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Metabolites
Volume 11
Issue 8
10.3390/metabo11080519
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Review
Peer-Review Record

Mathematical Models for FDG Kinetics in Cancer: A Review

Metabolites 2021, 11(8), 519; https://doi.org/10.3390/metabo11080519
by Sara Sommariva 1,2,3, Giacomo Caviglia 2, Gianmario Sambuceti 4,5 and Michele Piana 1,2,3,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Metabolites 2021, 11(8), 519; https://doi.org/10.3390/metabo11080519
Submission received: 27 June 2021 / Revised: 28 July 2021 / Accepted: 2 August 2021 / Published: 6 August 2021
(This article belongs to the Special Issue Data Science in Metabolomics)

Round 1

Reviewer 1 Report

Although this paper has compiled many research models, it lacks comparisons of dynamical data of FDG-PET/the comprehension of cancer glucose metabolism or other indicators. It does not show the comparative advantages and disadvantages of various models.
Other minor suggestions:
1. Figure 5 needs to add a Y-axis label.
2. Some typos need to be checked, such as p.25 line 699 "TThese results..."

Author Response

please see attachment

Author Response File: Author Response.pdf

Reviewer 2 Report

The authors present great overview on mathematical modeling on compartmental modeling. Starting from simple models to more advanced, with nice explanations. I especially appreciate inclusion of the optimization methods and graphical models. Despite the context is very rich on information,  it is well explained and easy to follow. I sort of feel like I just undergo crushed course on compartmental modeling, and I believe other readers will benefit from this great overview.

 

I have few minor comments.

  • In the Patlak and Logan graphical approach. I think the methods are explained well, but being it a graphical approach it would be great if authors could include visual example (or point the reader to such resources).
  • It might be useful to the reader if authors could point us to some computational libraries and packages that could be used for compartmental analysis (if available of course).

Typos:

  • Page 1, line 31: typo: "densito"
  • Page 4: line 146: application OF a mathematical models
  • Page 5: line 218: diffusion may BE described by application of a continuous model.
  • Page 8: line 314:  (2-CM) should be 3-CM

 

Author Response

please see attchment

Author Response File: Author Response.pdf

Round 2

Reviewer 1 Report

Thank you for addressing my previous questions.

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