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Volume 9
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10.3390/children9020276
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Article

Association of Weight Changes by Three Days after Birth and Mortality and/or Severe Neurological Injury in Preterm Infants < 29 Weeks Gestational Age: A Multicenter Cohort Study

by
Carlos Zozaya
1,
Khalid Aziz
2,
Nalini Singhal
3,
Xiang Y. Ye
4,
Christine Drolet
5,
Julie Emberley
6,
Kyong-Soon Lee
7,
Vibhuti S. Shah
1,* and
on behalf of the Canadian Neonatal Network (CNN) Investigators
†
1
Department of Paediatrics, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada
2
Department of Pediatrics, University of Alberta, Edmonton, AB T6G 1C9, Canada
3
Department of Pediatrics, University of Calgary, Calgary, AB T2N 1N4, Canada
4
Maternal-Infant Care (MiCare) Research Centre, Mount Sinai Hospital, Toronto, ON M5G 1X6, Canada
5
Centre Mère-Enfant Soleil, Centre Hospitalier Universitaire de Québec, Université Laval, Quebec City, QC G1V 4G2, Canada
6
Department of Pediatrics, Janeway Children’s Health and Rehabilitation Center, Memorial University of Newfoundland, St. John’s, NL A1B 3V6, Canada
7
Division of Neonatology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada
*
Author to whom correspondence should be addressed.
†
The Canadian Neonatal Network (CNN) Investigators are mentioned in the Acknowledgments.
Children 2022, 9(2), 276; https://doi.org/10.3390/children9020276
Submission received: 18 January 2022 / Revised: 13 February 2022 / Accepted: 13 February 2022 / Published: 17 February 2022
(This article belongs to the Special Issue Health Care in Premature Infants)
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Abstract

Objective: This study aimed to determine the range of weight loss, at 3 days postnatal age, associated with the lowest risk of mortality/short-term morbidity in preterm infants <29 weeks gestational age (GA). Study design: This multicenter retrospective cohort study employed data from the Canadian Neonatal Network database. The primary outcome was a composite of mortality and/or severe neurological injury. Multivariable quadratic and linear regression models which adjusted for potential confounders were built. Results: A total of 9275 preterm infants (median GA 26, IQR 25, 28 weeks) were included. The optimal weight change range at day three, after adjustment for potential confounders for the primary outcomes, was −15 to −8.9%. Conclusions: There is a ‘U’-shaped relationship between weight change from birth to day three and mortality and/or severe neurological injury. Interventional studies, which target weight loss within the range found in this study and evaluate the impact on neonatal outcomes, are needed to corroborate our findings.
Keywords: preterm-infant; weight; mortality; neurological injury preterm-infant; weight; mortality; neurological injury

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MDPI and ACS Style

Zozaya, C.; Aziz, K.; Singhal, N.; Ye, X.Y.; Drolet, C.; Emberley, J.; Lee, K.-S.; Shah, V.S.; on behalf of the Canadian Neonatal Network (CNN) Investigators. Association of Weight Changes by Three Days after Birth and Mortality and/or Severe Neurological Injury in Preterm Infants < 29 Weeks Gestational Age: A Multicenter Cohort Study. Children 2022, 9, 276. https://doi.org/10.3390/children9020276

AMA Style

Zozaya C, Aziz K, Singhal N, Ye XY, Drolet C, Emberley J, Lee K-S, Shah VS, on behalf of the Canadian Neonatal Network (CNN) Investigators. Association of Weight Changes by Three Days after Birth and Mortality and/or Severe Neurological Injury in Preterm Infants < 29 Weeks Gestational Age: A Multicenter Cohort Study. Children. 2022; 9(2):276. https://doi.org/10.3390/children9020276

Chicago/Turabian Style

Zozaya, Carlos, Khalid Aziz, Nalini Singhal, Xiang Y. Ye, Christine Drolet, Julie Emberley, Kyong-Soon Lee, Vibhuti S. Shah, and on behalf of the Canadian Neonatal Network (CNN) Investigators. 2022. "Association of Weight Changes by Three Days after Birth and Mortality and/or Severe Neurological Injury in Preterm Infants < 29 Weeks Gestational Age: A Multicenter Cohort Study" Children 9, no. 2: 276. https://doi.org/10.3390/children9020276

APA Style

Zozaya, C., Aziz, K., Singhal, N., Ye, X. Y., Drolet, C., Emberley, J., Lee, K.-S., Shah, V. S., & on behalf of the Canadian Neonatal Network (CNN) Investigators. (2022). Association of Weight Changes by Three Days after Birth and Mortality and/or Severe Neurological Injury in Preterm Infants < 29 Weeks Gestational Age: A Multicenter Cohort Study. Children, 9(2), 276. https://doi.org/10.3390/children9020276

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