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Open AccessArticle

Inonotus obliquus Extracts Decreased Expression of MMP1 mRNA via JNK-AP-1 Axis

Department of Beauty & Cosmetics, Osan University, 45 Cheonghak-ro, Osan, Gyeonggi-do 18119, Korea
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Cosmetics 2020, 7(2), 36; https://doi.org/10.3390/cosmetics7020036
Received: 6 April 2020 / Revised: 6 May 2020 / Accepted: 13 May 2020 / Published: 18 May 2020
(This article belongs to the Special Issue Feature Papers in Cosmetics in 2020)
Inonotus obliquus, which is parasitic on birch and other trees, is a fungus in the family Hymenochaetaceae. In this study, we investigated whether Inonotus obliquus extracts used in traditional medicine were decreased in the expression of matrix metalloproteinases-1 (MMP-1) in the normal human dermal fibroblasts. As shown in our results, extracts of Inonotus obliquus decreased MMP1 expression in oxidative stress-exposed normal human dermal fibroblasts. Additionally, Inonotus obliquus extracts decreased AP-1 transcriptional activity and phospho-JNK in oxidative stress-exposed normal human dermal fibroblasts. Oxidative stress mediated the elevation of MMP1 mRNA expression and was well regulated by the JNK-AP-1 axis. Therefore, the results suggest that Inonotus obliquus extracts decreased MMP1 mRNA expression by regulating JNK-AP-1 axis. Additionally, Inonotus obliquus extracts have the potential to reduce collagen destruction and the formation of wrinkles and to be used as a cosmetic ingredient. View Full-Text
Keywords: Inonotus obliquus extracts; MMP1; human dermal fibroblasts; JNK; AP-1 Inonotus obliquus extracts; MMP1; human dermal fibroblasts; JNK; AP-1
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Kim, Y.J.; Cha, H.J. Inonotus obliquus Extracts Decreased Expression of MMP1 mRNA via JNK-AP-1 Axis. Cosmetics 2020, 7, 36.

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