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Open AccessReview

Natural Ergot Alkaloids in Ocular Pharmacotherapy: Known Molecules for Novel Nanoparticle-Based Delivery Systems

1
Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Av. do Café s/n, Ribeirão Preto, SP 14040-903, Brazil
2
CEB—Centre of Biological Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal
3
Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar 125001, Haryana, India
4
Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak 124001, Haryana, India
5
CREA-Research Centre for Food and Nutrition, Via Ardeatina 546, 00178 Rome, Italy
6
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal
7
Department of Agricultural Sciences, University of Napoli Federico II, Via Università 100, 80055 Portici, Italy
8
Department of Endocrinology, Hospital de São João, Alameda Prof. Hernâni Monteiro, 4200–319 Porto, Portugal
9
Department of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy
*
Authors to whom correspondence should be addressed.
Biomolecules 2020, 10(7), 980; https://doi.org/10.3390/biom10070980
Received: 12 May 2020 / Revised: 26 June 2020 / Accepted: 28 June 2020 / Published: 30 June 2020
(This article belongs to the Special Issue Pharmacology of Medicinal Plants)
Several pharmacological properties are attributed to ergot alkaloids as a result of their antibacterial, antiproliferative, and antioxidant effects. Although known for their biomedical applications (e.g., for the treatment of glaucoma), most ergot alkaloids exhibit high toxicological risk and may even be lethal to humans and animals. Their pharmacological profile results from the structural similarity between lysergic acid-derived compounds and noradrenalin, dopamine, and serotonin neurotransmitters. To reduce their toxicological risk, while increasing their bioavailability, improved delivery systems were proposed. This review discusses the safety aspects of using ergot alkaloids in ocular pharmacology and proposes the development of lipid and polymeric nanoparticles for the topical administration of these drugs to enhance their therapeutic efficacy for the treatment of glaucoma. View Full-Text
Keywords: ergot alkaloids; ocular pharmacology; glaucoma; lipid nanoparticles; polymeric nanoparticles ergot alkaloids; ocular pharmacology; glaucoma; lipid nanoparticles; polymeric nanoparticles
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MDPI and ACS Style

Baldim, I.; Oliveira, W.P.; Kadian, V.; Rao, R.; Yadav, N.; Mahant, S.; Lucarini, M.; Durazzo, A.; Da Ana, R.; Capasso, R.; Souto, S.B.; Santini, A.; Souto, E.B. Natural Ergot Alkaloids in Ocular Pharmacotherapy: Known Molecules for Novel Nanoparticle-Based Delivery Systems. Biomolecules 2020, 10, 980.

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