Applying a Hydrophilic Modified Hollow Fiber Membrane to Reduce Fouling in Artificial Lungs
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Fabrication of Hollow Fiber Membrane (HFMs)
2.3. Preparation of the Chamber for Gas Exchange Experiments
3. Results
4. Discussions
5. Conclusions
Author Contributions
Funding
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
- Ware, L.B.; Matthay, M.A. The acute respiratory distress syndrome. N. Engl. J. Med. 2000, 342, 1334–1349. [Google Scholar] [CrossRef]
- Cook, K.E.; Makarewicz, A.J.; Backer, C.L.; Mockros, L.F.; Przybylo, H.J.; Crawford, S.E.; Mavroudis, C. Testing of an intrathoracic artificial lung in a pig model. ASAIO J. 1996, 42, M604–M608. [Google Scholar] [CrossRef]
- Lynch, W.R.; Montoya, J.P.; Brant, D.O.; Schreiner, R.J.; Iannettoni, M.D.; Bartlett, R.H. Hemodynamic effect of a low-resistance artificial lung in series with the native lungs of sheep. Ann. Thorac. Surg. 2000, 69, 351–356. [Google Scholar] [CrossRef]
- Beckley, P.D.; Holt, D.W.; Tallman, R.D., Jr. Oxygenators for extracorporeal circulation. In Cardiopulmonary Bypass; Springer: New York, NY, USA, 1995; pp. 199–219. [Google Scholar]
- Iwahashi, H.; Yuri, K.; Nosé, Y. Development of the oxygenator: Past, present, and future. J. Artif. Organs 2004, 7, 111–120. [Google Scholar] [CrossRef]
- Park, J.Y.; Acar, M.H.; Akthakul, A.; Kuhlman, W.; Mayes, A.M. Polysulfone-graft-poly (ethylene glycol) graft copolymers for surface modification of polysulfone membranes. Biomaterials 2006, 27, 856–865. [Google Scholar] [CrossRef]
- Yang, M.C.; Lin, W.C. Protein adsorption and platelet adhesion of polysulfone membrane immobilized with chitosan and heparin conjugate. Polym. Adv. Technol. 2003, 14, 103–113. [Google Scholar] [CrossRef]
- Golob, J.F.; Federspiel, W.J.; Merrill, T.L.; Frankowski, B.J.; Litwak, K.; Russian, H.; Hattler, B.G. Acute in vivo testing of an intravascular respiratory support catheter. ASAIO J. 2001, 47, 432–437. [Google Scholar] [CrossRef] [PubMed]
- Ye, S.H.; Arazawa, D.T.; Zhu, Y.; Shankarraman, V.; Malkin, A.D.; Kimmel, J.D.; Wagner, W.R. Hollow fiber membrane modification with functional zwitterionic macromolecules for improved thromboresistance in artificial lungs. Langmuir 2015, 31, 2463–2471. [Google Scholar] [CrossRef] [Green Version]
- Hattler, B.G.; Lund, L.W.; Golob, J.; Russian, H.; Lann, M.F.; Merrill, T.L.; Federspiel, W.J. A respiratory gas exchange catheter: In vitro and in vivo tests in large animals. J. Thorac. Cardiovasc. Surg. 2002, 124, 520–530. [Google Scholar] [CrossRef] [Green Version]
- Oh, H.I.; Ye, S.H.; Johnson, C.A., Jr.; Woolley, J.R.; Federspiel, W.J.; Wagner, W.R. Hemocompatibility assessment of carbonic anhydrase modified hollow fiber membranes for artificial lungs. Artif. Organs 2010, 34, 439–442. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Lin, C.C.; Yang, M.C. Urea permeation and hydrolysis through hollow fiber dialyzer immobilized with urease: Storage and operation properties. Biomaterials 2003, 24, 1989–1994. [Google Scholar] [CrossRef]
- Arazawa, D.T.; Oh, H.I.; Ye, S.H.; Johnson, C.A.; Woolley, J.R.; Wagner, W.R.; Federspiel, W.J. Immobilized carbonic anhydrase on hollow fiber membranes accelerates CO2 removal from blood. J. Membr. Sci. 2012, 403, 25–31. [Google Scholar] [CrossRef] [Green Version]
- Jiang, J.; Zhu, L.; Zhu, L.; Zhu, B.; Xu, Y. Surface characteristics of a self-polymerized dopamine coating deposited on hydrophobic polymer films. Langmuir 2011, 27, 14180–14187. [Google Scholar] [CrossRef]
- Shao, L.; Wang, Z.X.; Zhang, Y.L.; Jiang, Z.X.; Liu, Y.Y. A facile strategy to enhance PVDF ultrafiltration membrane performance via self-polymerized polydopamine followed by hydrolysis of ammonium fluotitanate. J. Membr. Sci. 2014, 461, 10–21. [Google Scholar] [CrossRef]
- Li, F.; Meng, J.; Ye, J.; Yang, B.; Tian, Q.; Deng, C. Surface modification of PES ultrafiltration membrane by polydopamine coating and poly (ethylene glycol) grafting: Morphology, stability, and anti-fouling. Desalination 2014, 344, 422–430. [Google Scholar] [CrossRef]
