Next Article in Journal
Determination of Pterostilbene in Pharmaceutical Products Using a New HPLC Method and Its Application to Solubility and Stability Samples
Previous Article in Journal
Characterization of the Aroma Profile of Food Smoke at Controllable Pyrolysis Temperatures
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Separations
Volume 10
Issue 3
10.3390/separations10030177
separations-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

An Overview of Herbal Nutraceuticals, Their Extraction, Formulation, Therapeutic Effects and Potential Toxicity

by
Vaishnavi Bommakanti
1,
Amruthamol Puthenparambil Ajikumar
1,
Chelssa Maria Sivi
1,
Geethika Prakash
1,
Anjaly Shanker Mundanat
1,
Faraz Ahmad
2,
Shafiul Haque
3,4,5,
Miguel Angel Prieto
6,* and
Sandeep Singh Rana
1,*
1
Department of Biosciences, School of Bio Science and Technology (SBST), Vellore Institute of Technology, Vellore 632014, India
2
Department of Biotechnology, School of Bio Science and Technology (SBST), Vellore Institute of Technology, Vellore 632014, India
3
Research and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University, Jazan 45142, Saudi Arabia
4
Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Beirut P.O. Box 13-5053, Lebanon
5
Centre of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman P.O. Box 346, United Arab Emirates
6
Nutrition and Bromatology Group, Analytical and Food Chemistry Department, Faculty of Food Science and Technology, University of Vigo, Ourense Campus, E-32004 Ourense, Spain
*
Authors to whom correspondence should be addressed.
Separations 2023, 10(3), 177; https://doi.org/10.3390/separations10030177
Submission received: 28 December 2022 / Revised: 24 February 2023 / Accepted: 26 February 2023 / Published: 6 March 2023
(This article belongs to the Section Analysis of Food and Beverages)
Browse Figures
Versions Notes

Abstract

Herbal nutraceuticals are foods derived from plants and/or their derivatives, such as oils, roots, seeds, berries, or flowers, that support wellness and combat acute and chronic ailments induced by unhealthful dietary habits. The current review enlists various traditional as well as unexplored herbs including angelica, burnet, caraway, laurel, parsley, yarrow, and zedoary, which are rich sources of bioactive components, such as aloesin, angelicin, trans-anethole, and cholesteric-7-en-3β-ol. The review further compares some of the extraction and purification techniques, namely, Soxhlet extraction, ultrasound assisted extraction, microwave assisted extraction, supercritical fluid extraction, accelerated solvent extraction, hydro-distillation extraction, ultra-high-pressure extraction, enzyme assisted extraction, pulsed electric field extraction, bio affinity chromatography, cell membrane chromatography, and ligand fishing. Herbal nutraceuticals can be purchased in varied formulations, such as capsules, pills, powders, liquids, and gels. Some of the formulations currently available on the market are discussed here. Further, the significance of herbal nutraceuticals in prevention and cure of diseases, such as diabetes, obesity, dementia, hypertension, and hypercholesterolemia; and as immunomodulators and antimicrobial agents has been discussed. Noteworthy, the inappropriate use of these herbal nutraceuticals can lead to hepatotoxicity, pulmonary toxicity, cytotoxicity, carcinogenicity, nephrotoxicity, hematotoxicity, and cardiac toxicity. Hence, this review concludes with a discussion of various regulatory aspects undertaken by the government agencies in order to minimize the adverse effects associated with herbal nutraceuticals.
Keywords: nutraceuticals; herbs; bioactive-compounds; extraction; purification; identification; formulation; market; therapeutic-effect; adverse-effect; regulations nutraceuticals; herbs; bioactive-compounds; extraction; purification; identification; formulation; market; therapeutic-effect; adverse-effect; regulations
Graphical Abstract

Share and Cite

MDPI and ACS Style

Bommakanti, V.; Puthenparambil Ajikumar, A.; Sivi, C.M.; Prakash, G.; Mundanat, A.S.; Ahmad, F.; Haque, S.; Prieto, M.A.; Rana, S.S. An Overview of Herbal Nutraceuticals, Their Extraction, Formulation, Therapeutic Effects and Potential Toxicity. Separations 2023, 10, 177. https://doi.org/10.3390/separations10030177

AMA Style

Bommakanti V, Puthenparambil Ajikumar A, Sivi CM, Prakash G, Mundanat AS, Ahmad F, Haque S, Prieto MA, Rana SS. An Overview of Herbal Nutraceuticals, Their Extraction, Formulation, Therapeutic Effects and Potential Toxicity. Separations. 2023; 10(3):177. https://doi.org/10.3390/separations10030177

Chicago/Turabian Style

Bommakanti, Vaishnavi, Amruthamol Puthenparambil Ajikumar, Chelssa Maria Sivi, Geethika Prakash, Anjaly Shanker Mundanat, Faraz Ahmad, Shafiul Haque, Miguel Angel Prieto, and Sandeep Singh Rana. 2023. "An Overview of Herbal Nutraceuticals, Their Extraction, Formulation, Therapeutic Effects and Potential Toxicity" Separations 10, no. 3: 177. https://doi.org/10.3390/separations10030177

APA Style

Bommakanti, V., Puthenparambil Ajikumar, A., Sivi, C. M., Prakash, G., Mundanat, A. S., Ahmad, F., Haque, S., Prieto, M. A., & Rana, S. S. (2023). An Overview of Herbal Nutraceuticals, Their Extraction, Formulation, Therapeutic Effects and Potential Toxicity. Separations, 10(3), 177. https://doi.org/10.3390/separations10030177

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop