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Article

An Uncontrolled Case Series Using a Botanically Derived, β-Cyclodextrin Inclusion Complex in Two Androgenetic Alopecia-Affected Male Subjects †

1
ART Inc., 101 Raintree Ln, Mahwah, NJ 07430, USA
2
Bauman Medical Center, 1450 S. Dixie Hwy, Boca Raton, FL 33432, USA
*
Author to whom correspondence should be addressed.
Abbreviated Title: Nanotechnology and botanical hair growth formulations.
Cosmetics 2020, 7(3), 65; https://doi.org/10.3390/cosmetics7030065
Received: 13 July 2020 / Revised: 3 August 2020 / Accepted: 5 August 2020 / Published: 10 August 2020
(This article belongs to the Special Issue Feature Papers in Cosmetics in 2020)
Drug-based monotherapy provides limited clinical benefits in polygenic disorders, such as androgenetic alopecia. Possible benefits must be measured against non-trivial risks of negative side effects. Several well-controlled, peer-reviewed, basic science studies have demonstrated novel mechanisms of action and potential utility for natural-based phytochemicals in the treatment of androgen-mediated disorders, including androgenetic alopecia. Yet, due to phytochemical instability, volatility, and incompatibility, the bridge from in vitro potential to clinical efficacy remains largely unmet. Recent advances in nanomaterial manipulation provide enhanced platforms, such as cyclodextrins, in which these phytochemicals may be enveloped and delivered without triggering the loss of intended function. Unexpected, positive results of an uncontrolled case series for a cyclodextrin-enabled, natural-based formula containing γ linolenic acid, β-Sitosterol, epigallocatechin gallate, and genistein, administered concomitantly via oral and topical form in two androgenetic alopecia-affected, male subjects over the course of 270 days were found. At baseline, significant baldness in the vertex scalp of both subjects was observed. Subsequent 90-day time points demonstrated marked hair thickening. On treatment day 270 (conclusion), scalp hair loss was no longer evident in either patient. Particularly in the setting of a disorders, such as androgenetic alopecia, nano-complexed, botanically-based compositions may offer beneficial adjunctives or alternatives to traditional drug-based/surgical medical treatments. View Full-Text
Keywords: hair loss; advanced drug delivery; nanoparticles; natural hair loss treatment; phytochemicals; β-cyclodextrin hair loss; advanced drug delivery; nanoparticles; natural hair loss treatment; phytochemicals; β-cyclodextrin
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MDPI and ACS Style

Marcovici, G.; Bauman, A. An Uncontrolled Case Series Using a Botanically Derived, β-Cyclodextrin Inclusion Complex in Two Androgenetic Alopecia-Affected Male Subjects. Cosmetics 2020, 7, 65. https://doi.org/10.3390/cosmetics7030065

AMA Style

Marcovici G, Bauman A. An Uncontrolled Case Series Using a Botanically Derived, β-Cyclodextrin Inclusion Complex in Two Androgenetic Alopecia-Affected Male Subjects. Cosmetics. 2020; 7(3):65. https://doi.org/10.3390/cosmetics7030065

Chicago/Turabian Style

Marcovici, Geno, and Alan Bauman. 2020. "An Uncontrolled Case Series Using a Botanically Derived, β-Cyclodextrin Inclusion Complex in Two Androgenetic Alopecia-Affected Male Subjects" Cosmetics 7, no. 3: 65. https://doi.org/10.3390/cosmetics7030065

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