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Metabolites
Volume 12
Issue 2
10.3390/metabo12020128
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Communication

Diabetes-Induced Changes in Macrophage Biology Might Lead to Reduced Risk for Abdominal Aortic Aneurysm Development

by
Giulia Chinetti
1,*,†,
Joseph Carboni
2,†,
Joseph Murdaca
3,
Claudine Moratal
3,
Brigitte Sibille
3,
Juliette Raffort
1,
Fabien Lareyre
3,4,
Elixène Jean Baptiste
1,
Réda Hassen-Khodja
1 and
Jaap G. Neels
3,*
1
Centre Hospitalier Universitaire (CHU), Institut National de la Santé Et de la Recherche Médicale (INSERM), Centre Méditerranéen de Médecine Moléculaire (C3M), Université Côte d’Azur, 06200 Nice, France
2
Department of Vascular Surgery, Centre Hospitalier Universitaire (CHU), 06000 Nice, France
3
Institut National de la Santé Et de la Recherche Médicale (INSERM), Centre Méditerranéen de Médecine Moléculaire (C3M), Université Côte d’Azur, 06200 Nice, France
4
Department of Vascular Surgery, Hospital of Antibes Juan-les-Pins, 06160 Antibes, France
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Metabolites 2022, 12(2), 128; https://doi.org/10.3390/metabo12020128
Submission received: 17 December 2021 / Revised: 21 January 2022 / Accepted: 26 January 2022 / Published: 29 January 2022
(This article belongs to the Special Issue Insights into the Alteration of Lipid Metabolisms in Cardiometabolic Diseases)
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Abstract

Type 2 diabetes patients are less likely to develop an abdominal aortic aneurysm (AAA). Since macrophages play a crucial role in AAA development, we hypothesized that this decrease in AAA risk in diabetic patients might be due to diabetes-induced changes in macrophage biology. To test this hypothesis, we treated primary macrophages obtained from healthy human volunteers with serum from non-diabetic vs. diabetic AAA patients and observed differences in extracellular acidification and the expression of genes involved in glycolysis and lipid oxidation. These results suggest an increase in metabolism in macrophages treated with serum from diabetic AAA patients. Since serum samples used did not differ in glucose content, these changes are not likely to be caused by differences in glycemia. Macrophage functions have been shown to be linked to their metabolism. In line with this, our data suggest that this increase in macrophage metabolism is accompanied by a shift towards an anti-inflammatory state. Together, these results support a model where diabetes-induced changes in metabolism in macrophages might lead to a reduced risk for AAA development.
Keywords: macrophages; inflammation; metabolism; type 2 diabetes macrophages; inflammation; metabolism; type 2 diabetes

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MDPI and ACS Style

Chinetti, G.; Carboni, J.; Murdaca, J.; Moratal, C.; Sibille, B.; Raffort, J.; Lareyre, F.; Baptiste, E.J.; Hassen-Khodja, R.; Neels, J.G. Diabetes-Induced Changes in Macrophage Biology Might Lead to Reduced Risk for Abdominal Aortic Aneurysm Development. Metabolites 2022, 12, 128. https://doi.org/10.3390/metabo12020128

AMA Style

Chinetti G, Carboni J, Murdaca J, Moratal C, Sibille B, Raffort J, Lareyre F, Baptiste EJ, Hassen-Khodja R, Neels JG. Diabetes-Induced Changes in Macrophage Biology Might Lead to Reduced Risk for Abdominal Aortic Aneurysm Development. Metabolites. 2022; 12(2):128. https://doi.org/10.3390/metabo12020128

Chicago/Turabian Style

Chinetti, Giulia, Joseph Carboni, Joseph Murdaca, Claudine Moratal, Brigitte Sibille, Juliette Raffort, Fabien Lareyre, Elixène Jean Baptiste, Réda Hassen-Khodja, and Jaap G. Neels. 2022. "Diabetes-Induced Changes in Macrophage Biology Might Lead to Reduced Risk for Abdominal Aortic Aneurysm Development" Metabolites 12, no. 2: 128. https://doi.org/10.3390/metabo12020128

APA Style

Chinetti, G., Carboni, J., Murdaca, J., Moratal, C., Sibille, B., Raffort, J., Lareyre, F., Baptiste, E. J., Hassen-Khodja, R., & Neels, J. G. (2022). Diabetes-Induced Changes in Macrophage Biology Might Lead to Reduced Risk for Abdominal Aortic Aneurysm Development. Metabolites, 12(2), 128. https://doi.org/10.3390/metabo12020128

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