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Open AccessArticle

The Ser290Asn and Thr715Pro Polymorphisms of the SELP Gene Are Associated with A Lower Risk of Developing Acute Coronary Syndrome and Low Soluble P-Selectin Levels in A Mexican Population

1
Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico
2
Department of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico
3
Laboratory of Translational Medicine, UNAM-INC Research Unit, Instituto Nacional de Cardiología, Ignacio Chávez, Mexico City, Mexico
4
Commissioned of the Research Unit in Clinical Epidemiology, Hospital Regional No. 1, Dr. Carlos McGregor Sánchez Navarro, Instituto Mexicano del Seguro Social, Mexico City, Mexico
5
Unit of the Experimental Medicine, Hospital General de Mexico, Dr. Eduardo Liceaga, Mexico City, Mexico
*
Author to whom correspondence should be addressed.
The contributions by G. Herrera-Maya and G. Vargas-Alarcón are equal and the order of authorship is arbitrary.
Running Head: SELP gene polymorphisms in acute coronary syndrome.
Biomolecules 2020, 10(2), 270; https://doi.org/10.3390/biom10020270
Received: 14 January 2020 / Revised: 4 February 2020 / Accepted: 10 February 2020 / Published: 11 February 2020
(This article belongs to the Special Issue Molecular Biomarkers In Cardiology)
Recent studies have shown that P-selectin promotes the early formation of atherosclerotic plaque. The aim of the present study was to evaluate whether the SELP gene single nucleotide polymorphisms (SNPs) are associated with presence of acute coronary syndrome (ACS) and with plasma P-selectin levels in a case-control association study. The sample size was estimated for a statistical power of 80%. We genotyped three SELP (SELP Ser290Asn, SELP Leu599Val, and SELP Thr715Pro) SNPs using 5’ exonuclease TaqMan assays in 625 patients with ACS and 700 healthy controls. The associations were evaluated with logistic regressions under the co-dominant, dominant, recessive, over-dominant and additive inheritance models. The genotype contribution to the plasma P-selectin levels was evaluated by a Student’s t-test. Under different models, the SELP Ser290Asn (OR = 0.59, pCCo-Dominant = 0.047; OR = 0.59, pCDominant = 0.014; OR = 0.58, pCOver-Dominant = 0.061, and OR = 0.62, pCAdditive = 0.015) and SELP Thr715Pro (OR = 0.61, pCDominant = 0.028; OR = 0.63, pCOver-Dominant = 0.044, and OR = 0.62, pCAdditive = 0.023) SNPs were associated with a lower risk of ACS. In addition, these SNPs were associated with low plasma P-selectin levels. In summary, this study established that the SELP Ser290Asn and SELP Thr715Pro SNPs are associated with a lower risk of developing ACS and with decreased P-selectin levels in plasma in a Mexican population.
Keywords: acute coronary syndrome; P-selectin; genetics; polymorphisms; susceptibility acute coronary syndrome; P-selectin; genetics; polymorphisms; susceptibility
MDPI and ACS Style

Herrera-Maya, G.; Vargas-Alarcón, G.; Pérez-Méndez, O.; Posadas-Sánchez, R.; Masso, F.; Juárez-Cedillo, T.; Escobedo, G.; Vázquez-Montero, A.; Fragoso, J.M. The Ser290Asn and Thr715Pro Polymorphisms of the SELP Gene Are Associated with A Lower Risk of Developing Acute Coronary Syndrome and Low Soluble P-Selectin Levels in A Mexican Population . Biomolecules 2020, 10, 270.

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