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Volume 10
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10.3390/metabo10090348
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Review

Bridging Targeted and Untargeted Mass Spectrometry-Based Metabolomics via Hybrid Approaches

by
Li Chen
1,2,
Fanyi Zhong
3 and
Jiangjiang Zhu
1,2,*
1
Department of Human Sciences, The Ohio State University, Columbus, OH 43210, USA
2
James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
3
Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, USA
*
Author to whom correspondence should be addressed.
Metabolites 2020, 10(9), 348; https://doi.org/10.3390/metabo10090348
Submission received: 26 July 2020 / Revised: 19 August 2020 / Accepted: 23 August 2020 / Published: 27 August 2020
(This article belongs to the Section Metabolomic Profiling Technology)
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Abstract

This mini-review aims to discuss the development and applications of mass spectrometry (MS)-based hybrid approaches in metabolomics. Several recently developed hybrid approaches are introduced. Then, the overall workflow, frequently used instruments, data handling strategies, and applications are compared and their pros and cons are summarized. Overall, the improved repeatability and quantitative capability in large-scale MS-based metabolomics studies are demonstrated, in comparison to either targeted or untargeted metabolomics approaches alone. In summary, we expect this review to serve as a first attempt to highlight the development and applications of emerging hybrid approaches in metabolomics, and we believe that hybrid metabolomics approaches could have great potential in many future studies.
Keywords: metabolomics; hybrid approaches; broad metabolite coverage; quantitative analysis; dynamic range; repeatability; identification metabolomics; hybrid approaches; broad metabolite coverage; quantitative analysis; dynamic range; repeatability; identification

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MDPI and ACS Style

Chen, L.; Zhong, F.; Zhu, J. Bridging Targeted and Untargeted Mass Spectrometry-Based Metabolomics via Hybrid Approaches. Metabolites 2020, 10, 348. https://doi.org/10.3390/metabo10090348

AMA Style

Chen L, Zhong F, Zhu J. Bridging Targeted and Untargeted Mass Spectrometry-Based Metabolomics via Hybrid Approaches. Metabolites. 2020; 10(9):348. https://doi.org/10.3390/metabo10090348

Chicago/Turabian Style

Chen, Li, Fanyi Zhong, and Jiangjiang Zhu. 2020. "Bridging Targeted and Untargeted Mass Spectrometry-Based Metabolomics via Hybrid Approaches" Metabolites 10, no. 9: 348. https://doi.org/10.3390/metabo10090348

APA Style

Chen, L., Zhong, F., & Zhu, J. (2020). Bridging Targeted and Untargeted Mass Spectrometry-Based Metabolomics via Hybrid Approaches. Metabolites, 10(9), 348. https://doi.org/10.3390/metabo10090348

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