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Open AccessArticle

Lignin and Cellulose Blends as Pharmaceutical Excipient for Tablet Manufacturing via Direct Compression

1
School of Pharmacy, Queen’s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK
2
Instituto de Cerámica y Vidrio, CSIC, Calle Kelsen, 5, 28049 Madrid, Spain
*
Author to whom correspondence should be addressed.
Biomolecules 2019, 9(9), 423; https://doi.org/10.3390/biom9090423
Received: 5 July 2019 / Revised: 7 August 2019 / Accepted: 23 August 2019 / Published: 28 August 2019
(This article belongs to the Special Issue Carbohydrate Polymers: Science and Applications)
Extensive efforts are being made to find alternative uses for lignin (LIG). In the present work the use of this biopolymer as excipient to prepare tablets was studied. For this purpose, LIG was combined with microcrystalline cellulose (MCC) and used as excipients to prepare directly compressed tablets containing a model drug, tetracycline (TC). The excipients contained different concentrations of LIG: 100%, 75%, 50%, 25% and 0% (w/w). Two different compression forces were used (two and five tonnes). When formulations were prepared using LIG as the only excipient, tablets were formed, but they showed lower densities and crushing strength than the ones obtained with only MCC or LIG/MCC blends. Moreover, tablets prepared using five tonnes of compression force showed TC releases ranging from 40% to 70% of the drug loading. On the other hand, the tablets prepared using two tonnes of compression force showed a faster and more efficient TC release, between 60% and 90%. The presence of LIG in the tablets modified significantly the release profile and the maximum amount of TC released. Finally, a DPPH (2,2-diphenyl-1-picrylhydrozyl) assay was performed to confirm that the presence of LIG provided antioxidant properties to the formulations. Accordingly, LIG has potential as a pharmaceutical excipient. View Full-Text
Keywords: lignin; microcrystalline cellulose; pharmaceutical excipients; direct compression; tablets; tetracycline lignin; microcrystalline cellulose; pharmaceutical excipients; direct compression; tablets; tetracycline
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MDPI and ACS Style

Domínguez-Robles, J.; Stewart, S.A.; Rendl, A.; González, Z.; Donnelly, R.F.; Larrañeta, E. Lignin and Cellulose Blends as Pharmaceutical Excipient for Tablet Manufacturing via Direct Compression. Biomolecules 2019, 9, 423.

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