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Review

Recent Advances in the CRISPR/Cas-Based Nucleic Acid Biosensor for Food Analysis: A Review

by
Yanan Sun
,
Tianjian Wen
,
Ping Zhang
,
Minglian Wang
and
Yuancong Xu
*
College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, China
*
Author to whom correspondence should be addressed.
Foods 2024, 13(20), 3222; https://doi.org/10.3390/foods13203222
Submission received: 5 September 2024 / Revised: 30 September 2024 / Accepted: 9 October 2024 / Published: 10 October 2024
(This article belongs to the Special Issue Recent Advances in Biosensor Applications for Food Products)
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Abstract

Food safety is a major public health issue of global concern. In recent years, the CRISPR/Cas system has shown promise in the field of molecular detection. The system has been coupled with various nucleic acid amplification methods and combined with different signal output systems to develop a new generation of CRISPR/Cas-based nucleic acid biosensor technology. This review describes the design concept of the CRISPR/Cas-based nucleic acid biosensor and its application in food analysis. A detailed overview of different CRISPR/Cas systems, signal amplification methods, and signal output strategies is provided. CRISPR/Cas-based nucleic acid biosensors have the advantages of high sensitivity, strong specificity, and timeliness, achieving fast analysis of a variety of targets, including bacteria, toxins, metal ions, pesticides, veterinary drugs, and adulteration, promoting the development of rapid food safety detection technology. At the end, we also provide our outlook for the future development of CRISPR/Cas-based nucleic acid biosensors.
Keywords: CRISPR/Cas; biosensor; signal amplification; signal output; rapid detection; food analysis CRISPR/Cas; biosensor; signal amplification; signal output; rapid detection; food analysis

Share and Cite

MDPI and ACS Style

Sun, Y.; Wen, T.; Zhang, P.; Wang, M.; Xu, Y. Recent Advances in the CRISPR/Cas-Based Nucleic Acid Biosensor for Food Analysis: A Review. Foods 2024, 13, 3222. https://doi.org/10.3390/foods13203222

AMA Style

Sun Y, Wen T, Zhang P, Wang M, Xu Y. Recent Advances in the CRISPR/Cas-Based Nucleic Acid Biosensor for Food Analysis: A Review. Foods. 2024; 13(20):3222. https://doi.org/10.3390/foods13203222

Chicago/Turabian Style

Sun, Yanan, Tianjian Wen, Ping Zhang, Minglian Wang, and Yuancong Xu. 2024. "Recent Advances in the CRISPR/Cas-Based Nucleic Acid Biosensor for Food Analysis: A Review" Foods 13, no. 20: 3222. https://doi.org/10.3390/foods13203222

APA Style

Sun, Y., Wen, T., Zhang, P., Wang, M., & Xu, Y. (2024). Recent Advances in the CRISPR/Cas-Based Nucleic Acid Biosensor for Food Analysis: A Review. Foods, 13(20), 3222. https://doi.org/10.3390/foods13203222

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