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Metabolites
Volume 11
Issue 7
10.3390/metabo11070453
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Article

Plasma Bile Acid Profile in Patients with and without Type 2 Diabetes

by
Alessandro Mantovani
1,*,
Andrea Dalbeni
2,
Denise Peserico
3,
Filippo Cattazzo
2,
Michele Bevilacqua
2,
Gian Luca Salvagno
3,
Giuseppe Lippi
3,
Giovanni Targher
1,
Elisa Danese
3,* and
Cristiano Fava
2
1
Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, 37126 Verona, Italy
2
Section of General Medicine C and Liver Unit, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, 37126 Verona, Italy
3
Section of Clinical Biochemistry, Department of Neurological, Biomedical and Movement Sciences, University of Verona, 37126 Verona, Italy
*
Authors to whom correspondence should be addressed.
Metabolites 2021, 11(7), 453; https://doi.org/10.3390/metabo11070453
Submission received: 14 June 2021 / Revised: 6 July 2021 / Accepted: 12 July 2021 / Published: 14 July 2021
(This article belongs to the Section Endocrinology and Clinical Metabolic Research)
Versions Notes

Abstract

A paucity of information currently exists on plasma bile acid (BA) profiles in patients with and without type 2 diabetes mellitus (T2DM). We assayed 14 plasma BA species in 224 patients with T2DM and in 102 nondiabetic individuals with metabolic syndrome. Plasma BA levels were measured with ultra-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) technique. Multivariable linear regression analyses were undertaken to assess associations between measured plasma BA species and T2DM status after adjustment for confounding factors. The presence of T2DM was significantly associated with higher plasma concentrations of both primary BAs (adjusted-standardized β coefficient: 0.279, p = 0.005) and secondary BAs (standardized β coefficient: 0.508, p < 0.001) after adjustment for age, sex, adiposity measures, serum alanine aminotransferase and use of statins or metformin. More specifically, the presence of T2DM was significantly associated with higher levels of plasma taurochenodeoxycholic acid, taurodeoxycholic acid, glycochenodeoxycholic acid, hyodeoxycholic acid, glycodeoxycholic acid, glycolithocholic acid, deoxycholic acid, taurochenodeoxycholic acid, taurodeoxycholic acid, glycochenodeoxycholic acid and glycodeoxycholic acid (adjusted-standardized β coefficients ranging from 0.315 to 0.600; p < 0.01 or less), as well as with lower plasma levels of cholic acid (adjusted-standardized β coefficient: −0.250, p = 0.013) and taurocholic acid (adjusted-standardized β coefficient: −0.309, p = 0.001). This study shows that there are marked differences in plasma BA profiles between patients with and without T2DM. Further research will be needed to better understand how these differences in plasma BA profiles may interplay with the pathophysiology of T2DM.
Keywords: type 2 diabetes; T2DM; bile acids; BA; metabolic syndrome type 2 diabetes; T2DM; bile acids; BA; metabolic syndrome

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MDPI and ACS Style

Mantovani, A.; Dalbeni, A.; Peserico, D.; Cattazzo, F.; Bevilacqua, M.; Salvagno, G.L.; Lippi, G.; Targher, G.; Danese, E.; Fava, C. Plasma Bile Acid Profile in Patients with and without Type 2 Diabetes. Metabolites 2021, 11, 453. https://doi.org/10.3390/metabo11070453

AMA Style

Mantovani A, Dalbeni A, Peserico D, Cattazzo F, Bevilacqua M, Salvagno GL, Lippi G, Targher G, Danese E, Fava C. Plasma Bile Acid Profile in Patients with and without Type 2 Diabetes. Metabolites. 2021; 11(7):453. https://doi.org/10.3390/metabo11070453

Chicago/Turabian Style

Mantovani, Alessandro, Andrea Dalbeni, Denise Peserico, Filippo Cattazzo, Michele Bevilacqua, Gian Luca Salvagno, Giuseppe Lippi, Giovanni Targher, Elisa Danese, and Cristiano Fava. 2021. "Plasma Bile Acid Profile in Patients with and without Type 2 Diabetes" Metabolites 11, no. 7: 453. https://doi.org/10.3390/metabo11070453

APA Style

Mantovani, A., Dalbeni, A., Peserico, D., Cattazzo, F., Bevilacqua, M., Salvagno, G. L., Lippi, G., Targher, G., Danese, E., & Fava, C. (2021). Plasma Bile Acid Profile in Patients with and without Type 2 Diabetes. Metabolites, 11(7), 453. https://doi.org/10.3390/metabo11070453

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