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Validation of a SPICE Model for High Frequency Electroporation Systems

Department of Electrical Engineering, Faculty of Electronics, Vilnius Gediminas Technical University, Sauletekio al. 11, Vilnius 10221, Lithuania
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Electronics 2019, 8(6), 710; https://doi.org/10.3390/electronics8060710
Received: 29 May 2019 / Revised: 11 June 2019 / Accepted: 20 June 2019 / Published: 23 June 2019
(This article belongs to the Section Circuit and Signal Processing)
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Abstract

In this paper, we present an analysis and a validation of a simulation program with integrated circuit emphasis (SPICE) model for a pulse forming circuit of a high frequency electroporation system, which can deliver square-wave sub-microsecond (100–900 ns) electric field pulses. The developed SPICE model is suggested for use in evaluation of transient processes that occur due to high frequency operations in prototype systems. A controlled crowbar circuit was implemented to support a variety of biological loads and to ensure a constant electric pulse rise and fall time during electroporation to be independent of the applied buffer bioimpedance. The SPICE model was validated via a comparison of the simulation and experimental results obtained from the already existing prototype system. The SPICE model results were in good agreement with the experimental results, and the model complexity was found to be sufficient for analysis of transient processes. As result, the proposed SPICE model can be useful for evaluation and compensation of transient processes in sub-microsecond pulsed power set-ups during the development of new prototypes. View Full-Text
Keywords: electroporation; SPICE model; pulsed electric field; high-voltage generator electroporation; SPICE model; pulsed electric field; high-voltage generator
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Butkus, P.; Tolvaišienė, S.; Kurčevskis, S. Validation of a SPICE Model for High Frequency Electroporation Systems. Electronics 2019, 8, 710.

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