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Open AccessFeature PaperArticle

N-glycomic Profile in Combat Related Post-Traumatic Stress Disorder

1
Laboratory for Molecular Neuropsychiatry, Division of Molecular Medicine, Rudjer Boskovic Institute, 10000 Zagreb, Croatia
2
Department for Biological Psychiatry and Psychogeriatrics, University Hospital Vrapce, 10000 Zagreb, Croatia
3
School of Medicine, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia
4
Psychiatry and Behavioral Neurosciences, Wayne State University Detroit, MI 48202, USA
5
Genos Ltd., Glycobiology Laboratory, 10000 Zagreb, Croatia
*
Author to whom correspondence should be addressed.
Biomolecules 2019, 9(12), 834; https://doi.org/10.3390/biom9120834
Received: 22 October 2019 / Revised: 2 December 2019 / Accepted: 3 December 2019 / Published: 6 December 2019
(This article belongs to the Special Issue 2019 Feature Papers by Biomolecules’ Editorial Board Members)
Post-traumatic stress disorder (PTSD) develops in a portion of individuals exposed to extreme trauma. Glycosylation is a post-translational modification that affects protein functions and is altered in various pathophysiological states and aging. There are still no validated biomarkers of PTSD. The aim of this study was to evaluate the N-glycomic profile in 543 male Caucasian individuals (299 veterans with PTSD and 244 control subjects). The study included discovery (N = 233) and replication (N = 310) cohort. Hydrophilic interaction HPLC and ultra-performance liquid chromatography were used to separate and detect 39 plasma and 24 IgG N-glycan species, respectively. All results were corrected for the effects of age and multiple testing. Significant results included only significantly altered N-glycans in cases/controls in both cohorts, in the same direction. Results showed that six plasma N-glycans (four increased and two decreased) were altered in PTSD vs. controls in both cohorts, but IgG N-glycans were similar between groups. The severity of PTSD was not associated with different plasma N-glycans. This is the first study detecting alterations in plasma N-glycans in PTSD. These N-glycans are also associated with other neuropsychiatric disorders and inflammation, suggesting possible shared glycosylation mechanisms. View Full-Text
Keywords: biomarkers; Caucasians; immunoglobulin G; male subjects; N-glycans; plasma; PTSD; veterans biomarkers; Caucasians; immunoglobulin G; male subjects; N-glycans; plasma; PTSD; veterans
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Tudor, L.; Nedic Erjavec, G.; Nikolac Perkovic, M.; Konjevod, M.; Svob Strac, D.; Uzun, S.; Kozumplik, O.; Jovanovic, T.; Lauc, G.; Pivac, N. N-glycomic Profile in Combat Related Post-Traumatic Stress Disorder. Biomolecules 2019, 9, 834.

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