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Volume 10
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10.3390/children10030572
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Background:
Systematic Review

Physical Activity as a Treatment for Cancer-Related Fatigue in Children, Adolescents and Young Adults: A Systematic Review

by
Mareike Kuehn
1,†,
Lena Wypyrsczyk
1,†,
Sandra Stoessel
1,
Marie A. Neu
1,
Lisa Ploch
1,
Elias Dreismickenbecker
1,
Perikles Simon
2 and
Joerg Faber
1,*
1
Center for Pediatric and Adolescent Medicine, Department of Pediatric Hematology/Oncology, University Medical Center of the Johannes Gutenberg—University Mainz, 55131 Mainz, Germany
2
Institute of Sport Science, Department Sport Medicine, Rehabilitation and Disease Prevention, Johannes Gutenberg University, 55128 Mainz, Germany
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Children 2023, 10(3), 572; https://doi.org/10.3390/children10030572
Submission received: 25 January 2023 / Revised: 6 March 2023 / Accepted: 15 March 2023 / Published: 17 March 2023
(This article belongs to the Special Issue Recent Progress in Pediatric Hematology-Oncology)
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Abstract

Background: Cancer-related fatigue (CRF) is one of the most common and distressing symptoms in paediatric oncology. Based on previous studies, physical activity interventions are considered to be effective in reducing CRF in adult cancer patients. Aim: The aim of this systematic review is to investigate whether physical activity interventions can reduce CRF in paediatric patients undergoing cancer treatment. Methodology: A systematic literature search was conducted in PubMed and Sport-Discus in October 2021 to identify intervention studies examining the effects of physical activity on CRF in cancer patients ≤ 21 years of age. Their methodological quality was assessed using the JBI Critical Appraisal Tool. Results: A total of 20 studies (seven randomized-controlled, six quasi-experimental and seven single-arm intervention trials) were included in the review. Nine studies reported significant positive effects of physical activity interventions on CRF in group comparison or within groups. Eleven trials reported no significant changes in CRF. Conclusion: Physical activity as a therapeutic intervention in paediatric oncology may have the potential to reduce CRF in childhood cancer patients undergoing cancer treatment. Further high-quality studies with large samples are needed to verify these results and to assess the interdependence of dose and response of physical activity interventions.
Keywords: cancer-related fatigue; childhood cancer; physical activity; exercise; systematic review cancer-related fatigue; childhood cancer; physical activity; exercise; systematic review
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MDPI and ACS Style

Kuehn, M.; Wypyrsczyk, L.; Stoessel, S.; Neu, M.A.; Ploch, L.; Dreismickenbecker, E.; Simon, P.; Faber, J. Physical Activity as a Treatment for Cancer-Related Fatigue in Children, Adolescents and Young Adults: A Systematic Review. Children 2023, 10, 572. https://doi.org/10.3390/children10030572

AMA Style

Kuehn M, Wypyrsczyk L, Stoessel S, Neu MA, Ploch L, Dreismickenbecker E, Simon P, Faber J. Physical Activity as a Treatment for Cancer-Related Fatigue in Children, Adolescents and Young Adults: A Systematic Review. Children. 2023; 10(3):572. https://doi.org/10.3390/children10030572

Chicago/Turabian Style

Kuehn, Mareike, Lena Wypyrsczyk, Sandra Stoessel, Marie A. Neu, Lisa Ploch, Elias Dreismickenbecker, Perikles Simon, and Joerg Faber. 2023. "Physical Activity as a Treatment for Cancer-Related Fatigue in Children, Adolescents and Young Adults: A Systematic Review" Children 10, no. 3: 572. https://doi.org/10.3390/children10030572

APA Style

Kuehn, M., Wypyrsczyk, L., Stoessel, S., Neu, M. A., Ploch, L., Dreismickenbecker, E., Simon, P., & Faber, J. (2023). Physical Activity as a Treatment for Cancer-Related Fatigue in Children, Adolescents and Young Adults: A Systematic Review. Children, 10(3), 572. https://doi.org/10.3390/children10030572

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