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Review

Advances in Ultrafast Fiber Lasers for Multiphoton Microscopy in Neuroscience

Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
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Author to whom correspondence should be addressed.
Photonics 2023, 10(12), 1307; https://doi.org/10.3390/photonics10121307
Submission received: 7 September 2023 / Revised: 8 November 2023 / Accepted: 23 November 2023 / Published: 26 November 2023
(This article belongs to the Special Issue Recent Advances in Multiphoton Microscopy)

Abstract

Multiphoton microscopy (MPM) has emerged as a vital tool in neuroscience, enabling deeper imaging with a broader field of view, as well as faster and sub-cellular resolution. Recent innovations in ultrafast fiber laser technology have revolutionized MPM applications in living brains, offering advantages like cost-effectiveness and user-friendliness. In this review, we explore the progress in ultrafast fiber laser technology, focusing on its integration into MPM for neuroscience research. We also examine the utility of femtosecond fiber lasers in fluorescence and label-free two- and three-photon microscopy applications within the field. Furthermore, we delve into future possibilities, including next-generation fiber laser designs, novel laser characteristics, and their potential for achieving high spatial and temporal resolution imaging. We also discuss the integration of fiber lasers with implanted microscopes, opening doors for clinical and fundamental neuroscience investigations.
Keywords: ultrafast fiber lasers; multiphoton microscopy; neuroscience; multi-wavelength; saturable absorbers; fiber amplifier ultrafast fiber lasers; multiphoton microscopy; neuroscience; multi-wavelength; saturable absorbers; fiber amplifier

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MDPI and ACS Style

Srinivasan, T.; Yildirim, M. Advances in Ultrafast Fiber Lasers for Multiphoton Microscopy in Neuroscience. Photonics 2023, 10, 1307. https://doi.org/10.3390/photonics10121307

AMA Style

Srinivasan T, Yildirim M. Advances in Ultrafast Fiber Lasers for Multiphoton Microscopy in Neuroscience. Photonics. 2023; 10(12):1307. https://doi.org/10.3390/photonics10121307

Chicago/Turabian Style

Srinivasan, Thulasi, and Murat Yildirim. 2023. "Advances in Ultrafast Fiber Lasers for Multiphoton Microscopy in Neuroscience" Photonics 10, no. 12: 1307. https://doi.org/10.3390/photonics10121307

APA Style

Srinivasan, T., & Yildirim, M. (2023). Advances in Ultrafast Fiber Lasers for Multiphoton Microscopy in Neuroscience. Photonics, 10(12), 1307. https://doi.org/10.3390/photonics10121307

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