figure 1. Antioxidant mechanisms of polyphenols in PFP.
Figure 1. Antioxidant mechanisms of polyphenols in PFP.
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Figure 2. Mechanism of polyphenols’ effect on inflammation.
Figure 2. Mechanism of polyphenols’ effect on inflammation.
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Figure 3. Protective effect of polyphenols in PFP on intestinal health. P stands for polyphenols in the figure.
Figure 3. Protective effect of polyphenols in PFP on intestinal health. P stands for polyphenols in the figure.
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Figure 4. Methods for extracting nutrients from PFP, nutritional components, active ingredients, and their applications.
Figure 4. Methods for extracting nutrients from PFP, nutritional components, active ingredients, and their applications.
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Ba, L.; Luo, C.; Li, X.; Cao, S.; Luo, D. Research Progress on the Nutritional Components, Bioactivity, Health Effects, and Food Applications of Passion Fruit Peel (PFP). Foods 2025, 14, 3397. https://doi.org/10.3390/foods14193397

AMA Style

Ba L, Luo C, Li X, Cao S, Luo D. Research Progress on the Nutritional Components, Bioactivity, Health Effects, and Food Applications of Passion Fruit Peel (PFP). Foods. 2025; 14(19):3397. https://doi.org/10.3390/foods14193397

Chicago/Turabian Style

Ba, Liangjie, Chenglin Luo, Xue Li, Sen Cao, and Donglan Luo. 2025. "Research Progress on the Nutritional Components, Bioactivity, Health Effects, and Food Applications of Passion Fruit Peel (PFP)" Foods 14, no. 19: 3397. https://doi.org/10.3390/foods14193397

APA Style

Ba, L., Luo, C., Li, X., Cao, S., & Luo, D. (2025). Research Progress on the Nutritional Components, Bioactivity, Health Effects, and Food Applications of Passion Fruit Peel (PFP). Foods, 14(19), 3397. https://doi.org/10.3390/foods14193397

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