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The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial Pyruvate Carrier

Department of Cell Biology, Faculty of Sciences, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneva 4, Switzerland
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Biomolecules 2020, 10(7), 1068; https://doi.org/10.3390/biom10071068
Received: 18 June 2020 / Revised: 9 July 2020 / Accepted: 14 July 2020 / Published: 17 July 2020
(This article belongs to the Special Issue Mitochondrial Transport Proteins)
Pyruvate, the end product of glycolysis, plays a major role in cell metabolism. Produced in the cytosol, it is oxidized in the mitochondria where it fuels the citric acid cycle and boosts oxidative phosphorylation. Its sole entry point into mitochondria is through the recently identified mitochondrial pyruvate carrier (MPC). In this review, we report the latest findings on the physiology of the MPC and we discuss how a dysfunctional MPC can lead to diverse pathologies, including neurodegenerative diseases, metabolic disorders, and cancer. View Full-Text
Keywords: mitochondria; mitochondrial pyruvate carrier; metabolism; neurodegeneration; metabolic disorders; cancer mitochondria; mitochondrial pyruvate carrier; metabolism; neurodegeneration; metabolic disorders; cancer
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MDPI and ACS Style

Zangari, J.; Petrelli, F.; Maillot, B.; Martinou, J.-C. The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial Pyruvate Carrier. Biomolecules 2020, 10, 1068. https://doi.org/10.3390/biom10071068

AMA Style

Zangari J, Petrelli F, Maillot B, Martinou J-C. The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial Pyruvate Carrier. Biomolecules. 2020; 10(7):1068. https://doi.org/10.3390/biom10071068

Chicago/Turabian Style

Zangari, Joséphine, Francesco Petrelli, Benoît Maillot, and Jean-Claude Martinou. 2020. "The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial Pyruvate Carrier" Biomolecules 10, no. 7: 1068. https://doi.org/10.3390/biom10071068

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