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Open AccessReview

Electrophiles Against (Skin) Diseases: More Than Nrf2

1
Department of Dermatology, University Hospital of Zurich, Gloriastrasse 31, CH-8091 Zurich, Switzerland
2
Faculty of Medicine, University of Zurich, Zurich, Switzerland
*
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(2), 271; https://doi.org/10.3390/biom10020271
Received: 18 December 2019 / Revised: 4 February 2020 / Accepted: 6 February 2020 / Published: 11 February 2020
The skin represents an indispensable barrier between the organism and the environment and is the first line of defense against exogenous insults. The transcription factor NRF2 is a central regulator of cytoprotection and stress resistance. NRF2 is activated in response to oxidative stress by reactive oxygen species (ROS) and electrophiles. These electrophiles oxidize specific cysteine residues of the NRF2 inhibitor KEAP1, leading to KEAP1 inactivation and, subsequently, NRF2 activation. As oxidative stress is associated with inflammation, the NRF2 pathway plays important roles in the pathogenesis of common inflammatory diseases and cancer in many tissues and organs, including the skin. The electrophile and NRF2 activator dimethyl fumarate (DMF) is an established and efficient drug for patients suffering from the common inflammatory skin disease psoriasis and the neuro-inflammatory disease multiple sclerosis (MS). In this review, we discuss possible molecular mechanisms underlying the therapeutic activity of DMF and other NRF2 activators. Recent evidence suggests that electrophiles not only activate NRF2, but also target other inflammation-associated pathways including the transcription factor NF-κB and the multi-protein complexes termed inflammasomes. Inflammasomes are central regulators of inflammation and are involved in many inflammatory conditions. Most importantly, the NRF2 and inflammasome pathways are connected at different levels, mainly antagonistically.
Keywords: NRF2; skin; inflammation; inflammasomes; electrophile; DMF; NF-κB NRF2; skin; inflammation; inflammasomes; electrophile; DMF; NF-κB
MDPI and ACS Style

Hennig, P.; Fenini, G.; Di Filippo, M.; Beer, H.-D. Electrophiles Against (Skin) Diseases: More Than Nrf2. Biomolecules 2020, 10, 271.

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