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Metal-Organic Frameworks in Green Analytical Chemistry

Department of Chemistry, Analytical Division, University of La Laguna, 38206 Tenerife, Spain
X-ray and Molecular Materials Lab (MATMOL), Physics Department, University of La Laguna, 38206 Tenerife, Spain
University Institute of Tropical Diseases and Public Health, University of La Laguna (ULL), La Laguna, 38206 Tenerife, Spain
Author to whom correspondence should be addressed.
These authors contribute equally to this work.
Separations 2019, 6(3), 33;
Received: 31 May 2019 / Revised: 14 June 2019 / Accepted: 21 June 2019 / Published: 27 June 2019
(This article belongs to the Special Issue Development of Alternative Green Sample Preparation Techniques)
PDF [3923 KB, uploaded 28 June 2019]


Metal-organic frameworks (MOFs) are porous hybrid materials composed of metal ions and organic linkers, characterized by their crystallinity and by the highest known surface areas. MOFs structures present accessible cages, tunnels and modifiable pores, together with adequate mechanical and thermal stability. Their outstanding properties have led to their recognition as revolutionary materials in recent years. Analytical chemistry has also benefited from the potential of MOF applications. MOFs succeed as sorbent materials in extraction and microextraction procedures, as sensors, and as stationary or pseudo-stationary phases in chromatographic systems. To date, around 100 different MOFs form part of those analytical applications. This review intends to give an overview on the use of MOFs in analytical chemistry in recent years (2017–2019) within the framework of green analytical chemistry requirements, with a particular emphasis on possible toxicity issues of neat MOFs and trends to ensure green approaches in their preparation. View Full-Text
Keywords: metal-organic frameworks; analytical chemistry; sorbent materials; stationary phases; sensors; sample preparation; green considerations metal-organic frameworks; analytical chemistry; sorbent materials; stationary phases; sensors; sample preparation; green considerations

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Rocío-Bautista, P.; Taima-Mancera, I.; Pasán, J.; Pino, V. Metal-Organic Frameworks in Green Analytical Chemistry. Separations 2019, 6, 33.

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