Next Article in Journal
Amidine-Linked Closo-Dodecaborate–Silica Hybrids: Synthesis and Characterization
Next Article in Special Issue
A Recent Review of the Therapeutic Potential of Gold, Platinum, and Ruthenium Complexes Combined with Certain Organic Compounds
Previous Article in Journal
The Influence of Sintering Temperature on the Transport Properties of GdBa2Cu3O7 Superconductor Prepared from Nano-Powders via the Co-Precipitation Method
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Inorganics
Volume 14
Issue 1
10.3390/inorganics14010026
inorganics-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Synthesis, Characterization and Anticancer Activities of Zn2+, Ni2+, Co2+, and Cu2+ Complexes of 4-Benzopyranone-2-carboxylic Acid

by
Qianqian Kang
1,
Qasim Umar
2,
Wenjie Zhang
3,
Xianggao Meng
4,
Hao Yin
2,
Mei Luo
1,* and
Yanmin Zhang
3,*
1
College of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei 230009, China
2
Instruments Center for Physical Science, University of Science and Technology of China, Hefei 230022, China
3
Laboratory of Molecular Design and Drug Discovery, School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, China
4
College of Chemistry, Central China Normal University, Wuhan 430079, China
*
Authors to whom correspondence should be addressed.
Inorganics 2026, 14(1), 26; https://doi.org/10.3390/inorganics14010026
Submission received: 14 December 2025 / Revised: 8 January 2026 / Accepted: 9 January 2026 / Published: 12 January 2026
(This article belongs to the Special Issue Metal Complexes Containing Bioactive Ligands: Structure and Biological Evaluation, 2nd Edition)
Browse Figures
Review Reports Versions Notes

Abstract

Coordination complexes play a crucial role in modern research. 4-benzopyranone-2-carboxylic acid is a fascinating class of molecules with numerous applications, including the synthesis of pharmaceuticals and valuable chiral compounds. Antibacterial and tuberculostatic medicines, HIV protease inhibitors, intermediates in organic synthesis, and organic catalysis are only a few of the biological applications of chiral complexes. In this study, the synthesis of four metal complexes, C30H28N2NiO12 [Ni(bzpyr)2(py)2(H2O)2] (I), C30H24CoN2O10 [Co(bzpyr)2(py)2(H2O)2] (II), C20H20O13Zn [Zn(bzpyr)2(H2O)3] (III), and C30H22CuN2O9 [Cu(bzpyr)2(py)2(H2O)] (IV), is reported via direct reactions of 4-benzopyranone-2-carboxylic acid with metal salts and pyridine in anhydrous ethanol. Single-crystal X-ray diffraction analysis revealed that complexes I and II crystallize in the chiral space group P-1, whereas III and IV crystallize in the centrosymmetric space group P21/c. The structures of these complexes were further characterized by infrared spectroscopy, UV-Visible Diffuse Reflectance Spectroscopy, electrospray ionization mass spectrometry (ESI-MS), elemental analysis, nuclear magnetic resonance, electron paramagnetic resonance spectroscopy and single-crystal X-ray diffraction. In addition, the cytotoxic activities of complexes I–IV were evaluated against the human tumor cell lines K562, A549, HepG2, MDA-MB-231, and SW480, and molecular docking studies were conducted on the four complexes.
Keywords: chiral metallic complexes; 4-benzopyranone-2-carboxylic acid ligands; crystal structures; cytotoxic effects chiral metallic complexes; 4-benzopyranone-2-carboxylic acid ligands; crystal structures; cytotoxic effects
Graphical Abstract

Share and Cite

MDPI and ACS Style

Kang, Q.; Umar, Q.; Zhang, W.; Meng, X.; Yin, H.; Luo, M.; Zhang, Y. Synthesis, Characterization and Anticancer Activities of Zn2+, Ni2+, Co2+, and Cu2+ Complexes of 4-Benzopyranone-2-carboxylic Acid. Inorganics 2026, 14, 26. https://doi.org/10.3390/inorganics14010026

AMA Style

Kang Q, Umar Q, Zhang W, Meng X, Yin H, Luo M, Zhang Y. Synthesis, Characterization and Anticancer Activities of Zn2+, Ni2+, Co2+, and Cu2+ Complexes of 4-Benzopyranone-2-carboxylic Acid. Inorganics. 2026; 14(1):26. https://doi.org/10.3390/inorganics14010026

Chicago/Turabian Style

Kang, Qianqian, Qasim Umar, Wenjie Zhang, Xianggao Meng, Hao Yin, Mei Luo, and Yanmin Zhang. 2026. "Synthesis, Characterization and Anticancer Activities of Zn2+, Ni2+, Co2+, and Cu2+ Complexes of 4-Benzopyranone-2-carboxylic Acid" Inorganics 14, no. 1: 26. https://doi.org/10.3390/inorganics14010026

APA Style

Kang, Q., Umar, Q., Zhang, W., Meng, X., Yin, H., Luo, M., & Zhang, Y. (2026). Synthesis, Characterization and Anticancer Activities of Zn2+, Ni2+, Co2+, and Cu2+ Complexes of 4-Benzopyranone-2-carboxylic Acid. Inorganics, 14(1), 26. https://doi.org/10.3390/inorganics14010026

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop