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Open AccessArticle

Microbiome-Metabolome Signature of Acute Kidney Injury

1
Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow 119992, Russia
2
A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119992, Russia
3
V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, Moscow 117997, Russia
4
Atlas Biomed Group - Knomics LLC, Skolkovo Innovation center, Moscow 143026, Russia
5
Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology, Russian Academy of Sciences, Moscow 119334, Russia
6
Research Centre for Medical Genetics, Moscow 115522, Russia
7
Institute of Mitoengineering MSU» LLC, Leninskiye Gory 1, 119192 Moscow, Russia
8
Sechenov First Moscow State Medical University, Institute of Molecular Medicine, Moscow 119991, Russia
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this paper.
Metabolites 2020, 10(4), 142; https://doi.org/10.3390/metabo10040142
Received: 27 February 2020 / Revised: 31 March 2020 / Accepted: 1 April 2020 / Published: 4 April 2020
(This article belongs to the Special Issue Metabolomics and Microbiota Metabolism)
Intestinal microbiota play a considerable role in the host’s organism, broadly affecting its organs and tissues. The kidney can also be the target of the microbiome and its metabolites (especially short-chain fatty acids), which can influence renal tissue, both by direct action and through modulation of the immune response. This impact is crucial, especially during kidney injury, because the modulation of inflammation or reparative processes could affect the severity of the resulting damage or recovery of kidney function. In this study, we compared the composition of rat gut microbiota with its outcome, in experimental acute ischemic kidney injury and named the bacterial taxa that play putatively negative or positive roles in the progression of ischemic kidney injury. We investigated the link between serum creatinine, urea, and a number of metabolites (acylcarnitines and amino acids), and the relative abundance of various bacterial taxa in rat feces. Our analysis revealed an increase in levels of 32 acylcarnitines in serum, after renal ischemia/reperfusion and correlation with creatinine and urea, while levels of three amino acids (tyrosine, tryptophan, and proline) had decreased. We detected associations between bacterial abundance and metabolite levels, using a compositionality-aware approach—Rothia and Staphylococcus levels were positively associated with creatinine and urea levels, respectively. Our findings indicate that the gut microbial community contains specific members whose presence might ameliorate or, on the contrary, aggravate ischemic kidney injury. These bacterial taxa could present perspective targets for therapeutical interventions in kidney pathologies, including acute kidney injury. View Full-Text
Keywords: acute kidney injury; microbiota; fecal bacteria; 16S rRNA gene sequencing; metabolites; bacterial balances; creatinine; urea acute kidney injury; microbiota; fecal bacteria; 16S rRNA gene sequencing; metabolites; bacterial balances; creatinine; urea
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Andrianova, N.V.; Popkov, V.A.; Klimenko, N.S.; Tyakht, A.V.; Baydakova, G.V.; Frolova, O.Y.; Zorova, L.D.; Pevzner, I.B.; Zorov, D.B.; Plotnikov, E.Y. Microbiome-Metabolome Signature of Acute Kidney Injury. Metabolites 2020, 10, 142.

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