Next Article in Journal
Different Effects of Nicotine and N-Stearoyl-ethanolamine on Episodic Memory and Brain Mitochondria of α7 Nicotinic Acetylcholine Receptor Knockout Mice
Previous Article in Journal
Metabolic and Proteomic Perspectives of Augmentation of Nutritional Contents and Plant Defense in Vigna unguiculata
Open AccessReview

Testosterone and Adult Neurogenesis

Department of Biology, Middlebury College, Middlebury, VT 05753, USA
Graduate School of Education, Stanford University, Stanford, CA 94305, USA
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(2), 225;
Received: 11 December 2019 / Revised: 22 January 2020 / Accepted: 28 January 2020 / Published: 3 February 2020
(This article belongs to the Special Issue Hormonal Regulation of Neurogenesis in Adults)
It is now well established that neurogenesis occurs throughout adulthood in select brain regions, but the functional significance of adult neurogenesis remains unclear. There is considerable evidence that steroid hormones modulate various stages of adult neurogenesis, and this review provides a focused summary of the effects of testosterone on adult neurogenesis. Initial evidence came from field studies with birds and wild rodent populations. Subsequent experiments with laboratory rodents have tested the effects of testosterone and its steroid metabolites upon adult neurogenesis, as well as the functional consequences of induced changes in neurogenesis. These experiments have provided clear evidence that testosterone increases adult neurogenesis within the dentate gyrus region of the hippocampus through an androgen-dependent pathway. Most evidence indicates that androgens selectively enhance the survival of newly generated neurons, while having little effect on cell proliferation. Whether this is a result of androgens acting directly on receptors of new neurons remains unclear, and indirect routes involving brain-derived neurotrophic factor (BDNF) and glucocorticoids may be involved. In vitro experiments suggest that testosterone has broad-ranging neuroprotective effects, which will be briefly reviewed. A better understanding of the effects of testosterone upon adult neurogenesis could shed light on neurological diseases that show sex differences.
Keywords: testosterone; adult neurogenesis; androgen; hippocampus; dentate gyrus; sub-ventricular zone; BDNF; neuroprotection; spatial memory testosterone; adult neurogenesis; androgen; hippocampus; dentate gyrus; sub-ventricular zone; BDNF; neuroprotection; spatial memory
MDPI and ACS Style

Spritzer, M.D.; Roy, E.A. Testosterone and Adult Neurogenesis. Biomolecules 2020, 10, 225.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop