Next Article in Journal
A Survey of Algorithms and Systems for Evacuating People in Confined Spaces
Previous Article in Journal
Effect of Sensors Sensitivity on Lithium-Ion Battery Modeled Parameters and State of Charge: A Comparative Study
Article Menu
Issue 6 (June) cover image

Export Article

Open AccessArticle

Validation of a SPICE Model for High Frequency Electroporation Systems

Department of Electrical Engineering, Faculty of Electronics, Vilnius Gediminas Technical University, Sauletekio al. 11, Vilnius 10221, Lithuania
Author to whom correspondence should be addressed.
Electronics 2019, 8(6), 710;
Received: 29 May 2019 / Revised: 11 June 2019 / Accepted: 20 June 2019 / Published: 23 June 2019
(This article belongs to the Section Circuit and Signal Processing)
PDF [1849 KB, uploaded 23 June 2019]


In this paper, we present an analysis and a validation of a simulation program with integrated circuit emphasis (SPICE) model for a pulse forming circuit of a high frequency electroporation system, which can deliver square-wave sub-microsecond (100–900 ns) electric field pulses. The developed SPICE model is suggested for use in evaluation of transient processes that occur due to high frequency operations in prototype systems. A controlled crowbar circuit was implemented to support a variety of biological loads and to ensure a constant electric pulse rise and fall time during electroporation to be independent of the applied buffer bioimpedance. The SPICE model was validated via a comparison of the simulation and experimental results obtained from the already existing prototype system. The SPICE model results were in good agreement with the experimental results, and the model complexity was found to be sufficient for analysis of transient processes. As result, the proposed SPICE model can be useful for evaluation and compensation of transient processes in sub-microsecond pulsed power set-ups during the development of new prototypes. View Full-Text
Keywords: electroporation; SPICE model; pulsed electric field; high-voltage generator electroporation; SPICE model; pulsed electric field; high-voltage generator

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Butkus, P.; Tolvaišienė, S.; Kurčevskis, S. Validation of a SPICE Model for High Frequency Electroporation Systems. Electronics 2019, 8, 710.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Electronics EISSN 2079-9292 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top