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Biomolecules 2019, 9(2), 64; https://doi.org/10.3390/biom9020064

Palm Oil in Lipid-Based Formulations and Drug Delivery Systems

1
Department of Biochemistry, Faculty of Medicine, Universiti Teknologi MARA (UiTM), Cawangan Selangor, 47000 Sungai Buloh, Selangor, Malaysia
2
Institute of Medical Molecular Biotechnology (IMMB), Faculty of Medicine, Universiti Teknologi MARA (UiTM), Cawangan Selangor, 47000 Sungai Buloh, Selangor, Malaysia
3
Atta-ur-Rahman Institute for Natural Products Discovery (AuRIns), Faculty of Pharmacy, Universiti Teknologi MARA, 42300 Puncak Alam, Cawangan Selangor, Selangor, Malaysia
*
Authors to whom correspondence should be addressed.
Received: 29 November 2018 / Revised: 7 February 2019 / Accepted: 7 February 2019 / Published: 13 February 2019
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Abstract

Palm oil is natural oil packed with important compounds and fatty acids ready to be exploited in lipid-based formulations and drug delivery. Palm oil and palm kernel oil contain long-chain and medium-chain triglycerides, respectively, including phytonutrients such as tocotrienol, tocopherol and carotenes. The exploitation of these compounds in a lipid-based formulation would be able to address hydrophobicity, lipophilicity, poor bioavailability and low water-solubility of many current drugs. The utilisation of palm oil as part of the drug delivery system seemed to improve the bioavailability and solubility of the drug, stabilising emulsification of formulation between emulsifier and surfactant, promoting enhanced drug permeability and performance, as well as extending the shelf-life of the drug. Despite the complexity in designing lipid-based formulations, palm oil has proven to offer dynamic behaviour in providing versatility in drug design, form and delivery. However, the knowledge and application of palm oil and its fractions in lipid-based formulation are scarce and interspersed. Therefore, this study aims to focus on the research and outcomes of using palm oil in lipid-based formulations and drug delivery systems, due to the importance of establishing its capabilities and benefits. View Full-Text
Keywords: palm oil; palm kernel oil; palm fatty acids; medium-chain triglycerides; lipid-based formulation; drug delivery system palm oil; palm kernel oil; palm fatty acids; medium-chain triglycerides; lipid-based formulation; drug delivery system
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Efendy Goon, D.; Sheikh Abdul Kadir, S.H.; Latip, N.A.; Rahim, S.A.; Mazlan, M. Palm Oil in Lipid-Based Formulations and Drug Delivery Systems. Biomolecules 2019, 9, 64.

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