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Review

Engineering Extracellular Vesicles as Nanotherapeutics for Regenerative Medicine

1
Surgical Bioengineering Laboratory, Department of Surgery, School of Medicine, University of California–Davis, Sacramento, CA 95817, USA
2
Department of Biomedical Engineering, University of California–Davis, Davis, CA 95616, USA
3
Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children–Northern California, Sacramento, CA 95817, USA
*
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(1), 48; https://doi.org/10.3390/biom10010048
Received: 10 December 2019 / Revised: 24 December 2019 / Accepted: 26 December 2019 / Published: 28 December 2019
(This article belongs to the Special Issue New Targets and Strategies in Regenerative Medicine)
Long thought of to be vesicles that primarily recycled waste biomolecules from cells, extracellular vesicles (EVs) have now emerged as a new class of nanotherapeutics for regenerative medicine. Recent studies have proven their potential as mediators of cell proliferation, immunomodulation, extracellular matrix organization and angiogenesis, and are currently being used as treatments for a variety of diseases and injuries. They are now being used in combination with a variety of more traditional biomaterials and tissue engineering strategies to stimulate tissue repair and wound healing. However, the clinical translation of EVs has been greatly slowed due to difficulties in EV isolation and purification, as well as their limited yields and functional heterogeneity. Thus, a field of EV engineering has emerged in order to augment the natural properties of EVs and to recapitulate their function in semi-synthetic and synthetic EVs. Here, we have reviewed current technologies and techniques in this growing field of EV engineering while highlighting possible future applications for regenerative medicine. View Full-Text
Keywords: extracellular vesicles; regenerative medicine; biomaterials; stem cells extracellular vesicles; regenerative medicine; biomaterials; stem cells
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MDPI and ACS Style

Ramasubramanian, L.; Kumar, P.; Wang, A. Engineering Extracellular Vesicles as Nanotherapeutics for Regenerative Medicine. Biomolecules 2020, 10, 48. https://doi.org/10.3390/biom10010048

AMA Style

Ramasubramanian L, Kumar P, Wang A. Engineering Extracellular Vesicles as Nanotherapeutics for Regenerative Medicine. Biomolecules. 2020; 10(1):48. https://doi.org/10.3390/biom10010048

Chicago/Turabian Style

Ramasubramanian, Lalithasri, Priyadarsini Kumar, and Aijun Wang. 2020. "Engineering Extracellular Vesicles as Nanotherapeutics for Regenerative Medicine" Biomolecules 10, no. 1: 48. https://doi.org/10.3390/biom10010048

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