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Open AccessReview

The Role of Natural Compounds and their Nanocarriers in the Treatment of CNS Inflammation

1
Department of Biomedicine, Health & Life Convergence Sciences, BK21 Four, Mokpo National University, Muan-gun, Jeonnam 58554, Korea
2
College of Pharmacy, Chungnam National University, Daejeon 34134, Korea
3
Department of Ophthalmology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu 41944, Korea
4
College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Muan-gun, Jeonnam 58554, Korea
5
College of Pharmacy, CMR1, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Korea
*
Authors to whom correspondence should be addressed.
Biomolecules 2020, 10(10), 1401; https://doi.org/10.3390/biom10101401
Received: 23 August 2020 / Revised: 25 September 2020 / Accepted: 26 September 2020 / Published: 1 October 2020
Neuroinflammation, which is involved in various inflammatory cascades in nervous tissues, can result in persistent and chronic apoptotic neuronal cell death and programmed cell death, triggering various degenerative disorders of the central nervous system (CNS). The neuroprotective effects of natural compounds against neuroinflammation are mainly mediated by their antioxidant, anti-inflammatory, and antiapoptotic properties that specifically promote or inhibit various molecular signal transduction pathways. However, natural compounds have several limitations, such as their pharmacokinetic properties and stability, which hinder their clinical development and use as medicines. This review discusses the molecular mechanisms of neuroinflammation and degenerative diseases of CNS. In addition, it emphasizes potential natural compounds and their promising nanocarriers for overcoming their limitations in the treatment of neuroinflammation. Moreover, recent promising CNS inflammation-targeted nanocarrier systems implementing lesion site-specific active targeting strategies for CNS inflammation are also discussed. View Full-Text
Keywords: neuroinflammation; central nervous system (CNS) degenerative diseases; natural compounds; neuroprotective; nanocarriers; blood–brain barrier (BBB); targeting neuroinflammation; central nervous system (CNS) degenerative diseases; natural compounds; neuroprotective; nanocarriers; blood–brain barrier (BBB); targeting
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MDPI and ACS Style

Khadka, B.; Lee, J.-Y.; Park, D.H.; Kim, K.-T.; Bae, J.-S. The Role of Natural Compounds and their Nanocarriers in the Treatment of CNS Inflammation. Biomolecules 2020, 10, 1401.

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