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Separations 2018, 5(2), 25; https://doi.org/10.3390/separations5020025

Silk Fibroin Nanoparticles for Drug Delivery: Effect of Bovine Serum Albumin and Magnetic Nanoparticles Addition on Drug Encapsulation and Release

1
Division of Analytical Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
2
Department of Physics, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
3
Department of Food Technology, ATEI of Thessaloniki, P.O. BOX 141, 57400 Thessaloniki, Greece
4
Division of Chemical Technology, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
*
Author to whom correspondence should be addressed.
Received: 4 February 2018 / Revised: 19 March 2018 / Accepted: 9 April 2018 / Published: 23 April 2018
(This article belongs to the Special Issue Research as Development Perspective)
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Abstract

Silk fibroin nanoparticles were prepared in the present study based on phase separation between silk fibroin and polyvinyl alcohol. The drug encapsulation efficiency of the prepared nanoparticles was examined at a range of concentrations from 10 ppm to 500 ppm for pramipexole, curcumin, and propranolol hydrochloride. Silk fibroin nanoparticles encapsulated with propranolol presented the highest drug release profile. In order to improve the drug encapsulation efficiency and drug release performance, a modification of silk fibroin nanoparticles with bovine serum albumin and magnetic nanoparticles was tried. The modification was found to improve the drug encapsulation and release of the modified nanoparticles. Bovine-serum-modified nanoparticles presented the best improvement. View Full-Text
Keywords: silk fibroin; drug delivery; magnetic silk fibroin; bovine serum albumin silk fibroin; drug delivery; magnetic silk fibroin; bovine serum albumin
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Gianak, O.; Pavlidou, E.; Sarafidis, C.; Karageorgiou, V.; Deliyanni, E. Silk Fibroin Nanoparticles for Drug Delivery: Effect of Bovine Serum Albumin and Magnetic Nanoparticles Addition on Drug Encapsulation and Release. Separations 2018, 5, 25.

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