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10.3390/foods12030627
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Article

Effects of Lactobacillus on the Differentiation of Intestinal Mucosa Immune Cells and the Composition of Gut Microbiota in Soybean-Sensitized Mice

by
Chunhua Yang
1,2,
Jierui Zhu
1,2,
Jing Bai
1,2,
Jie Zhang
3,
Zhihua Wu
1,2,
Xin Li
1,2,
Ping Tong
1,
Hongbing Chen
1,2 and
Anshu Yang
1,2,*
1
State Key Laboratory of Food Science and Technology, Nanchang University, Nanjing Dong Lu 235, Nanchang 330047, China
2
Sino-German Joint Research Institute, Nanchang University, Nanjing Dong Lu 235, Nanchang 330047, China
3
Experimental Animal Center, Jiangxi University of Chinese Medicine, 1688 Meiling Road, Nanchang 330004, China
*
Author to whom correspondence should be addressed.
Foods 2023, 12(3), 627; https://doi.org/10.3390/foods12030627
Submission received: 2 December 2022 / Revised: 11 January 2023 / Accepted: 31 January 2023 / Published: 1 February 2023
(This article belongs to the Special Issue Food Allergen Detection, Allergic Mechanism and Anti-allergy Research)
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Abstract

In the early stage of this study, three strains of Lactobacillus with anti-soybean allergy potential were screened: Lactobacillus acidophilus CICC 6081, Lactobacillus delbrueckii subsp. Bulgaricus CICC 6103 and Lactobacillus plantarum subsp. Plantarum CICC 20988. The aim of this study was to analyze the desensitization effect of three strains of Lactobacillus administered by gavage to soybean-allergic mice through the differentiation of immune cells in intestinal lymph nodes and the changes to gut microbiota. The results showed that the three strains of Lactobacillus could stimulate the proliferation of dendritic cells (DCs) and regulate the balance of Th1/Th2 differentiation in the MLNs and PPs of soybean-allergic mice. Furthermore, the Th17/Tregs cell-differentiation ratio in the MLNs of the Lactobacillus-treated mice was significantly lower than that of the allergic mice (p < 0.05). Compared to the control group, the Shannon, Sobs and Ace indexes of intestinal microbiota in the allergic mice were significantly increased (p < 0.05), and the proportion of Clostridiales was significantly higher (p < 0.05), which was reversed by Lactobacillus gavage. In conclusion, the three strains of Lactobacillus can inhibit the intestinal mucosal immune response and regulate gut microbiota balance in soybean-allergic mice.
Keywords: Lactobacillus; probiotics; intestinal mucosal immunity; immune-cell differentiation; gut microbiota; soybean allergy Lactobacillus; probiotics; intestinal mucosal immunity; immune-cell differentiation; gut microbiota; soybean allergy
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MDPI and ACS Style

Yang, C.; Zhu, J.; Bai, J.; Zhang, J.; Wu, Z.; Li, X.; Tong, P.; Chen, H.; Yang, A. Effects of Lactobacillus on the Differentiation of Intestinal Mucosa Immune Cells and the Composition of Gut Microbiota in Soybean-Sensitized Mice. Foods 2023, 12, 627. https://doi.org/10.3390/foods12030627

AMA Style

Yang C, Zhu J, Bai J, Zhang J, Wu Z, Li X, Tong P, Chen H, Yang A. Effects of Lactobacillus on the Differentiation of Intestinal Mucosa Immune Cells and the Composition of Gut Microbiota in Soybean-Sensitized Mice. Foods. 2023; 12(3):627. https://doi.org/10.3390/foods12030627

Chicago/Turabian Style

Yang, Chunhua, Jierui Zhu, Jing Bai, Jie Zhang, Zhihua Wu, Xin Li, Ping Tong, Hongbing Chen, and Anshu Yang. 2023. "Effects of Lactobacillus on the Differentiation of Intestinal Mucosa Immune Cells and the Composition of Gut Microbiota in Soybean-Sensitized Mice" Foods 12, no. 3: 627. https://doi.org/10.3390/foods12030627

APA Style

Yang, C., Zhu, J., Bai, J., Zhang, J., Wu, Z., Li, X., Tong, P., Chen, H., & Yang, A. (2023). Effects of Lactobacillus on the Differentiation of Intestinal Mucosa Immune Cells and the Composition of Gut Microbiota in Soybean-Sensitized Mice. Foods, 12(3), 627. https://doi.org/10.3390/foods12030627

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