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The Development of Silica Hydride Stationary Phases for High-Performance Liquid Chromatography from Conception to Commercialization

Department of Chemistry, San Jose State University, San Jose, CA 95192, USA
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Separations 2019, 6(2), 27; https://doi.org/10.3390/separations6020027
Received: 24 February 2019 / Revised: 25 March 2019 / Accepted: 24 April 2019 / Published: 21 May 2019
The development of a stationary phase material for high-performance liquid chromatography based on a surface of silica hydride as opposed to silanols on ordinary silica is discussed including synthetic approaches, characterization, and applications. There are several synthetic approaches available to create a silica hydride surface. Modification of the Si–H moiety on the silica surface can be accomplished through the use of a hydrosilation reaction. Both the intermediate silica hydride and the material modified with an organic moiety can be characterized by a number of spectroscopic as well as a variety of other methods. Further insights into the retention mechanism are provided through chromatographic measurements. The ultimate utility of any chromatographic stationary phase material is determined by its success in solving challenging analytical problems. A broad range of applications is reviewed to illustrate the versatility and usefulness of silica hydride-based stationary phases. View Full-Text
Keywords: hydride surface; silicon-carbon bond; aqueous normal phase; retention mechanism hydride surface; silicon-carbon bond; aqueous normal phase; retention mechanism
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Matyska, M.; Pesek, J. The Development of Silica Hydride Stationary Phases for High-Performance Liquid Chromatography from Conception to Commercialization. Separations 2019, 6, 27.

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