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Open AccessArticle

Identification of the Main Metabolites of a Marine-Derived Strain of Penicillium brevicompactum Using LC and GC MS Techniques

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Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, 80137 Naples, Italy
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Institute for Sustainable Plant Protection, National Research Council, 80055 Portici (NA), Italy
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Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy
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Council for Agricultural Research and Economics, Research Centre for Olive, Citrus and Tree Fruit,81100 Caserta, Italy
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Department of Agricultural Sciences, University of Naples Federico II, 80055 Portici (NA), Italy
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Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy
*
Author to whom correspondence should be addressed.
Metabolites 2020, 10(2), 55; https://doi.org/10.3390/metabo10020055
Received: 17 December 2019 / Revised: 21 January 2020 / Accepted: 27 January 2020 / Published: 30 January 2020
(This article belongs to the Special Issue Metabolomics in Multicomponent Interactions)
Marine-derived fungi are an important source of many valuable compounds with original structures and diverse physico-chemical properties. In this work, the metabolomic profile of a strain of Penicillium brevicompactum, recovered from a snakelocks sea anemone (Anemonia sulcata), was investigated through the parallel application of LC-ESI-HRMS, GC-MS, and NMR. Our strategy allowed the identification of mycophenolic acid, brevianamide A, and several compounds belonging to the thiosilvatins. Among the latter, five products are reported for the first time in this species. The main product of this series, cis-bis(methylthio)silvatin, was also tested for antiproliferative activity on both cancer and non-tumoral colon cell lines.
Keywords: epidithiodioxopiperazines; marine-derived fungi; antiproliferative activity; Anemonia sulcata; mycophenolic acid; thiosilvatins; beneficial microbes epidithiodioxopiperazines; marine-derived fungi; antiproliferative activity; Anemonia sulcata; mycophenolic acid; thiosilvatins; beneficial microbes
MDPI and ACS Style

Vinale, F.; Salvatore, M.M.; Nicoletti, R.; Staropoli, A.; Manganiello, G.; Venneri, T.; Borrelli, F.; DellaGreca, M.; Salvatore, F.; Andolfi, A. Identification of the Main Metabolites of a Marine-Derived Strain of Penicillium brevicompactum Using LC and GC MS Techniques. Metabolites 2020, 10, 55.

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