- Statz, A.R.; Meagher, R.J.; Barron, A.E.; Messersmith, P.B. New peptidomimetic polymers for antifouling surfaces. J. Am. Chem. Soc. 2005, 127, 7972–7973. [Google Scholar] [CrossRef]
- Statz, A.R.; Barron, A.E.; Messersmith, P.B. Protein, cell and bacterial fouling resistance of polypeptoid-modified surfaces: Effect of side-chain chemistry. Soft Matter 2008, 4, 131–139. [Google Scholar] [CrossRef]
- Alluri, P.G.; Reddy, M.M.; Bachhawat-Sikder, K.; Olivos, H.J.; Kodadek, T. Isolation of protein ligands from large peptoid libraries. J. Am. Chem. Soc. 2003, 125, 13995–14004. [Google Scholar] [CrossRef]
- Reed, L. Hollow Fibers for Artificial Lung Applications. Bachelor’s Thesis, University of Arkansas, Fayetteville, AR, USA, December 2016. [Google Scholar]
- Deshmukh, S.P.; Li, K. Effect of ethanol composition in water coagulation bath on morphology of PVDF hollow fibre membranes. J. Membr. Sci. 1998, 150, 75–85. [Google Scholar] [CrossRef]
- Chipley, J.R. 2 Sodium Benzoate and Benzoic Acid. In Antimicrobials in Food; CRC Press: Boca Raton, FL, USA, 2005; pp. 41–88. [Google Scholar] [CrossRef]
- Eash, H.J.; Jones, H.M.; Hattler, B.G.; Federspiel, W.J. Evaluation of plasma resistant hollow fiber membranes for artificial lungs. ASAIO J. 2004, 50, 491–497. [Google Scholar] [CrossRef] [Green Version]
- Asgharpour, M.; Mehrnia, M.R.; Mostoufi, N. Effect of surface contaminants on oxygen transfer in bubble column reactors. Biochem. Eng. J. 2010, 49, 351–360. [Google Scholar] [CrossRef]
- Mahmoudi, N.; Reed, L.; Moix, A.; Alshammari, N.; Hestekin, J.; Servoss, S.L. PEG-mimetic peptoid reduces protein fouling of polysulfone hollow fibers. Colloids Surf. B Biointerfaces 2017, 149, 23–29. [Google Scholar] [CrossRef]
- Li, X.-L.; Zhu, L.-P.; Jiang, J.-H.; Yi, Z.; Zhu, B.-K.; Xu, Y.-Y. Hydrophilic nanofiltration membranes with self-polymerized and strongly-adhered polydopamine as separating layer. Chin. J. Polym. Sci. 2011, 30, 152–163. [Google Scholar] [CrossRef]
- Mahmoudi, N.; Roberts, J.; Harrison, G.; Alshammari, N.; Hestekin, J.; Servoss, S.L. Low Fouling, Peptoid-Coated Polysulfone Hollow Fiber Membranes—The Effect of Grafting Density and Number of Side Chains. Appl. Biochem. Biotechnol. 2020, 191, 824–837. [Google Scholar] [CrossRef]
- He, T.; He, J.; Wang, Z.; Cui, Z. Modification strategies to improve the membrane hemocompatibility in extracorporeal membrane oxygenator (ECMO). Adv. Compos. Hybrid Mater. 2021, 1–18. [Google Scholar] [CrossRef]
- Rana, D.; Matsuura, T. Surafce modifications for antifouling membranes. Chem. Rev. 2010, 110, 2448–2471. [Google Scholar] [CrossRef]
Time (min.) | PSU-BSA 35 mg/mL | PSU-PDA-BSA 35 mg/mL | PSU-PDA-NMEG5-BSA 35 mg/mL |
---|---|---|---|
30 | 0.029 ± 0.016 | 0.012 ± 0.009 | 0.0166 ± 0.005 |
60 | 0.026 ± 0.017 | 0.013 ± 0.010 | 0.015 ± 0.004 |
90 | 0.019 ± 0.010 | 0.015 ± 0.012 | 0.018 ± 0.006 |
120 | 0.011 ± 0.004 | 0.015 ± 0.011 | 0.019 ± 0.007 |
150 | 0.007 ± 0.0102 | 0.014 ± 0.008 | 0.028 ± 0.02 |
180 | 0 | 0.019 ± 0.015 | 0.04 ± 0.005 |
210 | 0 | 0.013 ± 0.023 | 0.023 ± 0.005 |
240 | 0 | 0.006 ± 0.002 | 0.015 ± 0.014 |
270 | 0 | 0.001 ± 0.001 | 0.010 ± 0.011 |
300 | 0 | 0.002 ± 0.006 | 0.010 ± 0.014 |
330 | 0 | 0.001 ± 0.002 | 0.018 ± 0.012 |
360 | 0 | 0 | 0.014 ± 0.008 |
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. |
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Share and Cite
Alshammari, N.; Alazmi, M.; Veettil, V.N. Applying a Hydrophilic Modified Hollow Fiber Membrane to Reduce Fouling in Artificial Lungs. Separations 2021, 8, 113. https://doi.org/10.3390/separations8080113
Alshammari N, Alazmi M, Veettil VN. Applying a Hydrophilic Modified Hollow Fiber Membrane to Reduce Fouling in Artificial Lungs. Separations. 2021; 8(8):113. https://doi.org/10.3390/separations8080113
Chicago/Turabian StyleAlshammari, Nawaf, Meshari Alazmi, and Vajid Nettoor Veettil. 2021. "Applying a Hydrophilic Modified Hollow Fiber Membrane to Reduce Fouling in Artificial Lungs" Separations 8, no. 8: 113. https://doi.org/10.3390/separations8080113