Polysaccharide-Based Systems for Targeted Stem Cell Differentiation and Bone Regeneration
by
Markus Witzler 1
, Dominik Büchner 1, Sarah Hani Shoushrah 1, Patrick Babczyk 1, Juliana Baranova 2, Steffen Witzleben 1, Edda Tobiasch 1 and Margit Schulze 1,*
Markus Witzler 1, Dominik Büchner 1, Sarah Hani Shoushrah 1, Patrick Babczyk 1, Juliana Baranova 2, Steffen Witzleben 1, Edda Tobiasch 1 and Margit Schulze 1,*
1
Department of Natural Sciences, Bonn-Rhein-Sieg University of Applied Sciences, von-Liebig-Str. 20, 53359 Rheinbach, Germany
2
Laboratory of Neurosciences, Department of Biochemistry, Institute of Chemistry–USP, University of São Paulo, Avenida Professor Lineu Prestes 748, Vila Universitaria, São Paulo, SP 05508-000, Brazil
*
Author to whom correspondence should be addressed.
Biomolecules 2019, 9(12), 840; https://doi.org/10.3390/biom9120840
Received: 21 October 2019 / Revised: 22 November 2019 / Accepted: 3 December 2019 / Published: 6 December 2019
(This article belongs to the Special Issue New Targets and Strategies in Regenerative Medicine)
Bone tissue engineering is an ever-changing, rapidly evolving, and highly interdisciplinary field of study, where scientists try to mimic natural bone structure as closely as possible in order to facilitate bone healing. New insights from cell biology, specifically from mesenchymal stem cell differentiation and signaling, lead to new approaches in bone regeneration. Novel scaffold and drug release materials based on polysaccharides gain increasing attention due to their wide availability and good biocompatibility to be used as hydrogels and/or hybrid components for drug release and tissue engineering. This article reviews the current state of the art, recent developments, and future perspectives in polysaccharide-based systems used for bone regeneration.
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Keywords:
polysaccharide; composites; bone tissue engineering; stem cells; osteogenesis; angiogenesis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Witzler, M.; Büchner, D.; Shoushrah, S.H.; Babczyk, P.; Baranova, J.; Witzleben, S.; Tobiasch, E.; Schulze, M. Polysaccharide-Based Systems for Targeted Stem Cell Differentiation and Bone Regeneration. Biomolecules 2019, 9, 840.
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