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Open AccessReview

Therapeutic Potential of Brassinosteroids in Biomedical and Clinical Research

1
Plant Stress Physiology Lab, Department of Botanical and Environment Sciences, Guru Nanak Dev University, Amritsar 143005, Punjab, India
2
Department of Bio-organic and Biological Chemistry, Kharkiv National Medical University, Kharkiv 61000, Ukraine
3
State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, Hangzhou 311300, China
4
Department of Molecular Biology and Biochemistry, Guru Nanak Dev University, Amritsar 143005, Punjab, India
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Department of Agriculture, Food & Environment, University of Pisa, Via del Borghetto 80, 56124 Pisa, Italy
6
Interdepartmental Research Center Nutrafood “Nutraceuticals and Food for Health”, University of Pisa, Via del Borghetto 80, 56124 Pisa, Italy
*
Authors to whom correspondence should be addressed.
Biomolecules 2020, 10(4), 572; https://doi.org/10.3390/biom10040572
Received: 14 January 2020 / Revised: 28 March 2020 / Accepted: 3 April 2020 / Published: 9 April 2020
(This article belongs to the Special Issue Pharmacology of Medicinal Plants)
Steroids are a pivotal class of hormones with a key role in growth modulation and signal transduction in multicellular organisms. Synthetic steroids are widely used to cure large array of viral, fungal, bacterial, and cancerous infections. Brassinosteroids (BRs) are a natural collection of phytosterols, which have structural similarity with animal steroids. BRs are dispersed universally throughout the plant kingdom. These plant steroids are well known to modulate a plethora of physiological responses in plants leading to improvement in quality as well as yield of food crops. Moreover, they have been found to play imperative role in stress-fortification against various stresses in plants. Over a decade, BRs have conquered worldwide interest due to their diverse biological activities in animal systems. Recent studies have indicated anticancerous, antiangiogenic, antiviral, antigenotoxic, antifungal, and antibacterial bioactivities of BRs in the animal test systems. BRs inhibit replication of viruses and induce cytotoxic effects on cancerous cell lines. Keeping in view the biological activities of BRs, this review is an attempt to update the information about prospects of BRs in biomedical and clinical application. View Full-Text
Keywords: brassinosteroids; anticancerous; antiviral; antibacterial; ecdysteroidal activities brassinosteroids; anticancerous; antiviral; antibacterial; ecdysteroidal activities
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MDPI and ACS Style

Kaur Kohli, S.; Bhardwaj, A.; Bhardwaj, V.; Sharma, A.; Kalia, N.; Landi, M.; Bhardwaj, R. Therapeutic Potential of Brassinosteroids in Biomedical and Clinical Research. Biomolecules 2020, 10, 572.

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