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Open AccessArticle

Antiproliferative, Antimicrobial, and Antifungal Activities of Polyphenol Extracts from Ferocactus Species

1
Plant Production Department, College of Food and Agriculture Sciences, King Saud University, Riyadh 11451, Saudi Arabia
2
Floriculture, Ornamental Horticulture, and Garden Design Department, Faculty of Agriculture (El-Shatby), Alexandria University, Alexandria 21526, Egypt
3
Department of Pharmaceutical Botany, Medical College, Jagiellonian University, ul. Medyczna 9, 30-688 Kraków, Poland
4
Botanical Gardens Research Department, Horticultural Research Institute (ARC), Alexandria 00203, Egypt
*
Author to whom correspondence should be addressed.
Processes 2020, 8(2), 138; https://doi.org/10.3390/pr8020138 (registering DOI)
Received: 16 December 2019 / Revised: 15 January 2020 / Accepted: 19 January 2020 / Published: 21 January 2020
(This article belongs to the Special Issue Extraction Optimization Processes of Antioxidants)
Polyphenols, obtained from natural resources, may possess important pharmacological effects. The polyphenolic profiles of the stem extracts of six Ferocactus species (sp.): F. gracilis, F. pottsii, F. herrerae, F. horridus, F. glaucescens, and F. emoryi, were measured using high-performance liquid chromatography (HPLC) with diode-array detection (DAD). Additionally, anticancer, antibacterial, and antifungal activities were examined. Results showed the presence of high to moderate amounts of polyphenols in the extracts (phenolic acids: Protocatechuic acid, 3,4-dihydroxyphenylacetic acid, caffeic acid, and vanillic acid; flavonoids: Rutoside and quercitrin). The highest amounts of 3,4-dihydroxyphenylacetic acid were found in F. glaucescens ((132.09 mg 100 g−1 dry weight (DW)), F. pottsii (75.71 mg 100 g−1 DW), and F. emoryi (69.14 mg 100 g−1 DW) while rutoside content was highest in F. glaucescens (107.66 mg 100 g−1 DW). Maximum antiproliferative activities were observed against HeLa and Jurkat cancer cells, with F. glaucescens, F. emoryi, and F. pottsii showing the highest anticancer activity. Most bacteria were sensitive to Ferocactus sp. stem extracts. Escherichia coli and Staphylococcus aureus were the most sensitive. Excellent antifungal effects were observed against Aspergillus ochraceus and A. niger. However, Penicillium funiculosum, P. ochrochloron, and Candida albicans were relatively resistant. This is the first study reporting novel sources of polyphenols in Ferocactus sp. with anticancer and antimicrobial activities. View Full-Text
Keywords: Ferocactus; stem extract; polyphenols; anticancer; antibacterial; antifungal; cytotoxicity Ferocactus; stem extract; polyphenols; anticancer; antibacterial; antifungal; cytotoxicity
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O. Elansary, H.; Szopa, A.; Klimek-Szczykutowicz, M.; Ekiert, H.; Barakat, A.A.; A. Al-Mana, F. Antiproliferative, Antimicrobial, and Antifungal Activities of Polyphenol Extracts from Ferocactus Species. Processes 2020, 8, 138.

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