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Volume 11
Issue 9
10.3390/biomedicines11092382
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Article

The Role of Polymorphism in the Endothelial Homeostasis and Vitamin D Metabolism Genes in the Severity of Coronary Artery Disease

by
Anastasia Ponasenko
,
Anna Sinitskaya
,
Maxim Sinitsky
*,
Maria Khutornaya
and
Olga Barbarash
Research Institute for Complex Issues of Cardiovascular Diseases, 650002 Kemerovo, Russia
*
Author to whom correspondence should be addressed.
Biomedicines 2023, 11(9), 2382; https://doi.org/10.3390/biomedicines11092382
Submission received: 16 June 2023 / Revised: 2 August 2023 / Accepted: 5 August 2023 / Published: 25 August 2023
(This article belongs to the Special Issue Molecular and Cellular Mechanisms of CVD: Focus on Atherosclerosis)
Versions Notes

Abstract

Coronary artery disease (CAD) remains one of the leading causes of cardiovascular morbidity and mortality worldwide. The maintenance of endothelial homeostasis and vitamin D metabolism play an important role in CAD pathogenesis. This study aimed to determine the association of endothelial homeostasis and vitamin D metabolism gene polymorphism with CAD severity. A total of 224 low-risk patients (SYNTAX score ≤ 31) and 36 high-risk patients (SYNTAX score > 31) were recruited for this study. The serum level of E-, L- and P-selectins; endothelin; eNOS; 25OH; and 1.25-dihydroxy vitamin D was measured using an enzyme-linked immunosorbent assay (ELISA). Polymorphic variants in SELE, SELP, SELPLG, END1, NOS3, VDR and GC were analyzed using a polymerase chain reaction (PCR). We found no differences in the serum levels of the studied markers between high- and low-risk patients. Three polymorphic variants associated with CAD severity were discovered: END1 rs3087459, END1 rs5370 and GC rs2298849 in the log-additive model. Moreover, we discovered a significantly decreased serum level of 1.25-dihydroxy vitamin D in high-risk CAD patients with the A/A–A/G genotypes of the rs2228570 polymorphism of the VDR gene, the A/A genotype of the rs7041 polymorphism of the GC gene and the A/A genotype of the rs2298849 polymorphism of the GC gene.
Keywords: cardiovascular diseases; coronary artery disease; SYNTAX; endothelial homeostasis; vitamin D; genetic polymorphism; ELISA cardiovascular diseases; coronary artery disease; SYNTAX; endothelial homeostasis; vitamin D; genetic polymorphism; ELISA

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MDPI and ACS Style

Ponasenko, A.; Sinitskaya, A.; Sinitsky, M.; Khutornaya, M.; Barbarash, O. The Role of Polymorphism in the Endothelial Homeostasis and Vitamin D Metabolism Genes in the Severity of Coronary Artery Disease. Biomedicines 2023, 11, 2382. https://doi.org/10.3390/biomedicines11092382

AMA Style

Ponasenko A, Sinitskaya A, Sinitsky M, Khutornaya M, Barbarash O. The Role of Polymorphism in the Endothelial Homeostasis and Vitamin D Metabolism Genes in the Severity of Coronary Artery Disease. Biomedicines. 2023; 11(9):2382. https://doi.org/10.3390/biomedicines11092382

Chicago/Turabian Style

Ponasenko, Anastasia, Anna Sinitskaya, Maxim Sinitsky, Maria Khutornaya, and Olga Barbarash. 2023. "The Role of Polymorphism in the Endothelial Homeostasis and Vitamin D Metabolism Genes in the Severity of Coronary Artery Disease" Biomedicines 11, no. 9: 2382. https://doi.org/10.3390/biomedicines11092382

APA Style

Ponasenko, A., Sinitskaya, A., Sinitsky, M., Khutornaya, M., & Barbarash, O. (2023). The Role of Polymorphism in the Endothelial Homeostasis and Vitamin D Metabolism Genes in the Severity of Coronary Artery Disease. Biomedicines, 11(9), 2382. https://doi.org/10.3390/biomedicines11092382

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